ISCA1-WWP1 Fusion FISH Probe
The ISCA1-WWP1 Fusion FISH Probe is used to confirm a fusion of the ISCA1 and WWP1 genes. The fusion of the ISCA1 and WWP1 genes has been associated with Sarcoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| ISCA1-WWP1-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| ISCA1-WWP1-20-RERE | 20 (40 μL) | 200 μL |
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| ISCA1-WWP1-20-REOR | 20 (40 μL) | 200 μL |
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| ISCA1-WWP1-20-REGO | 20 (40 μL) | 200 μL |
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| ISCA1-WWP1-20-REGR | 20 (40 μL) | 200 μL |
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| ISCA1-WWP1-20-REAQ | 20 (40 μL) | 200 μL |
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| ISCA1-WWP1-20-ORRE | 20 (40 μL) | 200 μL |
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| ISCA1-WWP1-20-OROR | 20 (40 μL) | 200 μL |
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| ISCA1-WWP1-20-ORGO | 20 (40 μL) | 200 μL |
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| ISCA1-WWP1-20-ORAQ | 20 (40 μL) | 200 μL |
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| ISCA1-WWP1-20-GORE | 20 (40 μL) | 200 μL |
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| ISCA1-WWP1-20-GOOR | 20 (40 μL) | 200 μL |
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| ISCA1-WWP1-20-GOGO | 20 (40 μL) | 200 μL |
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| ISCA1-WWP1-20-GOGR | 20 (40 μL) | 200 μL |
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| ISCA1-WWP1-20-GOAQ | 20 (40 μL) | 200 μL |
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| ISCA1-WWP1-20-GRRE | 20 (40 μL) | 200 μL |
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| ISCA1-WWP1-20-GROR | 20 (40 μL) | 200 μL |
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| ISCA1-WWP1-20-GRGO | 20 (40 μL) | 200 μL |
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| ISCA1-WWP1-20-GRGR | 20 (40 μL) | 200 μL |
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| ISCA1-WWP1-20-GRAQ | 20 (40 μL) | 200 μL |
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| ISCA1-WWP1-20-AQRE | 20 (40 μL) | 200 μL |
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| ISCA1-WWP1-20-AQOR | 20 (40 μL) | 200 μL |
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| ISCA1-WWP1-20-AQGO | 20 (40 μL) | 200 μL |
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| ISCA1-WWP1-20-AQGR | 20 (40 μL) | 200 μL |
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| ISCA1-WWP1-20-AQAQ | 20 (40 μL) | 200 μL |
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WWP1 Gene Summary
WW domain-containing proteins are found in all eukaryotes and play an important role in the regulation of a wide variety of cellular functions such as protein degradation, transcription, and RNA splicing. This gene encodes a protein which contains 4 tandem WW domains and a HECT (homologous to the E6-associated protein carboxyl terminus) domain. The encoded protein belongs to a family of NEDD4-like proteins, which are E3 ubiquitin-ligase molecules and regulate key trafficking decisions, including targeting of proteins to proteosomes or lysosomes. Alternative splicing of this gene generates at least 6 transcript variants; however, the full length nature of these transcripts has not been defined. [provided by RefSeq, Jul 2008]
Gene Name: WW Domain Containing E3 Ubiquitin Protein Ligase 1
Chromosome: CHR8: 87354993 -87480178
Locus: 8q21.3
ISCA1 Gene Summary
ISCA1 is a mitochondrial protein involved in the biogenesis and assembly of iron-sulfur clusters, which play a role in electron-transfer reactions (Cozar-Castellano et al., 2004 [PubMed 15262227]).[supplied by OMIM, Mar 2008]
Gene Name: Iron-sulfur Cluster Assembly 1
Chromosome: CHR9: 88879462 -88897490
Locus: 9q21.33
Gene Diseases
The ISCA1 WWP1 Fusion has been associated with the following diseases:
| Disease Name |
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| Sarcoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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