IRF6-SRGAP2 Fusion FISH Probe
The IRF6-SRGAP2 Fusion FISH Probe is used to confirm a fusion of the IRF6 and SRGAP2 genes. The fusion of the IRF6 and SRGAP2 genes has been associated with Lung Squamous Cell Carcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| IRF6-SRGAP2-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| IRF6-SRGAP2-20-RERE | 20 (40 μL) | 200 μL |
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| IRF6-SRGAP2-20-REOR | 20 (40 μL) | 200 μL |
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| IRF6-SRGAP2-20-REGO | 20 (40 μL) | 200 μL |
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| IRF6-SRGAP2-20-REGR | 20 (40 μL) | 200 μL |
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| IRF6-SRGAP2-20-REAQ | 20 (40 μL) | 200 μL |
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| IRF6-SRGAP2-20-ORRE | 20 (40 μL) | 200 μL |
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| IRF6-SRGAP2-20-OROR | 20 (40 μL) | 200 μL |
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| IRF6-SRGAP2-20-ORGO | 20 (40 μL) | 200 μL |
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| IRF6-SRGAP2-20-ORAQ | 20 (40 μL) | 200 μL |
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| IRF6-SRGAP2-20-GORE | 20 (40 μL) | 200 μL |
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| IRF6-SRGAP2-20-GOOR | 20 (40 μL) | 200 μL |
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| IRF6-SRGAP2-20-GOGO | 20 (40 μL) | 200 μL |
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| IRF6-SRGAP2-20-GOGR | 20 (40 μL) | 200 μL |
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| IRF6-SRGAP2-20-GOAQ | 20 (40 μL) | 200 μL |
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| IRF6-SRGAP2-20-GRRE | 20 (40 μL) | 200 μL |
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| IRF6-SRGAP2-20-GROR | 20 (40 μL) | 200 μL |
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| IRF6-SRGAP2-20-GRGO | 20 (40 μL) | 200 μL |
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| IRF6-SRGAP2-20-GRGR | 20 (40 μL) | 200 μL |
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| IRF6-SRGAP2-20-GRAQ | 20 (40 μL) | 200 μL |
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| IRF6-SRGAP2-20-AQRE | 20 (40 μL) | 200 μL |
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| IRF6-SRGAP2-20-AQOR | 20 (40 μL) | 200 μL |
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| IRF6-SRGAP2-20-AQGO | 20 (40 μL) | 200 μL |
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| IRF6-SRGAP2-20-AQGR | 20 (40 μL) | 200 μL |
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| IRF6-SRGAP2-20-AQAQ | 20 (40 μL) | 200 μL |
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IRF6 Gene Summary
This gene encodes a member of the interferon regulatory transcription factor (IRF) family. Family members share a highly-conserved N-terminal helix-turn-helix DNA-binding domain and a less conserved C-terminal protein-binding domain. The encoded protein may be a transcriptional activator. Mutations in this gene can cause van der Woude syndrome and popliteal pterygium syndrome. Mutations in this gene are also associated with non-syndromic orofacial cleft type 6. Alternate splicing results in multiple transcript variants.[provided by RefSeq, May 2011]
Gene Name: Interferon Regulatory Factor 6
Chromosome: CHR1: 209958967 -209979520
Locus: 1q32.2
SRGAP2 Gene Summary
This locus encodes a member of the SLIT-ROBO Rho GTPase activating protein family. The encoded protein stimulates GTPase activity of Rac1, and plays a role in cortical neuron development. This locus has several paralogs on human chromosome 1 resulting from segmental duplication. While this locus itself is conserved among various species, the paralogs are found only in the genus Homo, and not in the genomes of non-human great apes. Alternatively spliced transcript variants have been described for this locus. [provided by RefSeq, Jul 2014]
Gene Name: SLIT-ROBO Rho GTPase Activating Protein 2
Chromosome: CHR1: 206516199 -206637783
Locus: 1q32.1
Gene Diseases
The IRF6 SRGAP2 Fusion has been associated with the following diseases:
| Disease Name |
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| Lung Squamous Cell Carcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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