IRF2BP2-NTRK1 Fusion FISH Probe
The IRF2BP2-NTRK1 Fusion FISH Probe is used to confirm a fusion of the IRF2BP2 and NTRK1 genes. The fusion of the IRF2BP2 and NTRK1 genes has been associated with Thyroid Carcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| IRF2BP2-NTRK1-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| IRF2BP2-NTRK1-20-RERE | 20 (40 μL) | 200 μL |
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| IRF2BP2-NTRK1-20-REOR | 20 (40 μL) | 200 μL |
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| IRF2BP2-NTRK1-20-REGO | 20 (40 μL) | 200 μL |
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| IRF2BP2-NTRK1-20-REGR | 20 (40 μL) | 200 μL |
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| IRF2BP2-NTRK1-20-REAQ | 20 (40 μL) | 200 μL |
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| IRF2BP2-NTRK1-20-ORRE | 20 (40 μL) | 200 μL |
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| IRF2BP2-NTRK1-20-OROR | 20 (40 μL) | 200 μL |
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| IRF2BP2-NTRK1-20-ORGO | 20 (40 μL) | 200 μL |
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| IRF2BP2-NTRK1-20-ORAQ | 20 (40 μL) | 200 μL |
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| IRF2BP2-NTRK1-20-GORE | 20 (40 μL) | 200 μL |
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| IRF2BP2-NTRK1-20-GOOR | 20 (40 μL) | 200 μL |
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| IRF2BP2-NTRK1-20-GOGO | 20 (40 μL) | 200 μL |
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| IRF2BP2-NTRK1-20-GOGR | 20 (40 μL) | 200 μL |
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| IRF2BP2-NTRK1-20-GOAQ | 20 (40 μL) | 200 μL |
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| IRF2BP2-NTRK1-20-GRRE | 20 (40 μL) | 200 μL |
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| IRF2BP2-NTRK1-20-GROR | 20 (40 μL) | 200 μL |
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| IRF2BP2-NTRK1-20-GRGO | 20 (40 μL) | 200 μL |
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| IRF2BP2-NTRK1-20-GRGR | 20 (40 μL) | 200 μL |
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| IRF2BP2-NTRK1-20-GRAQ | 20 (40 μL) | 200 μL |
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| IRF2BP2-NTRK1-20-AQRE | 20 (40 μL) | 200 μL |
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| IRF2BP2-NTRK1-20-AQOR | 20 (40 μL) | 200 μL |
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| IRF2BP2-NTRK1-20-AQGO | 20 (40 μL) | 200 μL |
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| IRF2BP2-NTRK1-20-AQGR | 20 (40 μL) | 200 μL |
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| IRF2BP2-NTRK1-20-AQAQ | 20 (40 μL) | 200 μL |
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NTRK1 Gene Summary
This gene encodes a member of the neurotrophic tyrosine kinase receptor (NTKR) family. This kinase is a membrane-bound receptor that, upon neurotrophin binding, phosphorylates itself and members of the MAPK pathway. The presence of this kinase leads to cell differentiation and may play a role in specifying sensory neuron subtypes. Mutations in this gene have been associated with congenital insensitivity to pain, anhidrosis, self-mutilating behavior, cognitive disability and cancer. Alternate transcriptional splice variants of this gene have been found, but only three have been characterized to date. [provided by RefSeq, Jul 2008]
Gene Name: Neurotrophic Receptor Tyrosine Kinase 1
Chromosome: CHR1: 156785541 -156851642
Locus: 1q23.1
IRF2BP2 Gene Summary
This gene encodes an interferon regulatory factor-2 (IRF2) binding protein that interacts with the C-terminal transcriptional repression domain of IRF2. Alternative splicing results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq, Jul 2008]
Gene Name: Interferon Regulatory Factor 2 Binding Protein 2
Chromosome: CHR1: 234740014 -234745271
Locus: 1q42.3
Gene Diseases
The IRF2BP2 NTRK1 Fusion has been associated with the following diseases:
| Disease Name |
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| Thyroid Carcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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