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IRF2BP2-NTRK1 Fusion FISH Probe

The IRF2BP2-NTRK1 Fusion FISH Probe is used to confirm a fusion of the IRF2BP2 and NTRK1 genes. The fusion of the IRF2BP2 and NTRK1 genes has been associated with Thyroid Carcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.

** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.

Turnaround Time: 7-10 Business Days    Shipping Time: 1-2 Day Expedited Shipping

SKU Test Kits Buffer Dye Color Order Now
IRF2BP2-NTRK1-20-ORGR  (Standard Design) 20 (40 μL) 200 μL
IRF2BP2-NTRK1-20-RERE 20 (40 μL) 200 μL
IRF2BP2-NTRK1-20-REOR 20 (40 μL) 200 μL
IRF2BP2-NTRK1-20-REGO 20 (40 μL) 200 μL
IRF2BP2-NTRK1-20-REGR 20 (40 μL) 200 μL
IRF2BP2-NTRK1-20-REAQ 20 (40 μL) 200 μL
IRF2BP2-NTRK1-20-ORRE 20 (40 μL) 200 μL
IRF2BP2-NTRK1-20-OROR 20 (40 μL) 200 μL
IRF2BP2-NTRK1-20-ORGO 20 (40 μL) 200 μL
IRF2BP2-NTRK1-20-ORAQ 20 (40 μL) 200 μL
IRF2BP2-NTRK1-20-GORE 20 (40 μL) 200 μL
IRF2BP2-NTRK1-20-GOOR 20 (40 μL) 200 μL
IRF2BP2-NTRK1-20-GOGO 20 (40 μL) 200 μL
IRF2BP2-NTRK1-20-GOGR 20 (40 μL) 200 μL
IRF2BP2-NTRK1-20-GOAQ 20 (40 μL) 200 μL
IRF2BP2-NTRK1-20-GRRE 20 (40 μL) 200 μL
IRF2BP2-NTRK1-20-GROR 20 (40 μL) 200 μL
IRF2BP2-NTRK1-20-GRGO 20 (40 μL) 200 μL
IRF2BP2-NTRK1-20-GRGR 20 (40 μL) 200 μL
IRF2BP2-NTRK1-20-GRAQ 20 (40 μL) 200 μL
IRF2BP2-NTRK1-20-AQRE 20 (40 μL) 200 μL
IRF2BP2-NTRK1-20-AQOR 20 (40 μL) 200 μL
IRF2BP2-NTRK1-20-AQGO 20 (40 μL) 200 μL
IRF2BP2-NTRK1-20-AQGR 20 (40 μL) 200 μL
IRF2BP2-NTRK1-20-AQAQ 20 (40 μL) 200 μL

NTRK1 Gene Summary

This gene encodes a member of the neurotrophic tyrosine kinase receptor (NTKR) family. This kinase is a membrane-bound receptor that, upon neurotrophin binding, phosphorylates itself and members of the MAPK pathway. The presence of this kinase leads to cell differentiation and may play a role in specifying sensory neuron subtypes. Mutations in this gene have been associated with congenital insensitivity to pain, anhidrosis, self-mutilating behavior, cognitive disability and cancer. Alternate transcriptional splice variants of this gene have been found, but only three have been characterized to date. [provided by RefSeq, Jul 2008]

Gene Name: Neurotrophic Receptor Tyrosine Kinase 1

Chromosome: CHR1: 156785541 -156851642

Locus: 1q23.1

IRF2BP2 Gene Summary

This gene encodes an interferon regulatory factor-2 (IRF2) binding protein that interacts with the C-terminal transcriptional repression domain of IRF2. Alternative splicing results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq, Jul 2008]

Gene Name: Interferon Regulatory Factor 2 Binding Protein 2

Chromosome: CHR1: 234740014 -234745271

Locus: 1q42.3

Gene Diseases

The IRF2BP2 NTRK1 Fusion has been associated with the following diseases:

Disease Name
Thyroid Carcinoma

FISH Probe Protocols

Protocol, Procedure, or Form Name Last Modified Download

TRKA expression and NTRK1 gene copy number across solid tumours

Our NTRK1 break apart probe was used to detect NTRK1 rearrangements in solid tumors from more than 1,000 patients. Over 14 different cancer types were analyzed, including lung, colorectal, and breast. NTRK1 translocations were identified in 5.9% of patients.

TRKA expression and NTRK1 gene copy number across solid tumours

Our NTRK1 break apart probe was used to detect NTRK1 rearrangements in solid tumors from more than 1,000 patients. Over 14 different cancer types were analyzed, including lung, colorectal, and breast. NTRK1 translocations were identified in 5.9% of patients.

Atypical Spitzoid Neoplasms in Childhood: A Molecular and Outcome Study

Atypical spitzoid neoplasms (APNs) are primarily pediatric lesions characterized by their intermediate features; clinically and histopathologically, they fall somewhere between benign spitz nevi and malignant melanoma. The genetics of these tumors are still poorly understood. In this study, 34 APNs were analyzed using FISH and IHC. Our ALK, BRAF, and NTRK1 break-apart FISH probes were used to detect rearrangements of the genes .

Identification and characterization of a novel SCYL3-NTRK1 rearrangement in a colorectal cancer patient

Our NTRK1 break apart probe helped to detect a new NTRK1 fusion in a 61 year old patient with adenocarcinoma of the right colon and pancreas. The team was able to verify that this novel fusion – SCYL3-NTRK1 – was in fact an oncogenic driver by transfecting cells with a SCYL3-NTRK1 cDNA construct, which lead to IL3-independent proliferation.