IREB2-LEO1 Fusion FISH Probe
The IREB2-LEO1 Fusion FISH Probe is used to confirm a fusion of the IREB2 and LEO1 genes. The fusion of the IREB2 and LEO1 genes has been associated with Prostate Adenocarcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| IREB2-LEO1-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| IREB2-LEO1-20-RERE | 20 (40 μL) | 200 μL |
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| IREB2-LEO1-20-REOR | 20 (40 μL) | 200 μL |
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| IREB2-LEO1-20-REGO | 20 (40 μL) | 200 μL |
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| IREB2-LEO1-20-REGR | 20 (40 μL) | 200 μL |
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| IREB2-LEO1-20-REAQ | 20 (40 μL) | 200 μL |
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| IREB2-LEO1-20-ORRE | 20 (40 μL) | 200 μL |
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| IREB2-LEO1-20-OROR | 20 (40 μL) | 200 μL |
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| IREB2-LEO1-20-ORGO | 20 (40 μL) | 200 μL |
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| IREB2-LEO1-20-ORAQ | 20 (40 μL) | 200 μL |
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| IREB2-LEO1-20-GORE | 20 (40 μL) | 200 μL |
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| IREB2-LEO1-20-GOOR | 20 (40 μL) | 200 μL |
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| IREB2-LEO1-20-GOGO | 20 (40 μL) | 200 μL |
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| IREB2-LEO1-20-GOGR | 20 (40 μL) | 200 μL |
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| IREB2-LEO1-20-GOAQ | 20 (40 μL) | 200 μL |
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| IREB2-LEO1-20-GRRE | 20 (40 μL) | 200 μL |
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| IREB2-LEO1-20-GROR | 20 (40 μL) | 200 μL |
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| IREB2-LEO1-20-GRGO | 20 (40 μL) | 200 μL |
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| IREB2-LEO1-20-GRGR | 20 (40 μL) | 200 μL |
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| IREB2-LEO1-20-GRAQ | 20 (40 μL) | 200 μL |
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| IREB2-LEO1-20-AQRE | 20 (40 μL) | 200 μL |
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| IREB2-LEO1-20-AQOR | 20 (40 μL) | 200 μL |
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| IREB2-LEO1-20-AQGO | 20 (40 μL) | 200 μL |
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| IREB2-LEO1-20-AQGR | 20 (40 μL) | 200 μL |
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| IREB2-LEO1-20-AQAQ | 20 (40 μL) | 200 μL |
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IREB2 Gene Summary
The protein encoded by this gene is an RNA-binding protein that acts to regulate iron levels in the cells by regulating the translation and stability of mRNAs that affect iron homeostasis under conditions when iron is depleted. When iron levels are low, this protein binds to iron-responsive elements (IRES), stem-loop structures located either in the 5' or 3' UTRs. Binding to the 5' UTR represses translation, while binding to the 3' UTR inhibits mRNA degradation. When iron is found in the cell, this protein is degraded in a F-box and leucine rich repeat protein 5-dependent manner. Variants in this gene have been associated with lung cancer and chronic obstructive pulmonary disease (COPD). Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Aug 2017]
Gene Name: Iron Responsive Element Binding Protein 2
Chromosome: CHR15: 78730517 -78793798
Locus: 15q25.1
LEO1 Gene Summary
LEO1, parafibromin (CDC73; MIM 607393), CTR9 (MIM 609366), and PAF1 (MIM 610506) form the PAF protein complex that associates with the RNA polymerase II subunit POLR2A (MIM 180660) and with a histone methyltransferase complex (Rozenblatt-Rosen et al., 2005 [PubMed 15632063]).[supplied by OMIM, Mar 2008]
Gene Name: LEO1 Homolog, Paf1/RNA Polymerase II Complex Component
Chromosome: CHR15: 52230221 -52263958
Locus: 15q21.2
Gene Diseases
The IREB2 LEO1 Fusion has been associated with the following diseases:
| Disease Name |
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| Prostate Adenocarcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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