IREB2-DIAPH3 Fusion FISH Probe
The IREB2-DIAPH3 Fusion FISH Probe is used to confirm a fusion of the IREB2 and DIAPH3 genes. The fusion of the IREB2 and DIAPH3 genes has been associated with Skin Cutaneous Melanoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| IREB2-DIAPH3-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| IREB2-DIAPH3-20-RERE | 20 (40 μL) | 200 μL |
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| IREB2-DIAPH3-20-REOR | 20 (40 μL) | 200 μL |
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| IREB2-DIAPH3-20-REGO | 20 (40 μL) | 200 μL |
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| IREB2-DIAPH3-20-REGR | 20 (40 μL) | 200 μL |
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| IREB2-DIAPH3-20-REAQ | 20 (40 μL) | 200 μL |
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| IREB2-DIAPH3-20-ORRE | 20 (40 μL) | 200 μL |
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| IREB2-DIAPH3-20-OROR | 20 (40 μL) | 200 μL |
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| IREB2-DIAPH3-20-ORGO | 20 (40 μL) | 200 μL |
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| IREB2-DIAPH3-20-ORAQ | 20 (40 μL) | 200 μL |
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| IREB2-DIAPH3-20-GORE | 20 (40 μL) | 200 μL |
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| IREB2-DIAPH3-20-GOOR | 20 (40 μL) | 200 μL |
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| IREB2-DIAPH3-20-GOGO | 20 (40 μL) | 200 μL |
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| IREB2-DIAPH3-20-GOGR | 20 (40 μL) | 200 μL |
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| IREB2-DIAPH3-20-GOAQ | 20 (40 μL) | 200 μL |
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| IREB2-DIAPH3-20-GRRE | 20 (40 μL) | 200 μL |
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| IREB2-DIAPH3-20-GROR | 20 (40 μL) | 200 μL |
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| IREB2-DIAPH3-20-GRGO | 20 (40 μL) | 200 μL |
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| IREB2-DIAPH3-20-GRGR | 20 (40 μL) | 200 μL |
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| IREB2-DIAPH3-20-GRAQ | 20 (40 μL) | 200 μL |
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| IREB2-DIAPH3-20-AQRE | 20 (40 μL) | 200 μL |
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| IREB2-DIAPH3-20-AQOR | 20 (40 μL) | 200 μL |
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| IREB2-DIAPH3-20-AQGO | 20 (40 μL) | 200 μL |
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| IREB2-DIAPH3-20-AQGR | 20 (40 μL) | 200 μL |
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| IREB2-DIAPH3-20-AQAQ | 20 (40 μL) | 200 μL |
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IREB2 Gene Summary
The protein encoded by this gene is an RNA-binding protein that acts to regulate iron levels in the cells by regulating the translation and stability of mRNAs that affect iron homeostasis under conditions when iron is depleted. When iron levels are low, this protein binds to iron-responsive elements (IRES), stem-loop structures located either in the 5' or 3' UTRs. Binding to the 5' UTR represses translation, while binding to the 3' UTR inhibits mRNA degradation. When iron is found in the cell, this protein is degraded in a F-box and leucine rich repeat protein 5-dependent manner. Variants in this gene have been associated with lung cancer and chronic obstructive pulmonary disease (COPD). Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Aug 2017]
Gene Name: Iron Responsive Element Binding Protein 2
Chromosome: CHR15: 78730517 -78793798
Locus: 15q25.1
DIAPH3 Gene Summary
This gene encodes a member of the diaphanous subfamily of the formin family. Members of this family are involved in actin remodeling and regulate cell movement and adhesion. Mutations in this gene are associated with autosomal dominant auditory neuropathy 1. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Apr 2012]
Gene Name: Diaphanous Related Formin 3
Chromosome: CHR13: 60239722 -60738119
Locus: 13q21.2
Gene Diseases
The IREB2 DIAPH3 Fusion has been associated with the following diseases:
| Disease Name |
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| Skin Cutaneous Melanoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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