IRAK3-DYRK2 Fusion FISH Probe
The IRAK3-DYRK2 Fusion FISH Probe is used to confirm a fusion of the IRAK3 and DYRK2 genes. The fusion of the IRAK3 and DYRK2 genes has been associated with Sarcoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| IRAK3-DYRK2-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| IRAK3-DYRK2-20-RERE | 20 (40 μL) | 200 μL |
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| IRAK3-DYRK2-20-REOR | 20 (40 μL) | 200 μL |
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| IRAK3-DYRK2-20-REGO | 20 (40 μL) | 200 μL |
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| IRAK3-DYRK2-20-REGR | 20 (40 μL) | 200 μL |
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| IRAK3-DYRK2-20-REAQ | 20 (40 μL) | 200 μL |
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| IRAK3-DYRK2-20-ORRE | 20 (40 μL) | 200 μL |
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| IRAK3-DYRK2-20-OROR | 20 (40 μL) | 200 μL |
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| IRAK3-DYRK2-20-ORGO | 20 (40 μL) | 200 μL |
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| IRAK3-DYRK2-20-ORAQ | 20 (40 μL) | 200 μL |
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| IRAK3-DYRK2-20-GORE | 20 (40 μL) | 200 μL |
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| IRAK3-DYRK2-20-GOOR | 20 (40 μL) | 200 μL |
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| IRAK3-DYRK2-20-GOGO | 20 (40 μL) | 200 μL |
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| IRAK3-DYRK2-20-GOGR | 20 (40 μL) | 200 μL |
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| IRAK3-DYRK2-20-GOAQ | 20 (40 μL) | 200 μL |
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| IRAK3-DYRK2-20-GRRE | 20 (40 μL) | 200 μL |
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| IRAK3-DYRK2-20-GROR | 20 (40 μL) | 200 μL |
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| IRAK3-DYRK2-20-GRGO | 20 (40 μL) | 200 μL |
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| IRAK3-DYRK2-20-GRGR | 20 (40 μL) | 200 μL |
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| IRAK3-DYRK2-20-GRAQ | 20 (40 μL) | 200 μL |
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| IRAK3-DYRK2-20-AQRE | 20 (40 μL) | 200 μL |
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| IRAK3-DYRK2-20-AQOR | 20 (40 μL) | 200 μL |
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| IRAK3-DYRK2-20-AQGO | 20 (40 μL) | 200 μL |
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| IRAK3-DYRK2-20-AQGR | 20 (40 μL) | 200 μL |
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| IRAK3-DYRK2-20-AQAQ | 20 (40 μL) | 200 μL |
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DYRK2 Gene Summary
DYRK2 belongs to a family of protein kinases whose members are presumed to be involved in cellular growth and/or development. The family is defined by structural similarity of their kinase domains and their capability to autophosphorylate on tyrosine residues. DYRK2 has demonstrated tyrosine autophosphorylation and catalyzed phosphorylation of histones H3 and H2B in vitro. Two isoforms of DYRK2 have been isolated. The predominant isoform, isoform 1, lacks a 5' terminal insert. [provided by RefSeq, Jul 2008]
Gene Name: Dual Specificity Tyrosine Phosphorylation Regulated Kinase 2
Chromosome: CHR12: 68042511 -68056444
Locus: 12q15
IRAK3 Gene Summary
This gene encodes a member of the interleukin-1 receptor-associated kinase protein family. Members of this family are essential components of the Toll/IL-R immune signal transduction pathways. This protein is primarily expressed in monocytes and macrophages and functions as a negative regulator of Toll-like receptor signaling. Mutations in this gene are associated with a susceptibility to asthma. Alternate splicing results in multiple transcript variants. [provided by RefSeq, May 2010]
Gene Name: Interleukin 1 Receptor Associated Kinase 3
Chromosome: CHR12: 66582977 -66648394
Locus: 12q14.3
Gene Diseases
The IRAK3 DYRK2 Fusion has been associated with the following diseases:
| Disease Name |
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| Sarcoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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