IQGAP1-SEMA4B Fusion FISH Probe
The IQGAP1-SEMA4B Fusion FISH Probe is used to confirm a fusion of the IQGAP1 and SEMA4B genes. The fusion of the IQGAP1 and SEMA4B genes has been associated with Uterine Corpus Endometrial Carcinoma, Colon Adenocarcinoma, Stomach Adenocarcinoma, Stomach Adenocarcinoma, and Pancreatic Adenocarcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| IQGAP1-SEMA4B-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| IQGAP1-SEMA4B-20-RERE | 20 (40 μL) | 200 μL |
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| IQGAP1-SEMA4B-20-REOR | 20 (40 μL) | 200 μL |
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| IQGAP1-SEMA4B-20-REGO | 20 (40 μL) | 200 μL |
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| IQGAP1-SEMA4B-20-REGR | 20 (40 μL) | 200 μL |
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| IQGAP1-SEMA4B-20-REAQ | 20 (40 μL) | 200 μL |
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| IQGAP1-SEMA4B-20-ORRE | 20 (40 μL) | 200 μL |
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| IQGAP1-SEMA4B-20-OROR | 20 (40 μL) | 200 μL |
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| IQGAP1-SEMA4B-20-ORGO | 20 (40 μL) | 200 μL |
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| IQGAP1-SEMA4B-20-ORAQ | 20 (40 μL) | 200 μL |
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| IQGAP1-SEMA4B-20-GORE | 20 (40 μL) | 200 μL |
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| IQGAP1-SEMA4B-20-GOOR | 20 (40 μL) | 200 μL |
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| IQGAP1-SEMA4B-20-GOGO | 20 (40 μL) | 200 μL |
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| IQGAP1-SEMA4B-20-GOGR | 20 (40 μL) | 200 μL |
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| IQGAP1-SEMA4B-20-GOAQ | 20 (40 μL) | 200 μL |
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| IQGAP1-SEMA4B-20-GRRE | 20 (40 μL) | 200 μL |
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| IQGAP1-SEMA4B-20-GROR | 20 (40 μL) | 200 μL |
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| IQGAP1-SEMA4B-20-GRGO | 20 (40 μL) | 200 μL |
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| IQGAP1-SEMA4B-20-GRGR | 20 (40 μL) | 200 μL |
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| IQGAP1-SEMA4B-20-GRAQ | 20 (40 μL) | 200 μL |
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| IQGAP1-SEMA4B-20-AQRE | 20 (40 μL) | 200 μL |
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| IQGAP1-SEMA4B-20-AQOR | 20 (40 μL) | 200 μL |
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| IQGAP1-SEMA4B-20-AQGO | 20 (40 μL) | 200 μL |
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| IQGAP1-SEMA4B-20-AQGR | 20 (40 μL) | 200 μL |
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| IQGAP1-SEMA4B-20-AQAQ | 20 (40 μL) | 200 μL |
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IQGAP1 Gene Summary
This gene encodes a member of the IQGAP family. The protein contains four IQ domains, one calponin homology domain, one Ras-GAP domain and one WW domain. It interacts with components of the cytoskeleton, with cell adhesion molecules, and with several signaling molecules to regulate cell morphology and motility. Expression of the protein is upregulated by gene amplification in two gastric cancer cell lines. [provided by RefSeq, Jul 2008]
Gene Name: IQ Motif Containing GTPase Activating Protein 1
Chromosome: CHR15: 90931472 -91045475
Locus: 15q26.1
SEMA4B Gene Summary
The Semaphorin 4B (SEMA4B) gene is located on chr15 :90728151-90772892 at 15q26.1.
Gene Name: Semaphorin 4B
Chromosome: CHR15: 90728151 -90772892
Locus: 15q26.1
Gene Diseases
The IQGAP1 SEMA4B Fusion has been associated with the following diseases:
| Disease Name |
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| Uterine Corpus Endometrial Carcinoma |
| Colon Adenocarcinoma |
| Stomach Adenocarcinoma |
| Stomach Adenocarcinoma |
| Pancreatic Adenocarcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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