IQGAP1-MESP2 Fusion FISH Probe
The IQGAP1-MESP2 Fusion FISH Probe is used to confirm a fusion of the IQGAP1 and MESP2 genes. The fusion of the IQGAP1 and MESP2 genes has been associated with Breast Invasive Carcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| IQGAP1-MESP2-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| IQGAP1-MESP2-20-RERE | 20 (40 μL) | 200 μL |
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| IQGAP1-MESP2-20-REOR | 20 (40 μL) | 200 μL |
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| IQGAP1-MESP2-20-REGO | 20 (40 μL) | 200 μL |
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| IQGAP1-MESP2-20-REGR | 20 (40 μL) | 200 μL |
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| IQGAP1-MESP2-20-REAQ | 20 (40 μL) | 200 μL |
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| IQGAP1-MESP2-20-ORRE | 20 (40 μL) | 200 μL |
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| IQGAP1-MESP2-20-OROR | 20 (40 μL) | 200 μL |
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| IQGAP1-MESP2-20-ORGO | 20 (40 μL) | 200 μL |
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| IQGAP1-MESP2-20-ORAQ | 20 (40 μL) | 200 μL |
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| IQGAP1-MESP2-20-GORE | 20 (40 μL) | 200 μL |
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| IQGAP1-MESP2-20-GOOR | 20 (40 μL) | 200 μL |
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| IQGAP1-MESP2-20-GOGO | 20 (40 μL) | 200 μL |
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| IQGAP1-MESP2-20-GOGR | 20 (40 μL) | 200 μL |
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| IQGAP1-MESP2-20-GOAQ | 20 (40 μL) | 200 μL |
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| IQGAP1-MESP2-20-GRRE | 20 (40 μL) | 200 μL |
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| IQGAP1-MESP2-20-GROR | 20 (40 μL) | 200 μL |
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| IQGAP1-MESP2-20-GRGO | 20 (40 μL) | 200 μL |
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| IQGAP1-MESP2-20-GRGR | 20 (40 μL) | 200 μL |
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| IQGAP1-MESP2-20-GRAQ | 20 (40 μL) | 200 μL |
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| IQGAP1-MESP2-20-AQRE | 20 (40 μL) | 200 μL |
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| IQGAP1-MESP2-20-AQOR | 20 (40 μL) | 200 μL |
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| IQGAP1-MESP2-20-AQGO | 20 (40 μL) | 200 μL |
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| IQGAP1-MESP2-20-AQGR | 20 (40 μL) | 200 μL |
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| IQGAP1-MESP2-20-AQAQ | 20 (40 μL) | 200 μL |
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IQGAP1 Gene Summary
This gene encodes a member of the IQGAP family. The protein contains four IQ domains, one calponin homology domain, one Ras-GAP domain and one WW domain. It interacts with components of the cytoskeleton, with cell adhesion molecules, and with several signaling molecules to regulate cell morphology and motility. Expression of the protein is upregulated by gene amplification in two gastric cancer cell lines. [provided by RefSeq, Jul 2008]
Gene Name: IQ Motif Containing GTPase Activating Protein 1
Chromosome: CHR15: 90931472 -91045475
Locus: 15q26.1
MESP2 Gene Summary
This gene encodes a member of the bHLH family of transcription factors and plays a key role in defining the rostrocaudal patterning of somites via interactions with multiple Notch signaling pathways. This gene is expressed in the anterior presomitic mesoderm and is downregulated immediately after the formation of segmented somites. This gene also plays a role in the formation of epithelial somitic mesoderm and cardiac mesoderm. Mutations in the MESP2 gene cause autosomal recessive spondylocostal dystosis 2 (SCD02). [provided by RefSeq, Oct 2008]
Gene Name: Mesoderm Posterior BHLH Transcription Factor 2
Chromosome: CHR15: 90319588 -90321982
Locus: 15q26.1
Gene Diseases
The IQGAP1 MESP2 Fusion has been associated with the following diseases:
| Disease Name |
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| Breast Invasive Carcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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