IPO7-TMEM41B Fusion FISH Probe
The IPO7-TMEM41B Fusion FISH Probe is used to confirm a fusion of the IPO7 and TMEM41B genes. The fusion of the IPO7 and TMEM41B genes has been associated with Lung Adenocarcinoma, and Skin Cutaneous Melanoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| IPO7-TMEM41B-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| IPO7-TMEM41B-20-RERE | 20 (40 μL) | 200 μL |
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| IPO7-TMEM41B-20-REOR | 20 (40 μL) | 200 μL |
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| IPO7-TMEM41B-20-REGO | 20 (40 μL) | 200 μL |
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| IPO7-TMEM41B-20-REGR | 20 (40 μL) | 200 μL |
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| IPO7-TMEM41B-20-REAQ | 20 (40 μL) | 200 μL |
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| IPO7-TMEM41B-20-ORRE | 20 (40 μL) | 200 μL |
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| IPO7-TMEM41B-20-OROR | 20 (40 μL) | 200 μL |
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| IPO7-TMEM41B-20-ORGO | 20 (40 μL) | 200 μL |
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| IPO7-TMEM41B-20-ORAQ | 20 (40 μL) | 200 μL |
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| IPO7-TMEM41B-20-GORE | 20 (40 μL) | 200 μL |
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| IPO7-TMEM41B-20-GOOR | 20 (40 μL) | 200 μL |
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| IPO7-TMEM41B-20-GOGO | 20 (40 μL) | 200 μL |
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| IPO7-TMEM41B-20-GOGR | 20 (40 μL) | 200 μL |
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| IPO7-TMEM41B-20-GOAQ | 20 (40 μL) | 200 μL |
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| IPO7-TMEM41B-20-GRRE | 20 (40 μL) | 200 μL |
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| IPO7-TMEM41B-20-GROR | 20 (40 μL) | 200 μL |
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| IPO7-TMEM41B-20-GRGO | 20 (40 μL) | 200 μL |
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| IPO7-TMEM41B-20-GRGR | 20 (40 μL) | 200 μL |
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| IPO7-TMEM41B-20-GRAQ | 20 (40 μL) | 200 μL |
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| IPO7-TMEM41B-20-AQRE | 20 (40 μL) | 200 μL |
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| IPO7-TMEM41B-20-AQOR | 20 (40 μL) | 200 μL |
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| IPO7-TMEM41B-20-AQGO | 20 (40 μL) | 200 μL |
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| IPO7-TMEM41B-20-AQGR | 20 (40 μL) | 200 μL |
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| IPO7-TMEM41B-20-AQAQ | 20 (40 μL) | 200 μL |
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IPO7 Gene Summary
The importin-alpha/beta complex and the GTPase Ran mediate nuclear import of proteins with a classical nuclear localization signal. The protein encoded by this gene is a member of a class of approximately 20 potential Ran targets that share a sequence motif related to the Ran-binding site of importin-beta. Similar to importin-beta, this protein prevents the activation of Ran's GTPase by RanGAP1 and inhibits nucleotide exchange on RanGTP, and also binds directly to nuclear pore complexes where it competes for binding sites with importin-beta and transportin. This protein has a Ran-dependent transport cycle and it can cross the nuclear envelope rapidly and in both directions. At least four importin beta-like transport receptors, namely importin beta itself, transportin, RanBP5 and RanBP7, directly bind and import ribosomal proteins. [provided by RefSeq, Jul 2008]
Gene Name: Importin 7
Chromosome: CHR11: 9406168 -9469674
Locus: 11p15.4
TMEM41B Gene Summary
The Transmembrane Protein 41B (TMEM41B) gene is located on chr11 :9302200-9336315 at 11p15.4.
Gene Name: Transmembrane Protein 41B
Chromosome: CHR11: 9302200 -9336315
Locus: 11p15.4
Gene Diseases
The IPO7 TMEM41B Fusion has been associated with the following diseases:
| Disease Name |
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| Lung Adenocarcinoma |
| Skin Cutaneous Melanoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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