IPO11-CENPJ Fusion FISH Probe
The IPO11-CENPJ Fusion FISH Probe is used to confirm a fusion of the IPO11 and CENPJ genes. The fusion of the IPO11 and CENPJ genes has been associated with Breast Invasive Carcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| IPO11-CENPJ-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| IPO11-CENPJ-20-RERE | 20 (40 μL) | 200 μL |
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| IPO11-CENPJ-20-REOR | 20 (40 μL) | 200 μL |
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| IPO11-CENPJ-20-REGO | 20 (40 μL) | 200 μL |
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| IPO11-CENPJ-20-REGR | 20 (40 μL) | 200 μL |
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| IPO11-CENPJ-20-REAQ | 20 (40 μL) | 200 μL |
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| IPO11-CENPJ-20-ORRE | 20 (40 μL) | 200 μL |
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| IPO11-CENPJ-20-OROR | 20 (40 μL) | 200 μL |
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| IPO11-CENPJ-20-ORGO | 20 (40 μL) | 200 μL |
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| IPO11-CENPJ-20-ORAQ | 20 (40 μL) | 200 μL |
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| IPO11-CENPJ-20-GORE | 20 (40 μL) | 200 μL |
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| IPO11-CENPJ-20-GOOR | 20 (40 μL) | 200 μL |
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| IPO11-CENPJ-20-GOGO | 20 (40 μL) | 200 μL |
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| IPO11-CENPJ-20-GOGR | 20 (40 μL) | 200 μL |
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| IPO11-CENPJ-20-GOAQ | 20 (40 μL) | 200 μL |
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| IPO11-CENPJ-20-GRRE | 20 (40 μL) | 200 μL |
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| IPO11-CENPJ-20-GROR | 20 (40 μL) | 200 μL |
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| IPO11-CENPJ-20-GRGO | 20 (40 μL) | 200 μL |
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| IPO11-CENPJ-20-GRGR | 20 (40 μL) | 200 μL |
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| IPO11-CENPJ-20-GRAQ | 20 (40 μL) | 200 μL |
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| IPO11-CENPJ-20-AQRE | 20 (40 μL) | 200 μL |
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| IPO11-CENPJ-20-AQOR | 20 (40 μL) | 200 μL |
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| IPO11-CENPJ-20-AQGO | 20 (40 μL) | 200 μL |
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| IPO11-CENPJ-20-AQGR | 20 (40 μL) | 200 μL |
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| IPO11-CENPJ-20-AQAQ | 20 (40 μL) | 200 μL |
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IPO11 Gene Summary
Importins, including IPO11, are a members of the karyopherin/importin-beta family of transport receptors (see KPNB1; 602738) that mediate nucleocytoplasmic transport of protein and RNA cargoes (Plafker and Macara, 2000 [PubMed 11032817]).[supplied by OMIM, Sep 2008]
Gene Name: Importin 11
Chromosome: CHR5: 61708572 -61924416
Locus: 5q12.1
CENPJ Gene Summary
This gene encodes a protein that belongs to the centromere protein family. During cell division, this protein plays a structural role in the maintenance of centrosome integrity and normal spindle morphology, and it is involved in microtubule disassembly at the centrosome. This protein can function as a transcriptional coactivator in the Stat5 signaling pathway, and also as a coactivator of NF-kappaB-mediated transcription, likely via its interaction with the coactivator p300/CREB-binding protein. Mutations in this gene are associated with primary autosomal recessive microcephaly, a disorder characterized by severely reduced brain size and cognitive disability. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Apr 2012]
Gene Name: Centromere Protein J
Chromosome: CHR13: 25456411 -25497085
Locus: 13q12.12-q12.13
Gene Diseases
The IPO11 CENPJ Fusion has been associated with the following diseases:
| Disease Name |
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| Breast Invasive Carcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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