INTS4-PPFIA1 Fusion FISH Probe
The INTS4-PPFIA1 Fusion FISH Probe is used to confirm a fusion of the INTS4 and PPFIA1 genes. The fusion of the INTS4 and PPFIA1 genes has been associated with Breast Invasive Carcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| INTS4-PPFIA1-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| INTS4-PPFIA1-20-RERE | 20 (40 μL) | 200 μL |
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| INTS4-PPFIA1-20-REOR | 20 (40 μL) | 200 μL |
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| INTS4-PPFIA1-20-REGO | 20 (40 μL) | 200 μL |
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| INTS4-PPFIA1-20-REGR | 20 (40 μL) | 200 μL |
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| INTS4-PPFIA1-20-REAQ | 20 (40 μL) | 200 μL |
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| INTS4-PPFIA1-20-ORRE | 20 (40 μL) | 200 μL |
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| INTS4-PPFIA1-20-OROR | 20 (40 μL) | 200 μL |
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| INTS4-PPFIA1-20-ORGO | 20 (40 μL) | 200 μL |
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| INTS4-PPFIA1-20-ORAQ | 20 (40 μL) | 200 μL |
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| INTS4-PPFIA1-20-GORE | 20 (40 μL) | 200 μL |
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| INTS4-PPFIA1-20-GOOR | 20 (40 μL) | 200 μL |
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| INTS4-PPFIA1-20-GOGO | 20 (40 μL) | 200 μL |
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| INTS4-PPFIA1-20-GOGR | 20 (40 μL) | 200 μL |
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| INTS4-PPFIA1-20-GOAQ | 20 (40 μL) | 200 μL |
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| INTS4-PPFIA1-20-GRRE | 20 (40 μL) | 200 μL |
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| INTS4-PPFIA1-20-GROR | 20 (40 μL) | 200 μL |
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| INTS4-PPFIA1-20-GRGO | 20 (40 μL) | 200 μL |
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| INTS4-PPFIA1-20-GRGR | 20 (40 μL) | 200 μL |
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| INTS4-PPFIA1-20-GRAQ | 20 (40 μL) | 200 μL |
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| INTS4-PPFIA1-20-AQRE | 20 (40 μL) | 200 μL |
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| INTS4-PPFIA1-20-AQOR | 20 (40 μL) | 200 μL |
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| INTS4-PPFIA1-20-AQGO | 20 (40 μL) | 200 μL |
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| INTS4-PPFIA1-20-AQGR | 20 (40 μL) | 200 μL |
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| INTS4-PPFIA1-20-AQAQ | 20 (40 μL) | 200 μL |
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PPFIA1 Gene Summary
The protein encoded by this gene is a member of the LAR protein-tyrosine phosphatase-interacting protein (liprin) family. Liprins interact with members of LAR family of transmembrane protein tyrosine phosphatases, which are known to be important for axon guidance and mammary gland development. This protein binds to the intracellular membrane-distal phosphatase domain of tyrosine phosphatase LAR, and appears to localize LAR to cell focal adhesions. This interaction may regulate the disassembly of focal adhesion and thus help orchestrate cell-matrix interactions. Alternatively spliced transcript variants encoding distinct isoforms have been described. [provided by RefSeq, Jul 2008]
Gene Name: PTPRF Interacting Protein Alpha 1
Chromosome: CHR11: 70116822 -70230502
Locus: 11q13.3
INTS4 Gene Summary
INTS4 is a subunit of the Integrator complex, which associates with the C-terminal domain of RNA polymerase II large subunit (POLR2A; MIM 180660) and mediates 3-prime end processing of small nuclear RNAs U1 (RNU1; MIM 180680) and U2 (RNU2; MIM 180690) (Baillat et al., 2005 [PubMed 16239144]).[supplied by OMIM, Mar 2008]
Gene Name: Integrator Complex Subunit 4
Chromosome: CHR11: 77589765 -77705717
Locus: 11q14.1
Gene Diseases
The INTS4 PPFIA1 Fusion has been associated with the following diseases:
| Disease Name |
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| Breast Invasive Carcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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