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INTS4-PPFIA1 Fusion FISH Probe

The INTS4-PPFIA1 Fusion FISH Probe is used to confirm a fusion of the INTS4 and PPFIA1 genes. The fusion of the INTS4 and PPFIA1 genes has been associated with Breast Invasive Carcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.

** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.

Turnaround Time: 7-10 Business Days    Shipping Time: 1-2 Day Expedited Shipping

SKU Test Kits Buffer Dye Color Order Now
INTS4-PPFIA1-20-ORGR  (Standard Design) 20 (40 μL) 200 μL
INTS4-PPFIA1-20-RERE 20 (40 μL) 200 μL
INTS4-PPFIA1-20-REOR 20 (40 μL) 200 μL
INTS4-PPFIA1-20-REGO 20 (40 μL) 200 μL
INTS4-PPFIA1-20-REGR 20 (40 μL) 200 μL
INTS4-PPFIA1-20-REAQ 20 (40 μL) 200 μL
INTS4-PPFIA1-20-ORRE 20 (40 μL) 200 μL
INTS4-PPFIA1-20-OROR 20 (40 μL) 200 μL
INTS4-PPFIA1-20-ORGO 20 (40 μL) 200 μL
INTS4-PPFIA1-20-ORAQ 20 (40 μL) 200 μL
INTS4-PPFIA1-20-GORE 20 (40 μL) 200 μL
INTS4-PPFIA1-20-GOOR 20 (40 μL) 200 μL
INTS4-PPFIA1-20-GOGO 20 (40 μL) 200 μL
INTS4-PPFIA1-20-GOGR 20 (40 μL) 200 μL
INTS4-PPFIA1-20-GOAQ 20 (40 μL) 200 μL
INTS4-PPFIA1-20-GRRE 20 (40 μL) 200 μL
INTS4-PPFIA1-20-GROR 20 (40 μL) 200 μL
INTS4-PPFIA1-20-GRGO 20 (40 μL) 200 μL
INTS4-PPFIA1-20-GRGR 20 (40 μL) 200 μL
INTS4-PPFIA1-20-GRAQ 20 (40 μL) 200 μL
INTS4-PPFIA1-20-AQRE 20 (40 μL) 200 μL
INTS4-PPFIA1-20-AQOR 20 (40 μL) 200 μL
INTS4-PPFIA1-20-AQGO 20 (40 μL) 200 μL
INTS4-PPFIA1-20-AQGR 20 (40 μL) 200 μL
INTS4-PPFIA1-20-AQAQ 20 (40 μL) 200 μL

PPFIA1 Gene Summary

The protein encoded by this gene is a member of the LAR protein-tyrosine phosphatase-interacting protein (liprin) family. Liprins interact with members of LAR family of transmembrane protein tyrosine phosphatases, which are known to be important for axon guidance and mammary gland development. This protein binds to the intracellular membrane-distal phosphatase domain of tyrosine phosphatase LAR, and appears to localize LAR to cell focal adhesions. This interaction may regulate the disassembly of focal adhesion and thus help orchestrate cell-matrix interactions. Alternatively spliced transcript variants encoding distinct isoforms have been described. [provided by RefSeq, Jul 2008]

Gene Name: PTPRF Interacting Protein Alpha 1

Chromosome: CHR11: 70116822 -70230502

Locus: 11q13.3

INTS4 Gene Summary

INTS4 is a subunit of the Integrator complex, which associates with the C-terminal domain of RNA polymerase II large subunit (POLR2A; MIM 180660) and mediates 3-prime end processing of small nuclear RNAs U1 (RNU1; MIM 180680) and U2 (RNU2; MIM 180690) (Baillat et al., 2005 [PubMed 16239144]).[supplied by OMIM, Mar 2008]

Gene Name: Integrator Complex Subunit 4

Chromosome: CHR11: 77589765 -77705717

Locus: 11q14.1

Gene Diseases

The INTS4 PPFIA1 Fusion has been associated with the following diseases:

Disease Name
Breast Invasive Carcinoma

FISH Probe Protocols

Protocol, Procedure, or Form Name Last Modified Download

Customer Publications

There are currently no FISH related publications for this probe.