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INTS4-POLD3 Fusion FISH Probe

The INTS4-POLD3 Fusion FISH Probe is used to confirm a fusion of the INTS4 and POLD3 genes. The fusion of the INTS4 and POLD3 genes has been associated with Breast Invasive Carcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.

** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.

Turnaround Time: 7-10 Business Days    Shipping Time: 1-2 Day Expedited Shipping

SKU Test Kits Buffer Dye Color Order Now
INTS4-POLD3-20-ORGR  (Standard Design) 20 (40 μL) 200 μL
INTS4-POLD3-20-RERE 20 (40 μL) 200 μL
INTS4-POLD3-20-REOR 20 (40 μL) 200 μL
INTS4-POLD3-20-REGO 20 (40 μL) 200 μL
INTS4-POLD3-20-REGR 20 (40 μL) 200 μL
INTS4-POLD3-20-REAQ 20 (40 μL) 200 μL
INTS4-POLD3-20-ORRE 20 (40 μL) 200 μL
INTS4-POLD3-20-OROR 20 (40 μL) 200 μL
INTS4-POLD3-20-ORGO 20 (40 μL) 200 μL
INTS4-POLD3-20-ORAQ 20 (40 μL) 200 μL
INTS4-POLD3-20-GORE 20 (40 μL) 200 μL
INTS4-POLD3-20-GOOR 20 (40 μL) 200 μL
INTS4-POLD3-20-GOGO 20 (40 μL) 200 μL
INTS4-POLD3-20-GOGR 20 (40 μL) 200 μL
INTS4-POLD3-20-GOAQ 20 (40 μL) 200 μL
INTS4-POLD3-20-GRRE 20 (40 μL) 200 μL
INTS4-POLD3-20-GROR 20 (40 μL) 200 μL
INTS4-POLD3-20-GRGO 20 (40 μL) 200 μL
INTS4-POLD3-20-GRGR 20 (40 μL) 200 μL
INTS4-POLD3-20-GRAQ 20 (40 μL) 200 μL
INTS4-POLD3-20-AQRE 20 (40 μL) 200 μL
INTS4-POLD3-20-AQOR 20 (40 μL) 200 μL
INTS4-POLD3-20-AQGO 20 (40 μL) 200 μL
INTS4-POLD3-20-AQGR 20 (40 μL) 200 μL
INTS4-POLD3-20-AQAQ 20 (40 μL) 200 μL

POLD3 Gene Summary

This gene encodes the 66-kDa subunit of DNA polymerase delta. DNA polymerase delta possesses both polymerase and 3' to 5' exonuclease activity and plays a critical role in DNA replication and repair. The encoded protein plays a role in regulating the activity of DNA polymerase delta through interactions with other subunits and the processivity cofactor proliferating cell nuclear antigen (PCNA). Alternatively spliced transcript variants have been observed for this gene. [provided by RefSeq, Mar 2012]

Gene Name: DNA Polymerase Delta 3, Accessory Subunit

Chromosome: CHR11: 74303628 -74353765

Locus: 11q13.4

INTS4 Gene Summary

INTS4 is a subunit of the Integrator complex, which associates with the C-terminal domain of RNA polymerase II large subunit (POLR2A; MIM 180660) and mediates 3-prime end processing of small nuclear RNAs U1 (RNU1; MIM 180680) and U2 (RNU2; MIM 180690) (Baillat et al., 2005 [PubMed 16239144]).[supplied by OMIM, Mar 2008]

Gene Name: Integrator Complex Subunit 4

Chromosome: CHR11: 77589765 -77705717

Locus: 11q14.1

Gene Diseases

The INTS4 POLD3 Fusion has been associated with the following diseases:

Disease Name
Breast Invasive Carcinoma

FISH Probe Protocols

Protocol, Procedure, or Form Name Last Modified Download

Customer Publications

There are currently no FISH related publications for this probe.