INTS4-POLD3 Fusion FISH Probe
The INTS4-POLD3 Fusion FISH Probe is used to confirm a fusion of the INTS4 and POLD3 genes. The fusion of the INTS4 and POLD3 genes has been associated with Breast Invasive Carcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| INTS4-POLD3-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| INTS4-POLD3-20-RERE | 20 (40 μL) | 200 μL |
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| INTS4-POLD3-20-REOR | 20 (40 μL) | 200 μL |
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| INTS4-POLD3-20-REGO | 20 (40 μL) | 200 μL |
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| INTS4-POLD3-20-REGR | 20 (40 μL) | 200 μL |
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| INTS4-POLD3-20-REAQ | 20 (40 μL) | 200 μL |
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| INTS4-POLD3-20-ORRE | 20 (40 μL) | 200 μL |
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| INTS4-POLD3-20-OROR | 20 (40 μL) | 200 μL |
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| INTS4-POLD3-20-ORGO | 20 (40 μL) | 200 μL |
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| INTS4-POLD3-20-ORAQ | 20 (40 μL) | 200 μL |
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| INTS4-POLD3-20-GORE | 20 (40 μL) | 200 μL |
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| INTS4-POLD3-20-GOOR | 20 (40 μL) | 200 μL |
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| INTS4-POLD3-20-GOGO | 20 (40 μL) | 200 μL |
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| INTS4-POLD3-20-GOGR | 20 (40 μL) | 200 μL |
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| INTS4-POLD3-20-GOAQ | 20 (40 μL) | 200 μL |
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| INTS4-POLD3-20-GRRE | 20 (40 μL) | 200 μL |
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| INTS4-POLD3-20-GROR | 20 (40 μL) | 200 μL |
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| INTS4-POLD3-20-GRGO | 20 (40 μL) | 200 μL |
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| INTS4-POLD3-20-GRGR | 20 (40 μL) | 200 μL |
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| INTS4-POLD3-20-GRAQ | 20 (40 μL) | 200 μL |
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| INTS4-POLD3-20-AQRE | 20 (40 μL) | 200 μL |
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| INTS4-POLD3-20-AQOR | 20 (40 μL) | 200 μL |
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| INTS4-POLD3-20-AQGO | 20 (40 μL) | 200 μL |
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| INTS4-POLD3-20-AQGR | 20 (40 μL) | 200 μL |
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| INTS4-POLD3-20-AQAQ | 20 (40 μL) | 200 μL |
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POLD3 Gene Summary
This gene encodes the 66-kDa subunit of DNA polymerase delta. DNA polymerase delta possesses both polymerase and 3' to 5' exonuclease activity and plays a critical role in DNA replication and repair. The encoded protein plays a role in regulating the activity of DNA polymerase delta through interactions with other subunits and the processivity cofactor proliferating cell nuclear antigen (PCNA). Alternatively spliced transcript variants have been observed for this gene. [provided by RefSeq, Mar 2012]
Gene Name: DNA Polymerase Delta 3, Accessory Subunit
Chromosome: CHR11: 74303628 -74353765
Locus: 11q13.4
INTS4 Gene Summary
INTS4 is a subunit of the Integrator complex, which associates with the C-terminal domain of RNA polymerase II large subunit (POLR2A; MIM 180660) and mediates 3-prime end processing of small nuclear RNAs U1 (RNU1; MIM 180680) and U2 (RNU2; MIM 180690) (Baillat et al., 2005 [PubMed 16239144]).[supplied by OMIM, Mar 2008]
Gene Name: Integrator Complex Subunit 4
Chromosome: CHR11: 77589765 -77705717
Locus: 11q14.1
Gene Diseases
The INTS4 POLD3 Fusion has been associated with the following diseases:
| Disease Name |
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| Breast Invasive Carcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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