INTS4-GAB2 Fusion FISH Probe
The INTS4-GAB2 Fusion FISH Probe is used to confirm a fusion of the INTS4 and GAB2 genes. The fusion of the INTS4 and GAB2 genes has been associated with Breast Invasive Carcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| INTS4-GAB2-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| INTS4-GAB2-20-RERE | 20 (40 μL) | 200 μL |
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| INTS4-GAB2-20-REOR | 20 (40 μL) | 200 μL |
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| INTS4-GAB2-20-REGO | 20 (40 μL) | 200 μL |
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| INTS4-GAB2-20-REGR | 20 (40 μL) | 200 μL |
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| INTS4-GAB2-20-REAQ | 20 (40 μL) | 200 μL |
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| INTS4-GAB2-20-ORRE | 20 (40 μL) | 200 μL |
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| INTS4-GAB2-20-OROR | 20 (40 μL) | 200 μL |
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| INTS4-GAB2-20-ORGO | 20 (40 μL) | 200 μL |
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| INTS4-GAB2-20-ORAQ | 20 (40 μL) | 200 μL |
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| INTS4-GAB2-20-GORE | 20 (40 μL) | 200 μL |
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| INTS4-GAB2-20-GOOR | 20 (40 μL) | 200 μL |
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| INTS4-GAB2-20-GOGO | 20 (40 μL) | 200 μL |
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| INTS4-GAB2-20-GOGR | 20 (40 μL) | 200 μL |
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| INTS4-GAB2-20-GOAQ | 20 (40 μL) | 200 μL |
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| INTS4-GAB2-20-GRRE | 20 (40 μL) | 200 μL |
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| INTS4-GAB2-20-GROR | 20 (40 μL) | 200 μL |
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| INTS4-GAB2-20-GRGO | 20 (40 μL) | 200 μL |
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| INTS4-GAB2-20-GRGR | 20 (40 μL) | 200 μL |
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| INTS4-GAB2-20-GRAQ | 20 (40 μL) | 200 μL |
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| INTS4-GAB2-20-AQRE | 20 (40 μL) | 200 μL |
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| INTS4-GAB2-20-AQOR | 20 (40 μL) | 200 μL |
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| INTS4-GAB2-20-AQGO | 20 (40 μL) | 200 μL |
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| INTS4-GAB2-20-AQGR | 20 (40 μL) | 200 μL |
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| INTS4-GAB2-20-AQAQ | 20 (40 μL) | 200 μL |
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GAB2 Gene Summary
This gene is a member of the GRB2-associated binding protein (GAB) gene family. These proteins contain pleckstrin homology (PH) domain, and bind SHP2 tyrosine phosphatase and GRB2 adapter protein. They act as adapters for transmitting various signals in response to stimuli through cytokine and growth factor receptors, and T- and B-cell antigen receptors. The protein encoded by this gene is the principal activator of phosphatidylinositol-3 kinase in response to activation of the high affinity IgE receptor. Two alternatively spliced transcripts encoding different isoforms have been described for this gene. [provided by RefSeq, Nov 2009]
Gene Name: GRB2 Associated Binding Protein 2
Chromosome: CHR11: 77926335 -78128868
Locus: 11q14.1
INTS4 Gene Summary
INTS4 is a subunit of the Integrator complex, which associates with the C-terminal domain of RNA polymerase II large subunit (POLR2A; MIM 180660) and mediates 3-prime end processing of small nuclear RNAs U1 (RNU1; MIM 180680) and U2 (RNU2; MIM 180690) (Baillat et al., 2005 [PubMed 16239144]).[supplied by OMIM, Mar 2008]
Gene Name: Integrator Complex Subunit 4
Chromosome: CHR11: 77589765 -77705717
Locus: 11q14.1
Gene Diseases
The INTS4 GAB2 Fusion has been associated with the following diseases:
| Disease Name |
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| Breast Invasive Carcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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