INTS2-AXIN2 Fusion FISH Probe
The INTS2-AXIN2 Fusion FISH Probe is used to confirm a fusion of the INTS2 and AXIN2 genes. The fusion of the INTS2 and AXIN2 genes has been associated with Breast Invasive Carcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| INTS2-AXIN2-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| INTS2-AXIN2-20-RERE | 20 (40 μL) | 200 μL |
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| INTS2-AXIN2-20-REOR | 20 (40 μL) | 200 μL |
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| INTS2-AXIN2-20-REGO | 20 (40 μL) | 200 μL |
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| INTS2-AXIN2-20-REGR | 20 (40 μL) | 200 μL |
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| INTS2-AXIN2-20-REAQ | 20 (40 μL) | 200 μL |
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| INTS2-AXIN2-20-ORRE | 20 (40 μL) | 200 μL |
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| INTS2-AXIN2-20-OROR | 20 (40 μL) | 200 μL |
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| INTS2-AXIN2-20-ORGO | 20 (40 μL) | 200 μL |
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| INTS2-AXIN2-20-ORAQ | 20 (40 μL) | 200 μL |
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| INTS2-AXIN2-20-GORE | 20 (40 μL) | 200 μL |
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| INTS2-AXIN2-20-GOOR | 20 (40 μL) | 200 μL |
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| INTS2-AXIN2-20-GOGO | 20 (40 μL) | 200 μL |
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| INTS2-AXIN2-20-GOGR | 20 (40 μL) | 200 μL |
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| INTS2-AXIN2-20-GOAQ | 20 (40 μL) | 200 μL |
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| INTS2-AXIN2-20-GRRE | 20 (40 μL) | 200 μL |
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| INTS2-AXIN2-20-GROR | 20 (40 μL) | 200 μL |
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| INTS2-AXIN2-20-GRGO | 20 (40 μL) | 200 μL |
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| INTS2-AXIN2-20-GRGR | 20 (40 μL) | 200 μL |
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| INTS2-AXIN2-20-GRAQ | 20 (40 μL) | 200 μL |
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| INTS2-AXIN2-20-AQRE | 20 (40 μL) | 200 μL |
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| INTS2-AXIN2-20-AQOR | 20 (40 μL) | 200 μL |
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| INTS2-AXIN2-20-AQGO | 20 (40 μL) | 200 μL |
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| INTS2-AXIN2-20-AQGR | 20 (40 μL) | 200 μL |
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| INTS2-AXIN2-20-AQAQ | 20 (40 μL) | 200 μL |
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AXIN2 Gene Summary
The Axin-related protein, Axin2, presumably plays an important role in the regulation of the stability of beta-catenin in the Wnt signaling pathway, like its rodent homologs, mouse conductin/rat axil. In mouse, conductin organizes a multiprotein complex of APC (adenomatous polyposis of the colon), beta-catenin, glycogen synthase kinase 3-beta, and conductin, which leads to the degradation of beta-catenin. Apparently, the deregulation of beta-catenin is an important event in the genesis of a number of malignancies. The AXIN2 gene has been mapped to 17q23-q24, a region that shows frequent loss of heterozygosity in breast cancer, neuroblastoma, and other tumors. Mutations in this gene have been associated with colorectal cancer with defective mismatch repair. [provided by RefSeq, Jul 2008]
Gene Name: Axin 2
Chromosome: CHR17: 63524682 -63557740
Locus: 17q24.1
INTS2 Gene Summary
INTS2 is a subunit of the Integrator complex, which associates with the C-terminal domain of RNA polymerase II large subunit (POLR2A; MIM 180660) and mediates 3-prime end processing of small nuclear RNAs U1 (RNU1; MIM 180680) and U2 (RNU2; MIM 180690) (Baillat et al., 2005 [PubMed 16239144]).[supplied by OMIM, Mar 2008]
Gene Name: Integrator Complex Subunit 2
Chromosome: CHR17: 59942727 -60005377
Locus: 17q23.2
Gene Diseases
The INTS2 AXIN2 Fusion has been associated with the following diseases:
| Disease Name |
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| Breast Invasive Carcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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