INSR-S1PR2 Fusion FISH Probe
The INSR-S1PR2 Fusion FISH Probe is used to confirm a fusion of the INSR and S1PR2 genes. The fusion of the INSR and S1PR2 genes has been associated with Stomach Adenocarcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| INSR-S1PR2-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| INSR-S1PR2-20-RERE | 20 (40 μL) | 200 μL |
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| INSR-S1PR2-20-REOR | 20 (40 μL) | 200 μL |
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| INSR-S1PR2-20-REGO | 20 (40 μL) | 200 μL |
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| INSR-S1PR2-20-REGR | 20 (40 μL) | 200 μL |
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| INSR-S1PR2-20-REAQ | 20 (40 μL) | 200 μL |
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| INSR-S1PR2-20-ORRE | 20 (40 μL) | 200 μL |
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| INSR-S1PR2-20-OROR | 20 (40 μL) | 200 μL |
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| INSR-S1PR2-20-ORGO | 20 (40 μL) | 200 μL |
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| INSR-S1PR2-20-ORAQ | 20 (40 μL) | 200 μL |
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| INSR-S1PR2-20-GORE | 20 (40 μL) | 200 μL |
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| INSR-S1PR2-20-GOOR | 20 (40 μL) | 200 μL |
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| INSR-S1PR2-20-GOGO | 20 (40 μL) | 200 μL |
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| INSR-S1PR2-20-GOGR | 20 (40 μL) | 200 μL |
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| INSR-S1PR2-20-GOAQ | 20 (40 μL) | 200 μL |
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| INSR-S1PR2-20-GRRE | 20 (40 μL) | 200 μL |
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| INSR-S1PR2-20-GROR | 20 (40 μL) | 200 μL |
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| INSR-S1PR2-20-GRGO | 20 (40 μL) | 200 μL |
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| INSR-S1PR2-20-GRGR | 20 (40 μL) | 200 μL |
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| INSR-S1PR2-20-GRAQ | 20 (40 μL) | 200 μL |
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| INSR-S1PR2-20-AQRE | 20 (40 μL) | 200 μL |
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| INSR-S1PR2-20-AQOR | 20 (40 μL) | 200 μL |
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| INSR-S1PR2-20-AQGO | 20 (40 μL) | 200 μL |
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| INSR-S1PR2-20-AQGR | 20 (40 μL) | 200 μL |
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| INSR-S1PR2-20-AQAQ | 20 (40 μL) | 200 μL |
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INSR Gene Summary
This gene encodes a member of the receptor tyrosine kinase family of proteins. The encoded preproprotein is proteolytically processed to generate alpha and beta subunits that form a heterotetrameric receptor. Binding of insulin or other ligands to this receptor activates the insulin signaling pathway, which regulates glucose uptake and release, as well as the synthesis and storage of carbohydrates, lipids and protein. Mutations in this gene underlie the inherited severe insulin resistance syndromes including type A insulin resistance syndrome, Donohue syndrome and Rabson-Mendenhall syndrome. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2015]
Gene Name: Insulin Receptor
Chromosome: CHR19: 7112265 -7294011
Locus: 19p13.2
S1PR2 Gene Summary
This gene encodes a member of the G protein-coupled receptors, as well as the EDG family of proteins. The encoded protein is a receptor for sphingosine 1-phosphate, which participates in cell proliferation, survival, and transcriptional activation. Defects in this gene have been associated with congenital profound deafness. [provided by RefSeq, Mar 2016]
Gene Name: Sphingosine-1-phosphate Receptor 2
Chromosome: CHR19: 10332108 -10341948
Locus: 19p13.2
Gene Diseases
The INSR S1PR2 Fusion has been associated with the following diseases:
| Disease Name |
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| Stomach Adenocarcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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