INSIG1-DPP6 Fusion FISH Probe
The INSIG1-DPP6 Fusion FISH Probe is used to confirm a fusion of the INSIG1 and DPP6 genes. The fusion of the INSIG1 and DPP6 genes has been associated with Breast Invasive Carcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| INSIG1-DPP6-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| INSIG1-DPP6-20-RERE | 20 (40 μL) | 200 μL |
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| INSIG1-DPP6-20-REOR | 20 (40 μL) | 200 μL |
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| INSIG1-DPP6-20-REGO | 20 (40 μL) | 200 μL |
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| INSIG1-DPP6-20-REGR | 20 (40 μL) | 200 μL |
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| INSIG1-DPP6-20-REAQ | 20 (40 μL) | 200 μL |
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| INSIG1-DPP6-20-ORRE | 20 (40 μL) | 200 μL |
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| INSIG1-DPP6-20-OROR | 20 (40 μL) | 200 μL |
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| INSIG1-DPP6-20-ORGO | 20 (40 μL) | 200 μL |
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| INSIG1-DPP6-20-ORAQ | 20 (40 μL) | 200 μL |
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| INSIG1-DPP6-20-GORE | 20 (40 μL) | 200 μL |
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| INSIG1-DPP6-20-GOOR | 20 (40 μL) | 200 μL |
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| INSIG1-DPP6-20-GOGO | 20 (40 μL) | 200 μL |
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| INSIG1-DPP6-20-GOGR | 20 (40 μL) | 200 μL |
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| INSIG1-DPP6-20-GOAQ | 20 (40 μL) | 200 μL |
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| INSIG1-DPP6-20-GRRE | 20 (40 μL) | 200 μL |
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| INSIG1-DPP6-20-GROR | 20 (40 μL) | 200 μL |
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| INSIG1-DPP6-20-GRGO | 20 (40 μL) | 200 μL |
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| INSIG1-DPP6-20-GRGR | 20 (40 μL) | 200 μL |
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| INSIG1-DPP6-20-GRAQ | 20 (40 μL) | 200 μL |
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| INSIG1-DPP6-20-AQRE | 20 (40 μL) | 200 μL |
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| INSIG1-DPP6-20-AQOR | 20 (40 μL) | 200 μL |
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| INSIG1-DPP6-20-AQGO | 20 (40 μL) | 200 μL |
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| INSIG1-DPP6-20-AQGR | 20 (40 μL) | 200 μL |
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| INSIG1-DPP6-20-AQAQ | 20 (40 μL) | 200 μL |
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DPP6 Gene Summary
This gene encodes a single-pass type II membrane protein that is a member of the peptidase S9B family of serine proteases. This protein has no detectable protease activity, most likely due to the absence of the conserved serine residue normally present in the catalytic domain of serine proteases. However, it does bind specific voltage-gated potassium channels and alters their expression and biophysical properties. Variations in this gene may be associated with susceptibility to amyotrophic lateral sclerosis and with idiopathic ventricular fibrillation. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Mar 2014]
Gene Name: Dipeptidyl Peptidase Like 6
Chromosome: CHR7: 153584418 -154685995
Locus: 7q36.2
INSIG1 Gene Summary
This gene encodes an endoplasmic reticulum membrane protein that regulates cholesterol metabolism, lipogenesis, and glucose homeostasis. The encoded protein has six transmembrane helices which contain an effector protein binding site. It binds the sterol-sensing domains of sterol regulatory element-binding protein (SREBP) cleavage-activating protein (SCAP) and 3-hydroxy-3-methylglutaryl-coenzyme A reductase (HMG-CoA reductase), and is essential for the sterol-mediated trafficking of these two proteins. It promotes the endoplasmic reticulum retention of SCAP and the ubiquitin-mediated degradation of HMG-CoA reductase. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2016]
Gene Name: Insulin Induced Gene 1
Chromosome: CHR7: 155089485 -155101945
Locus: 7q36.3
Gene Diseases
The INSIG1 DPP6 Fusion has been associated with the following diseases:
| Disease Name |
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| Breast Invasive Carcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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