INPP5F-GRK5 Fusion FISH Probe
The INPP5F-GRK5 Fusion FISH Probe is used to confirm a fusion of the INPP5F and GRK5 genes. The fusion of the INPP5F and GRK5 genes has been associated with Skin Cutaneous Melanoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| INPP5F-GRK5-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| INPP5F-GRK5-20-RERE | 20 (40 μL) | 200 μL |
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| INPP5F-GRK5-20-REOR | 20 (40 μL) | 200 μL |
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| INPP5F-GRK5-20-REGO | 20 (40 μL) | 200 μL |
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| INPP5F-GRK5-20-REGR | 20 (40 μL) | 200 μL |
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| INPP5F-GRK5-20-REAQ | 20 (40 μL) | 200 μL |
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| INPP5F-GRK5-20-ORRE | 20 (40 μL) | 200 μL |
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| INPP5F-GRK5-20-OROR | 20 (40 μL) | 200 μL |
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| INPP5F-GRK5-20-ORGO | 20 (40 μL) | 200 μL |
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| INPP5F-GRK5-20-ORAQ | 20 (40 μL) | 200 μL |
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| INPP5F-GRK5-20-GORE | 20 (40 μL) | 200 μL |
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| INPP5F-GRK5-20-GOOR | 20 (40 μL) | 200 μL |
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| INPP5F-GRK5-20-GOGO | 20 (40 μL) | 200 μL |
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| INPP5F-GRK5-20-GOGR | 20 (40 μL) | 200 μL |
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| INPP5F-GRK5-20-GOAQ | 20 (40 μL) | 200 μL |
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| INPP5F-GRK5-20-GRRE | 20 (40 μL) | 200 μL |
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| INPP5F-GRK5-20-GROR | 20 (40 μL) | 200 μL |
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| INPP5F-GRK5-20-GRGO | 20 (40 μL) | 200 μL |
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| INPP5F-GRK5-20-GRGR | 20 (40 μL) | 200 μL |
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| INPP5F-GRK5-20-GRAQ | 20 (40 μL) | 200 μL |
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| INPP5F-GRK5-20-AQRE | 20 (40 μL) | 200 μL |
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| INPP5F-GRK5-20-AQOR | 20 (40 μL) | 200 μL |
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| INPP5F-GRK5-20-AQGO | 20 (40 μL) | 200 μL |
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| INPP5F-GRK5-20-AQGR | 20 (40 μL) | 200 μL |
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| INPP5F-GRK5-20-AQAQ | 20 (40 μL) | 200 μL |
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GRK5 Gene Summary
This gene encodes a member of the guanine nucleotide-binding protein (G protein)-coupled receptor kinase subfamily of the Ser/Thr protein kinase family. The protein phosphorylates the activated forms of G protein-coupled receptors thus initiating their deactivation. It has also been shown to play a role in regulating the motility of polymorphonuclear leukocytes (PMNs). [provided by RefSeq, Jul 2008]
Gene Name: G Protein-coupled Receptor Kinase 5
Chromosome: CHR10: 120967196 -121215131
Locus: 10q26.11
INPP5F Gene Summary
The protein encoded by this gene is an inositol 1,4,5-trisphosphate (InsP3) 5-phosphatase and contains a Sac domain. The activity of this protein is specific for phosphatidylinositol 4,5-bisphosphate and phosphatidylinositol 3,4,5-trisphosphate. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Aug 2011]
Gene Name: Inositol Polyphosphate-5-phosphatase F
Chromosome: CHR10: 121485558 -121588662
Locus: 10q26.11
Gene Diseases
The INPP5F GRK5 Fusion has been associated with the following diseases:
| Disease Name |
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| Skin Cutaneous Melanoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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