INPP5E-SEC16A Fusion FISH Probe
The INPP5E-SEC16A Fusion FISH Probe is used to confirm a fusion of the INPP5E and SEC16A genes. The fusion of the INPP5E and SEC16A genes has been associated with Lung Squamous Cell Carcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| INPP5E-SEC16A-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| INPP5E-SEC16A-20-RERE | 20 (40 μL) | 200 μL |
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| INPP5E-SEC16A-20-REOR | 20 (40 μL) | 200 μL |
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| INPP5E-SEC16A-20-REGO | 20 (40 μL) | 200 μL |
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| INPP5E-SEC16A-20-REGR | 20 (40 μL) | 200 μL |
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| INPP5E-SEC16A-20-REAQ | 20 (40 μL) | 200 μL |
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| INPP5E-SEC16A-20-ORRE | 20 (40 μL) | 200 μL |
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| INPP5E-SEC16A-20-OROR | 20 (40 μL) | 200 μL |
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| INPP5E-SEC16A-20-ORGO | 20 (40 μL) | 200 μL |
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| INPP5E-SEC16A-20-ORAQ | 20 (40 μL) | 200 μL |
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| INPP5E-SEC16A-20-GORE | 20 (40 μL) | 200 μL |
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| INPP5E-SEC16A-20-GOOR | 20 (40 μL) | 200 μL |
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| INPP5E-SEC16A-20-GOGO | 20 (40 μL) | 200 μL |
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| INPP5E-SEC16A-20-GOGR | 20 (40 μL) | 200 μL |
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| INPP5E-SEC16A-20-GOAQ | 20 (40 μL) | 200 μL |
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| INPP5E-SEC16A-20-GRRE | 20 (40 μL) | 200 μL |
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| INPP5E-SEC16A-20-GROR | 20 (40 μL) | 200 μL |
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| INPP5E-SEC16A-20-GRGO | 20 (40 μL) | 200 μL |
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| INPP5E-SEC16A-20-GRGR | 20 (40 μL) | 200 μL |
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| INPP5E-SEC16A-20-GRAQ | 20 (40 μL) | 200 μL |
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| INPP5E-SEC16A-20-AQRE | 20 (40 μL) | 200 μL |
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| INPP5E-SEC16A-20-AQOR | 20 (40 μL) | 200 μL |
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| INPP5E-SEC16A-20-AQGO | 20 (40 μL) | 200 μL |
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| INPP5E-SEC16A-20-AQGR | 20 (40 μL) | 200 μL |
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| INPP5E-SEC16A-20-AQAQ | 20 (40 μL) | 200 μL |
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SEC16A Gene Summary
This gene encodes a protein that forms part of the Sec16 complex. This protein has a role in protein transport from the endoplasmic reticulum (ER) to the Golgi and mediates COPII vesicle formation at the transitional ER. Alternative splicing results in multiple transcript variants that encode different protein isoforms. [provided by RefSeq, Feb 2013]
Gene Name: SEC16 Homolog A, Endoplasmic Reticulum Export Factor
Chromosome: CHR9: 139334547 -139377507
Locus: 9q34.3
INPP5E Gene Summary
The protein encoded by this gene is an inositol 1,4,5-trisphosphate (InsP3) 5-phosphatase. InsP3 5-phosphatases hydrolyze Ins(1,4,5)P3, which mobilizes intracellular calcium and acts as a second messenger mediating cell responses to various stimulation. Studies of the mouse counterpart suggest that this protein may hydrolyze phosphatidylinositol 3,4,5-trisphosphate and phosphatidylinositol 3,5-bisphosphate on the cytoplasmic Golgi membrane and thereby regulate Golgi-vesicular trafficking. Mutations in this gene cause Joubert syndrome; a clinically and genetically heterogenous group of disorders characterized by midbrain-hindbrain malformation and various associated ciliopathies that include retinal dystrophy, nephronophthisis, liver fibrosis and polydactyly. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jan 2016]
Gene Name: Inositol Polyphosphate-5-phosphatase E
Chromosome: CHR9: 139323066 -139334256
Locus: 9q34.3
Gene Diseases
The INPP5E SEC16A Fusion has been associated with the following diseases:
| Disease Name |
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| Lung Squamous Cell Carcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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