INCENP-CCS Fusion FISH Probe
The INCENP-CCS Fusion FISH Probe is used to confirm a fusion of the INCENP and CCS genes. The fusion of the INCENP and CCS genes has been associated with Lung Squamous Cell Carcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| INCENP-CCS-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| INCENP-CCS-20-RERE | 20 (40 μL) | 200 μL |
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| INCENP-CCS-20-REOR | 20 (40 μL) | 200 μL |
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| INCENP-CCS-20-REGO | 20 (40 μL) | 200 μL |
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| INCENP-CCS-20-REGR | 20 (40 μL) | 200 μL |
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| INCENP-CCS-20-REAQ | 20 (40 μL) | 200 μL |
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| INCENP-CCS-20-ORRE | 20 (40 μL) | 200 μL |
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| INCENP-CCS-20-OROR | 20 (40 μL) | 200 μL |
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| INCENP-CCS-20-ORGO | 20 (40 μL) | 200 μL |
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| INCENP-CCS-20-ORAQ | 20 (40 μL) | 200 μL |
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| INCENP-CCS-20-GORE | 20 (40 μL) | 200 μL |
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| INCENP-CCS-20-GOOR | 20 (40 μL) | 200 μL |
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| INCENP-CCS-20-GOGO | 20 (40 μL) | 200 μL |
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| INCENP-CCS-20-GOGR | 20 (40 μL) | 200 μL |
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| INCENP-CCS-20-GOAQ | 20 (40 μL) | 200 μL |
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| INCENP-CCS-20-GRRE | 20 (40 μL) | 200 μL |
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| INCENP-CCS-20-GROR | 20 (40 μL) | 200 μL |
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| INCENP-CCS-20-GRGO | 20 (40 μL) | 200 μL |
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| INCENP-CCS-20-GRGR | 20 (40 μL) | 200 μL |
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| INCENP-CCS-20-GRAQ | 20 (40 μL) | 200 μL |
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| INCENP-CCS-20-AQRE | 20 (40 μL) | 200 μL |
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| INCENP-CCS-20-AQOR | 20 (40 μL) | 200 μL |
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| INCENP-CCS-20-AQGO | 20 (40 μL) | 200 μL |
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| INCENP-CCS-20-AQGR | 20 (40 μL) | 200 μL |
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| INCENP-CCS-20-AQAQ | 20 (40 μL) | 200 μL |
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INCENP Gene Summary
In mammalian cells, 2 broad groups of centromere-interacting proteins have been described: constitutively binding centromere proteins and 'passenger,' or transiently interacting, proteins (reviewed by Choo, 1997). The constitutive proteins include CENPA (centromere protein A; MIM 117139), CENPB (MIM 117140), CENPC1 (MIM 117141), and CENPD (MIM 117142). The term 'passenger proteins' encompasses a broad collection of proteins that localize to the centromere during specific stages of the cell cycle (Earnshaw and Mackay, 1994 [PubMed 8088460]). These include CENPE (MIM 117143); MCAK (MIM 604538); KID (MIM 603213); cytoplasmic dynein (e.g., MIM 600112); CliPs (e.g., MIM 179838); and CENPF/mitosin (MIM 600236). The inner centromere proteins (INCENPs) (Earnshaw and Cooke, 1991 [PubMed 1860899]), the initial members of the passenger protein group, display a broad localization along chromosomes in the early stages of mitosis but gradually become concentrated at centromeres as the cell cycle progresses into mid-metaphase. During telophase, the proteins are located within the midbody in the intercellular bridge, where they are discarded after cytokinesis (Cutts et al., 1999 [PubMed 10369859]).[supplied by OMIM, Mar 2008]
Gene Name: Inner Centromere Protein
Chromosome: CHR11: 61891444 -61920635
Locus: 11q12.3
CCS Gene Summary
Copper chaperone for superoxide dismutase specifically delivers Cu to copper/zinc superoxide dismutase and may activate copper/zinc superoxide dismutase through direct insertion of the Cu cofactor. [provided by RefSeq, Jul 2008]
Gene Name: Copper Chaperone For Superoxide Dismutase
Chromosome: CHR11: 66360689 -66373490
Locus: 11q13.2
Gene Diseases
The INCENP CCS Fusion has been associated with the following diseases:
| Disease Name |
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| Lung Squamous Cell Carcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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