ILF3-C3 Fusion FISH Probe
The ILF3-C3 Fusion FISH Probe is used to confirm a fusion of the ILF3 and C3 genes. The fusion of the ILF3 and C3 genes has been associated with Breast Invasive Carcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| ILF3-C3-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| ILF3-C3-20-RERE | 20 (40 μL) | 200 μL |
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| ILF3-C3-20-REOR | 20 (40 μL) | 200 μL |
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| ILF3-C3-20-REGO | 20 (40 μL) | 200 μL |
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| ILF3-C3-20-REGR | 20 (40 μL) | 200 μL |
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| ILF3-C3-20-REAQ | 20 (40 μL) | 200 μL |
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| ILF3-C3-20-ORRE | 20 (40 μL) | 200 μL |
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| ILF3-C3-20-OROR | 20 (40 μL) | 200 μL |
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| ILF3-C3-20-ORGO | 20 (40 μL) | 200 μL |
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| ILF3-C3-20-ORAQ | 20 (40 μL) | 200 μL |
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| ILF3-C3-20-GORE | 20 (40 μL) | 200 μL |
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| ILF3-C3-20-GOOR | 20 (40 μL) | 200 μL |
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| ILF3-C3-20-GOGO | 20 (40 μL) | 200 μL |
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| ILF3-C3-20-GOGR | 20 (40 μL) | 200 μL |
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| ILF3-C3-20-GOAQ | 20 (40 μL) | 200 μL |
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| ILF3-C3-20-GRRE | 20 (40 μL) | 200 μL |
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| ILF3-C3-20-GROR | 20 (40 μL) | 200 μL |
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| ILF3-C3-20-GRGO | 20 (40 μL) | 200 μL |
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| ILF3-C3-20-GRGR | 20 (40 μL) | 200 μL |
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| ILF3-C3-20-GRAQ | 20 (40 μL) | 200 μL |
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| ILF3-C3-20-AQRE | 20 (40 μL) | 200 μL |
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| ILF3-C3-20-AQOR | 20 (40 μL) | 200 μL |
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| ILF3-C3-20-AQGO | 20 (40 μL) | 200 μL |
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| ILF3-C3-20-AQGR | 20 (40 μL) | 200 μL |
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| ILF3-C3-20-AQAQ | 20 (40 μL) | 200 μL |
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C3 Gene Summary
Complement component C3 plays a central role in the activation of complement system. Its activation is required for both classical and alternative complement activation pathways. The encoded preproprotein is proteolytically processed to generate alpha and beta subunits that form the mature protein, which is then further processed to generate numerous peptide products. The C3a peptide, also known as the C3a anaphylatoxin, modulates inflammation and possesses antimicrobial activity. Mutations in this gene are associated with atypical hemolytic uremic syndrome and age-related macular degeneration in human patients. [provided by RefSeq, Nov 2015]
Gene Name: Complement C3
Chromosome: CHR19: 6677845 -6720662
Locus: 19p13.3
ILF3 Gene Summary
This gene encodes a double-stranded RNA (dsRNA) binding protein that complexes with other proteins, dsRNAs, small noncoding RNAs, and mRNAs to regulate gene expression and stabilize mRNAs. This protein (NF90, ILF3) forms a heterodimer with a 45 kDa transcription factor (NF45, ILF2) required for T-cell expression of interleukin 2. This complex has been shown to affect the redistribution of nuclear mRNA to the cytoplasm. Knockdown of NF45 or NF90 protein retards cell growth, possibly by inhibition of mRNA stabilization. In contrast, an isoform (NF110) of this gene that is predominantly restricted to the nucleus has only minor effects on cell growth when its levels are reduced. Alternative splicing results in multiple transcript variants encoding distinct isoforms.[provided by RefSeq, Dec 2014]
Gene Name: Interleukin Enhancer Binding Factor 3
Chromosome: CHR19: 10764936 -10803095
Locus: 19p13.2
Gene Diseases
The ILF3 C3 Fusion has been associated with the following diseases:
| Disease Name |
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| Breast Invasive Carcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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