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IL6ST-LAMC2 Fusion FISH Probe

The IL6ST-LAMC2 Fusion FISH Probe is used to confirm a fusion of the IL6ST and LAMC2 genes. The fusion of the IL6ST and LAMC2 genes has been associated with Prostate Adenocarcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.

** This product is for in vitro and research use only. This product is not intended for diagnostic use.

Turnaround Time: 7-10 Business Days    Shipping Time: 1-2 Day Expedited Shipping

SKU Test Kits Buffer Dye Color Order Now
IL6ST-LAMC2-20-ORGR  (Standard Design) 20 (40 μL) 200 μL
IL6ST-LAMC2-20-RERE 20 (40 μL) 200 μL
IL6ST-LAMC2-20-REOR 20 (40 μL) 200 μL
IL6ST-LAMC2-20-REGO 20 (40 μL) 200 μL
IL6ST-LAMC2-20-REGR 20 (40 μL) 200 μL
IL6ST-LAMC2-20-REAQ 20 (40 μL) 200 μL
IL6ST-LAMC2-20-ORRE 20 (40 μL) 200 μL
IL6ST-LAMC2-20-OROR 20 (40 μL) 200 μL
IL6ST-LAMC2-20-ORGO 20 (40 μL) 200 μL
IL6ST-LAMC2-20-ORAQ 20 (40 μL) 200 μL
IL6ST-LAMC2-20-GORE 20 (40 μL) 200 μL
IL6ST-LAMC2-20-GOOR 20 (40 μL) 200 μL
IL6ST-LAMC2-20-GOGO 20 (40 μL) 200 μL
IL6ST-LAMC2-20-GOGR 20 (40 μL) 200 μL
IL6ST-LAMC2-20-GOAQ 20 (40 μL) 200 μL
IL6ST-LAMC2-20-GRRE 20 (40 μL) 200 μL
IL6ST-LAMC2-20-GROR 20 (40 μL) 200 μL
IL6ST-LAMC2-20-GRGO 20 (40 μL) 200 μL
IL6ST-LAMC2-20-GRGR 20 (40 μL) 200 μL
IL6ST-LAMC2-20-GRAQ 20 (40 μL) 200 μL
IL6ST-LAMC2-20-AQRE 20 (40 μL) 200 μL
IL6ST-LAMC2-20-AQOR 20 (40 μL) 200 μL
IL6ST-LAMC2-20-AQGO 20 (40 μL) 200 μL
IL6ST-LAMC2-20-AQGR 20 (40 μL) 200 μL
IL6ST-LAMC2-20-AQAQ 20 (40 μL) 200 μL

IL6ST Gene Summary

The protein encoded by this gene is a signal transducer shared by many cytokines, including interleukin 6 (IL6), ciliary neurotrophic factor (CNTF), leukemia inhibitory factor (LIF), and oncostatin M (OSM). This protein functions as a part of the cytokine receptor complex. The activation of this protein is dependent upon the binding of cytokines to their receptors. vIL6, a protein related to IL6 and encoded by the Kaposi sarcoma-associated herpesvirus, can bypass the interleukin 6 receptor (IL6R) and directly activate this protein. Knockout studies in mice suggest that this gene plays a critical role in regulating myocyte apoptosis. Alternatively spliced transcript variants have been described. A related pseudogene has been identified on chromosome 17. [provided by RefSeq, May 2014]

Gene Name: Interleukin 6 Signal Transducer

Chromosome: CHR5: 55230924 -55290821

Locus: 5q11.2

LAMC2 Gene Summary

Laminins, a family of extracellular matrix glycoproteins, are the major noncollagenous constituent of basement membranes. They have been implicated in a wide variety of biological processes including cell adhesion, differentiation, migration, signaling, neurite outgrowth and metastasis. Laminins, composed of 3 non identical chains: laminin alpha, beta and gamma (formerly A, B1, and B2, respectively), have a cruciform structure consisting of 3 short arms, each formed by a different chain, and a long arm composed of all 3 chains. Each laminin chain is a multidomain protein encoded by a distinct gene. Several isoforms of each chain have been described. Different alpha, beta and gamma chain isomers combine to give rise to different heterotrimeric laminin isoforms which are designated by Arabic numerals in the order of their discovery, i.e. alpha1beta1gamma1 heterotrimer is laminin 1. The biological functions of the different chains and trimer molecules are largely unknown, but some of the chains have been shown to differ with respect to their tissue distribution, presumably reflecting diverse functions in vivo. This gene encodes the gamma chain isoform laminin, gamma 2. The gamma 2 chain, formerly thought to be a truncated version of beta chain (B2t), is highly homologous to the gamma 1 chain; however, it lacks domain VI, and domains V, IV and III are shorter. It is expressed in several fetal tissues but differently from gamma 1, and is specifically localized to epithelial cells in skin, lung and kidney. The gamma 2 chain together with alpha 3 and beta 3 chains constitute laminin 5 (earlier known as kalinin), which is an integral part of the anchoring filaments that connect epithelial cells to the underlying basement membrane. The epithelium-specific expression of the gamma 2 chain implied its role as an epithelium attachment molecule, and mutations in this gene have been associated with junctional epidermolysis bullosa, a skin disease characterized by blisters due to disruption of the epidermal-dermal junction. Two transcript variants resulting from alternative splicing of the 3' terminal exon, and encoding different isoforms of gamma 2 chain, have been described. The two variants are differentially expressed in embryonic tissues, however, the biological significance of the two forms is not known. Transcript variants utilizing alternative polyA_signal have also been noted in literature. [provided by RefSeq, Aug 2011]

Gene Name: Laminin Subunit Gamma 2

Chromosome: CHR1: 183155173 -183214262

Locus: 1q25.3

Gene Diseases

The IL6ST LAMC2 Fusion has been associated with the following diseases:

Disease Name
Prostate Adenocarcinoma

FISH Probe Protocols

Protocol, Procedure, or Form Name Last Modified Download

Customer Publications

There are currently no FISH related publications for this probe.