IL4R-ACMSD Fusion FISH Probe
The IL4R-ACMSD Fusion FISH Probe is used to confirm a fusion of the IL4R and ACMSD genes. The fusion of the IL4R and ACMSD genes has been associated with Sarcoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| IL4R-ACMSD-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| IL4R-ACMSD-20-RERE | 20 (40 μL) | 200 μL |
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| IL4R-ACMSD-20-REOR | 20 (40 μL) | 200 μL |
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| IL4R-ACMSD-20-REGO | 20 (40 μL) | 200 μL |
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| IL4R-ACMSD-20-REGR | 20 (40 μL) | 200 μL |
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| IL4R-ACMSD-20-REAQ | 20 (40 μL) | 200 μL |
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| IL4R-ACMSD-20-ORRE | 20 (40 μL) | 200 μL |
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| IL4R-ACMSD-20-OROR | 20 (40 μL) | 200 μL |
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| IL4R-ACMSD-20-ORGO | 20 (40 μL) | 200 μL |
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| IL4R-ACMSD-20-ORAQ | 20 (40 μL) | 200 μL |
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| IL4R-ACMSD-20-GORE | 20 (40 μL) | 200 μL |
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| IL4R-ACMSD-20-GOOR | 20 (40 μL) | 200 μL |
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| IL4R-ACMSD-20-GOGO | 20 (40 μL) | 200 μL |
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| IL4R-ACMSD-20-GOGR | 20 (40 μL) | 200 μL |
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| IL4R-ACMSD-20-GOAQ | 20 (40 μL) | 200 μL |
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| IL4R-ACMSD-20-GRRE | 20 (40 μL) | 200 μL |
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| IL4R-ACMSD-20-GROR | 20 (40 μL) | 200 μL |
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| IL4R-ACMSD-20-GRGO | 20 (40 μL) | 200 μL |
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| IL4R-ACMSD-20-GRGR | 20 (40 μL) | 200 μL |
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| IL4R-ACMSD-20-GRAQ | 20 (40 μL) | 200 μL |
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| IL4R-ACMSD-20-AQRE | 20 (40 μL) | 200 μL |
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| IL4R-ACMSD-20-AQOR | 20 (40 μL) | 200 μL |
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| IL4R-ACMSD-20-AQGO | 20 (40 μL) | 200 μL |
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| IL4R-ACMSD-20-AQGR | 20 (40 μL) | 200 μL |
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| IL4R-ACMSD-20-AQAQ | 20 (40 μL) | 200 μL |
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IL4R Gene Summary
This gene encodes the alpha chain of the interleukin-4 receptor, a type I transmembrane protein that can bind interleukin 4 and interleukin 13 to regulate IgE production. The encoded protein also can bind interleukin 4 to promote differentiation of Th2 cells. A soluble form of the encoded protein can be produced by proteolysis of the membrane-bound protein, and this soluble form can inhibit IL4-mediated cell proliferation and IL5 upregulation by T-cells. Allelic variations in this gene have been associated with atopy, a condition that can manifest itself as allergic rhinitis, sinusitus, asthma, or eczema. Polymorphisms in this gene are also associated with resistance to human immunodeficiency virus type-1 infection. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Apr 2012]
Gene Name: Interleukin 4 Receptor
Chromosome: CHR16: 27325250 -27376099
Locus: 16p12.1
ACMSD Gene Summary
The neuronal excitotoxin quinolinate is an intermediate in the de novo synthesis pathway of NAD from tryptophan, and has been implicated in the pathogenesis of several neurodegenerative disorders. Quinolinate is derived from alpha-amino-beta-carboxy-muconate-epsilon-semialdehyde (ACMS). ACMSD (ACMS decarboxylase; EC 4.1.1.45) can divert ACMS to a benign catabolite and thus prevent the accumulation of quinolinate from ACMS.[supplied by OMIM, Oct 2004]
Gene Name: Aminocarboxymuconate Semialdehyde Decarboxylase
Chromosome: CHR2: 135596185 -135659602
Locus: 2q21.3
Gene Diseases
The IL4R ACMSD Fusion has been associated with the following diseases:
| Disease Name |
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| Sarcoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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