IL1RAP-TP63 Fusion FISH Probe
The IL1RAP-TP63 Fusion FISH Probe is used to confirm a fusion of the IL1RAP and TP63 genes. The fusion of the IL1RAP and TP63 genes has been associated with Lung Squamous Cell Carcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| IL1RAP-TP63-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| IL1RAP-TP63-20-RERE | 20 (40 μL) | 200 μL |
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| IL1RAP-TP63-20-REOR | 20 (40 μL) | 200 μL |
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| IL1RAP-TP63-20-REGO | 20 (40 μL) | 200 μL |
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| IL1RAP-TP63-20-REGR | 20 (40 μL) | 200 μL |
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| IL1RAP-TP63-20-REAQ | 20 (40 μL) | 200 μL |
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| IL1RAP-TP63-20-ORRE | 20 (40 μL) | 200 μL |
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| IL1RAP-TP63-20-OROR | 20 (40 μL) | 200 μL |
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| IL1RAP-TP63-20-ORGO | 20 (40 μL) | 200 μL |
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| IL1RAP-TP63-20-ORAQ | 20 (40 μL) | 200 μL |
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| IL1RAP-TP63-20-GORE | 20 (40 μL) | 200 μL |
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| IL1RAP-TP63-20-GOOR | 20 (40 μL) | 200 μL |
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| IL1RAP-TP63-20-GOGO | 20 (40 μL) | 200 μL |
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| IL1RAP-TP63-20-GOGR | 20 (40 μL) | 200 μL |
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| IL1RAP-TP63-20-GOAQ | 20 (40 μL) | 200 μL |
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| IL1RAP-TP63-20-GRRE | 20 (40 μL) | 200 μL |
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| IL1RAP-TP63-20-GROR | 20 (40 μL) | 200 μL |
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| IL1RAP-TP63-20-GRGO | 20 (40 μL) | 200 μL |
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| IL1RAP-TP63-20-GRGR | 20 (40 μL) | 200 μL |
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| IL1RAP-TP63-20-GRAQ | 20 (40 μL) | 200 μL |
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| IL1RAP-TP63-20-AQRE | 20 (40 μL) | 200 μL |
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| IL1RAP-TP63-20-AQOR | 20 (40 μL) | 200 μL |
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| IL1RAP-TP63-20-AQGO | 20 (40 μL) | 200 μL |
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| IL1RAP-TP63-20-AQGR | 20 (40 μL) | 200 μL |
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| IL1RAP-TP63-20-AQAQ | 20 (40 μL) | 200 μL |
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IL1RAP Gene Summary
Interleukin 1 induces synthesis of acute phase and proinflammatory proteins during infection, tissue damage, or stress, by forming a complex at the cell membrane with an interleukin 1 receptor and an accessory protein. This gene encodes the interleukin 1 receptor accessory protein. The protein is a necessary part of the interleukin 1 receptor complex which initiates signalling events that result in the activation of interleukin 1-responsive genes. Alternative splicing of this gene results in two transcript variants encoding two different isoforms, one membrane-bound and one soluble. The ratio of soluble to membrane-bound forms increases during acute-phase induction or stress. [provided by RefSeq, Nov 2009]
Gene Name: Interleukin 1 Receptor Accessory Protein
Chromosome: CHR3: 190231839 -190374986
Locus: 3q28
TP63 Gene Summary
This gene encodes a member of the p53 family of transcription factors. The functional domains of p53 family proteins include an N-terminal transactivation domain, a central DNA-binding domain and an oligomerization domain. Alternative splicing of this gene and the use of alternative promoters results in multiple transcript variants encoding different isoforms that vary in their functional properties. These isoforms function during skin development and maintenance, adult stem/progenitor cell regulation, heart development and premature aging. Some isoforms have been found to protect the germline by eliminating oocytes or testicular germ cells that have suffered DNA damage. Mutations in this gene are associated with ectodermal dysplasia, and cleft lip/palate syndrome 3 (EEC3); split-hand/foot malformation 4 (SHFM4); ankyloblepharon-ectodermal defects-cleft lip/palate; ADULT syndrome (acro-dermato-ungual-lacrimal-tooth); limb-mammary syndrome; Rap-Hodgkin syndrome (RHS); and orofacial cleft 8. [provided by RefSeq, Aug 2016]
Gene Name: Tumor Protein P63
Chromosome: CHR3: 189349215 -189615068
Locus: 3q28
Gene Diseases
The IL1RAP TP63 Fusion has been associated with the following diseases:
| Disease Name |
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| Lung Squamous Cell Carcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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