IL1RAP-SIRPG Fusion FISH Probe
The IL1RAP-SIRPG Fusion FISH Probe is used to confirm a fusion of the IL1RAP and SIRPG genes. The fusion of the IL1RAP and SIRPG genes has been associated with Cholangiocarcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| IL1RAP-SIRPG-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| IL1RAP-SIRPG-20-RERE | 20 (40 μL) | 200 μL |
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| IL1RAP-SIRPG-20-REOR | 20 (40 μL) | 200 μL |
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| IL1RAP-SIRPG-20-REGO | 20 (40 μL) | 200 μL |
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| IL1RAP-SIRPG-20-REGR | 20 (40 μL) | 200 μL |
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| IL1RAP-SIRPG-20-REAQ | 20 (40 μL) | 200 μL |
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| IL1RAP-SIRPG-20-ORRE | 20 (40 μL) | 200 μL |
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| IL1RAP-SIRPG-20-OROR | 20 (40 μL) | 200 μL |
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| IL1RAP-SIRPG-20-ORGO | 20 (40 μL) | 200 μL |
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| IL1RAP-SIRPG-20-ORAQ | 20 (40 μL) | 200 μL |
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| IL1RAP-SIRPG-20-GORE | 20 (40 μL) | 200 μL |
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| IL1RAP-SIRPG-20-GOOR | 20 (40 μL) | 200 μL |
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| IL1RAP-SIRPG-20-GOGO | 20 (40 μL) | 200 μL |
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| IL1RAP-SIRPG-20-GOGR | 20 (40 μL) | 200 μL |
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| IL1RAP-SIRPG-20-GOAQ | 20 (40 μL) | 200 μL |
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| IL1RAP-SIRPG-20-GRRE | 20 (40 μL) | 200 μL |
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| IL1RAP-SIRPG-20-GROR | 20 (40 μL) | 200 μL |
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| IL1RAP-SIRPG-20-GRGO | 20 (40 μL) | 200 μL |
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| IL1RAP-SIRPG-20-GRGR | 20 (40 μL) | 200 μL |
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| IL1RAP-SIRPG-20-GRAQ | 20 (40 μL) | 200 μL |
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| IL1RAP-SIRPG-20-AQRE | 20 (40 μL) | 200 μL |
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| IL1RAP-SIRPG-20-AQOR | 20 (40 μL) | 200 μL |
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| IL1RAP-SIRPG-20-AQGO | 20 (40 μL) | 200 μL |
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| IL1RAP-SIRPG-20-AQGR | 20 (40 μL) | 200 μL |
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| IL1RAP-SIRPG-20-AQAQ | 20 (40 μL) | 200 μL |
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IL1RAP Gene Summary
Interleukin 1 induces synthesis of acute phase and proinflammatory proteins during infection, tissue damage, or stress, by forming a complex at the cell membrane with an interleukin 1 receptor and an accessory protein. This gene encodes the interleukin 1 receptor accessory protein. The protein is a necessary part of the interleukin 1 receptor complex which initiates signalling events that result in the activation of interleukin 1-responsive genes. Alternative splicing of this gene results in two transcript variants encoding two different isoforms, one membrane-bound and one soluble. The ratio of soluble to membrane-bound forms increases during acute-phase induction or stress. [provided by RefSeq, Nov 2009]
Gene Name: Interleukin 1 Receptor Accessory Protein
Chromosome: CHR3: 190231839 -190374986
Locus: 3q28
SIRPG Gene Summary
The protein encoded by this gene is a member of the signal-regulatory protein (SIRP) family, and also belongs to the immunoglobulin superfamily. SIRP family members are receptor-type transmembrane glycoproteins known to be involved in the negative regulation of receptor tyrosine kinase-coupled signaling processes. Alternatively spliced transcript variants encoding different isoforms have been described. [provided by RefSeq, Jul 2008]
Gene Name: Signal Regulatory Protein Gamma
Chromosome: CHR20: 1609797 -1638425
Locus: 20p13
Gene Diseases
The IL1RAP SIRPG Fusion has been associated with the following diseases:
| Disease Name |
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| Cholangiocarcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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