IL1R1-IL1R2 Fusion FISH Probe
The IL1R1-IL1R2 Fusion FISH Probe is used to confirm a fusion of the IL1R1 and IL1R2 genes. The fusion of the IL1R1 and IL1R2 genes has been associated with Lung Adenocarcinoma, Breast Invasive Carcinoma, and Liver Hepatocellular Carcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| IL1R1-IL1R2-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| IL1R1-IL1R2-20-RERE | 20 (40 μL) | 200 μL |
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| IL1R1-IL1R2-20-REOR | 20 (40 μL) | 200 μL |
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| IL1R1-IL1R2-20-REGO | 20 (40 μL) | 200 μL |
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| IL1R1-IL1R2-20-REGR | 20 (40 μL) | 200 μL |
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| IL1R1-IL1R2-20-REAQ | 20 (40 μL) | 200 μL |
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| IL1R1-IL1R2-20-ORRE | 20 (40 μL) | 200 μL |
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| IL1R1-IL1R2-20-OROR | 20 (40 μL) | 200 μL |
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| IL1R1-IL1R2-20-ORGO | 20 (40 μL) | 200 μL |
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| IL1R1-IL1R2-20-ORAQ | 20 (40 μL) | 200 μL |
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| IL1R1-IL1R2-20-GORE | 20 (40 μL) | 200 μL |
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| IL1R1-IL1R2-20-GOOR | 20 (40 μL) | 200 μL |
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| IL1R1-IL1R2-20-GOGO | 20 (40 μL) | 200 μL |
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| IL1R1-IL1R2-20-GOGR | 20 (40 μL) | 200 μL |
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| IL1R1-IL1R2-20-GOAQ | 20 (40 μL) | 200 μL |
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| IL1R1-IL1R2-20-GRRE | 20 (40 μL) | 200 μL |
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| IL1R1-IL1R2-20-GROR | 20 (40 μL) | 200 μL |
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| IL1R1-IL1R2-20-GRGO | 20 (40 μL) | 200 μL |
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| IL1R1-IL1R2-20-GRGR | 20 (40 μL) | 200 μL |
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| IL1R1-IL1R2-20-GRAQ | 20 (40 μL) | 200 μL |
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| IL1R1-IL1R2-20-AQRE | 20 (40 μL) | 200 μL |
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| IL1R1-IL1R2-20-AQOR | 20 (40 μL) | 200 μL |
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| IL1R1-IL1R2-20-AQGO | 20 (40 μL) | 200 μL |
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| IL1R1-IL1R2-20-AQGR | 20 (40 μL) | 200 μL |
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| IL1R1-IL1R2-20-AQAQ | 20 (40 μL) | 200 μL |
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IL1R1 Gene Summary
This gene encodes a cytokine receptor that belongs to the interleukin-1 receptor family. The encoded protein is a receptor for interleukin-1 alpha, interleukin-1 beta, and interleukin-1 receptor antagonist. It is an important mediator involved in many cytokine-induced immune and inflammatory responses. This gene is located in a cluster of related cytokine receptor genes on chromosome 2q12. [provided by RefSeq, Dec 2013]
Gene Name: Interleukin 1 Receptor Type 1
Chromosome: CHR2: 102770401 -102796334
Locus: 2q11.2-q12.1
IL1R2 Gene Summary
The protein encoded by this gene is a cytokine receptor that belongs to the interleukin 1 receptor family. This protein binds interleukin alpha (IL1A), interleukin beta (IL1B), and interleukin 1 receptor, type I(IL1R1/IL1RA), and acts as a decoy receptor that inhibits the activity of its ligands. Interleukin 4 (IL4) is reported to antagonize the activity of interleukin 1 by inducing the expression and release of this cytokine. This gene and three other genes form a cytokine receptor gene cluster on chromosome 2q12. Alternative splicing results in multiple transcript variants and protein isoforms. Alternative splicing produces both membrane-bound and soluble proteins. A soluble protein is also produced by proteolytic cleavage. [provided by RefSeq, May 2012]
Gene Name: Interleukin 1 Receptor Type 2
Chromosome: CHR2: 102608305 -102644884
Locus: 2q11.2
Gene Diseases
The IL1R1 IL1R2 Fusion has been associated with the following diseases:
| Disease Name |
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| Lung Adenocarcinoma |
| Breast Invasive Carcinoma |
| Liver Hepatocellular Carcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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