IKBKB-ANK1 Fusion FISH Probe
The IKBKB-ANK1 Fusion FISH Probe is used to confirm a fusion of the IKBKB and ANK1 genes. The fusion of the IKBKB and ANK1 genes has been associated with Lung Squamous Cell Carcinoma, Breast Invasive Carcinoma, and Pancreatic Adenocarcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| IKBKB-ANK1-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| IKBKB-ANK1-20-RERE | 20 (40 μL) | 200 μL |
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| IKBKB-ANK1-20-REOR | 20 (40 μL) | 200 μL |
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| IKBKB-ANK1-20-REGO | 20 (40 μL) | 200 μL |
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| IKBKB-ANK1-20-REGR | 20 (40 μL) | 200 μL |
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| IKBKB-ANK1-20-REAQ | 20 (40 μL) | 200 μL |
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| IKBKB-ANK1-20-ORRE | 20 (40 μL) | 200 μL |
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| IKBKB-ANK1-20-OROR | 20 (40 μL) | 200 μL |
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| IKBKB-ANK1-20-ORGO | 20 (40 μL) | 200 μL |
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| IKBKB-ANK1-20-ORAQ | 20 (40 μL) | 200 μL |
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| IKBKB-ANK1-20-GORE | 20 (40 μL) | 200 μL |
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| IKBKB-ANK1-20-GOOR | 20 (40 μL) | 200 μL |
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| IKBKB-ANK1-20-GOGO | 20 (40 μL) | 200 μL |
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| IKBKB-ANK1-20-GOGR | 20 (40 μL) | 200 μL |
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| IKBKB-ANK1-20-GOAQ | 20 (40 μL) | 200 μL |
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| IKBKB-ANK1-20-GRRE | 20 (40 μL) | 200 μL |
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| IKBKB-ANK1-20-GROR | 20 (40 μL) | 200 μL |
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| IKBKB-ANK1-20-GRGO | 20 (40 μL) | 200 μL |
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| IKBKB-ANK1-20-GRGR | 20 (40 μL) | 200 μL |
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| IKBKB-ANK1-20-GRAQ | 20 (40 μL) | 200 μL |
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| IKBKB-ANK1-20-AQRE | 20 (40 μL) | 200 μL |
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| IKBKB-ANK1-20-AQOR | 20 (40 μL) | 200 μL |
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| IKBKB-ANK1-20-AQGO | 20 (40 μL) | 200 μL |
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| IKBKB-ANK1-20-AQGR | 20 (40 μL) | 200 μL |
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| IKBKB-ANK1-20-AQAQ | 20 (40 μL) | 200 μL |
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ANK1 Gene Summary
Ankyrins are a family of proteins that link the integral membrane proteins to the underlying spectrin-actin cytoskeleton and play key roles in activities such as cell motility, activation, proliferation, contact and the maintenance of specialized membrane domains. Multiple isoforms of ankyrin with different affinities for various target proteins are expressed in a tissue-specific, developmentally regulated manner. Most ankyrins are typically composed of three structural domains: an amino-terminal domain containing multiple ankyrin repeats; a central region with a highly conserved spectrin binding domain; and a carboxy-terminal regulatory domain which is the least conserved and subject to variation. Ankyrin 1, the prototype of this family, was first discovered in the erythrocytes, but since has also been found in brain and muscles. Mutations in erythrocytic ankyrin 1 have been associated in approximately half of all patients with hereditary spherocytosis. Complex patterns of alternative splicing in the regulatory domain, giving rise to different isoforms of ankyrin 1 have been described. Truncated muscle-specific isoforms of ankyrin 1 resulting from usage of an alternate promoter have also been identified. [provided by RefSeq, Dec 2008]
Gene Name: Ankyrin 1
Chromosome: CHR8: 41510743 -41754280
Locus: 8p11.21
IKBKB Gene Summary
The protein encoded by this gene phosphorylates the inhibitor in the inhibitor/NF-kappa-B complex, causing dissociation of the inhibitor and activation of NF-kappa-B. The encoded protein itself is found in a complex of proteins. Several transcript variants, some protein-coding and some not, have been found for this gene. [provided by RefSeq, Sep 2011]
Gene Name: Inhibitor Of Nuclear Factor Kappa B Kinase Subunit Beta
Chromosome: CHR8: 42128819 -42190171
Locus: 8p11.21
Gene Diseases
The IKBKB ANK1 Fusion has been associated with the following diseases:
| Disease Name |
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| Lung Squamous Cell Carcinoma |
| Breast Invasive Carcinoma |
| Pancreatic Adenocarcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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