IGFBP4-UTRN Fusion FISH Probe
The IGFBP4-UTRN Fusion FISH Probe is used to confirm a fusion of the IGFBP4 and UTRN genes. The fusion of the IGFBP4 and UTRN genes has been associated with Lung Squamous Cell Carcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| IGFBP4-UTRN-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| IGFBP4-UTRN-20-RERE | 20 (40 μL) | 200 μL |
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| IGFBP4-UTRN-20-REOR | 20 (40 μL) | 200 μL |
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| IGFBP4-UTRN-20-REGO | 20 (40 μL) | 200 μL |
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| IGFBP4-UTRN-20-REGR | 20 (40 μL) | 200 μL |
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| IGFBP4-UTRN-20-REAQ | 20 (40 μL) | 200 μL |
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| IGFBP4-UTRN-20-ORRE | 20 (40 μL) | 200 μL |
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| IGFBP4-UTRN-20-OROR | 20 (40 μL) | 200 μL |
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| IGFBP4-UTRN-20-ORGO | 20 (40 μL) | 200 μL |
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| IGFBP4-UTRN-20-ORAQ | 20 (40 μL) | 200 μL |
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| IGFBP4-UTRN-20-GORE | 20 (40 μL) | 200 μL |
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| IGFBP4-UTRN-20-GOOR | 20 (40 μL) | 200 μL |
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| IGFBP4-UTRN-20-GOGO | 20 (40 μL) | 200 μL |
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| IGFBP4-UTRN-20-GOGR | 20 (40 μL) | 200 μL |
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| IGFBP4-UTRN-20-GOAQ | 20 (40 μL) | 200 μL |
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| IGFBP4-UTRN-20-GRRE | 20 (40 μL) | 200 μL |
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| IGFBP4-UTRN-20-GROR | 20 (40 μL) | 200 μL |
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| IGFBP4-UTRN-20-GRGO | 20 (40 μL) | 200 μL |
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| IGFBP4-UTRN-20-GRGR | 20 (40 μL) | 200 μL |
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| IGFBP4-UTRN-20-GRAQ | 20 (40 μL) | 200 μL |
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| IGFBP4-UTRN-20-AQRE | 20 (40 μL) | 200 μL |
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| IGFBP4-UTRN-20-AQOR | 20 (40 μL) | 200 μL |
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| IGFBP4-UTRN-20-AQGO | 20 (40 μL) | 200 μL |
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| IGFBP4-UTRN-20-AQGR | 20 (40 μL) | 200 μL |
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| IGFBP4-UTRN-20-AQAQ | 20 (40 μL) | 200 μL |
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IGFBP4 Gene Summary
This gene is a member of the insulin-like growth factor binding protein (IGFBP) family and encodes a protein with an IGFBP domain and a thyroglobulin type-I domain. The protein binds both insulin-like growth factors (IGFs) I and II and circulates in the plasma in both glycosylated and non-glycosylated forms. Binding of this protein prolongs the half-life of the IGFs and alters their interaction with cell surface receptors. [provided by RefSeq, Jul 2008]
Gene Name: Insulin Like Growth Factor Binding Protein 4
Chromosome: CHR17: 38599675 -38613982
Locus: 17q21.2
UTRN Gene Summary
This gene shares both structural and functional similarities with the dystrophin gene. It contains an actin-binding N-terminus, a triple coiled-coil repeat central region, and a C-terminus that consists of protein-protein interaction motifs which interact with dystroglycan protein components. The protein encoded by this gene is located at the neuromuscular synapse and myotendinous junctions, where it participates in post-synaptic membrane maintenance and acetylcholine receptor clustering. Mouse studies suggest that this gene may serve as a functional substitute for the dystrophin gene and therefore, may serve as a potential therapeutic alternative to muscular dystrophy which is caused by mutations in the dystrophin gene. Alternative splicing of the utrophin gene has been described; however, the full-length nature of these variants has not yet been determined. [provided by RefSeq, Jul 2008]
Gene Name: Utrophin
Chromosome: CHR6: 144612872 -145174170
Locus: 6q24.2
Gene Diseases
The IGFBP4 UTRN Fusion has been associated with the following diseases:
| Disease Name |
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| Lung Squamous Cell Carcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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