IGF2R-WTAP Fusion FISH Probe
The IGF2R-WTAP Fusion FISH Probe is used to confirm a fusion of the IGF2R and WTAP genes. The fusion of the IGF2R and WTAP genes has been associated with Lung Adenocarcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
|---|---|---|---|---|
| IGF2R-WTAP-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
|
|
| IGF2R-WTAP-20-RERE | 20 (40 μL) | 200 μL |
|
|
| IGF2R-WTAP-20-REOR | 20 (40 μL) | 200 μL |
|
|
| IGF2R-WTAP-20-REGO | 20 (40 μL) | 200 μL |
|
|
| IGF2R-WTAP-20-REGR | 20 (40 μL) | 200 μL |
|
|
| IGF2R-WTAP-20-REAQ | 20 (40 μL) | 200 μL |
|
|
| IGF2R-WTAP-20-ORRE | 20 (40 μL) | 200 μL |
|
|
| IGF2R-WTAP-20-OROR | 20 (40 μL) | 200 μL |
|
|
| IGF2R-WTAP-20-ORGO | 20 (40 μL) | 200 μL |
|
|
| IGF2R-WTAP-20-ORAQ | 20 (40 μL) | 200 μL |
|
|
| IGF2R-WTAP-20-GORE | 20 (40 μL) | 200 μL |
|
|
| IGF2R-WTAP-20-GOOR | 20 (40 μL) | 200 μL |
|
|
| IGF2R-WTAP-20-GOGO | 20 (40 μL) | 200 μL |
|
|
| IGF2R-WTAP-20-GOGR | 20 (40 μL) | 200 μL |
|
|
| IGF2R-WTAP-20-GOAQ | 20 (40 μL) | 200 μL |
|
|
| IGF2R-WTAP-20-GRRE | 20 (40 μL) | 200 μL |
|
|
| IGF2R-WTAP-20-GROR | 20 (40 μL) | 200 μL |
|
|
| IGF2R-WTAP-20-GRGO | 20 (40 μL) | 200 μL |
|
|
| IGF2R-WTAP-20-GRGR | 20 (40 μL) | 200 μL |
|
|
| IGF2R-WTAP-20-GRAQ | 20 (40 μL) | 200 μL |
|
|
| IGF2R-WTAP-20-AQRE | 20 (40 μL) | 200 μL |
|
|
| IGF2R-WTAP-20-AQOR | 20 (40 μL) | 200 μL |
|
|
| IGF2R-WTAP-20-AQGO | 20 (40 μL) | 200 μL |
|
|
| IGF2R-WTAP-20-AQGR | 20 (40 μL) | 200 μL |
|
|
| IGF2R-WTAP-20-AQAQ | 20 (40 μL) | 200 μL |
|
IGF2R Gene Summary
This gene encodes a receptor for both insulin-like growth factor 2 and mannose 6-phosphate. The binding sites for each ligand are located on different segments of the protein. This receptor has various functions, including in the intracellular trafficking of lysosomal enzymes, the activation of transforming growth factor beta, and the degradation of insulin-like growth factor 2. Mutation or loss of heterozygosity of this gene has been association with risk of hepatocellular carcinoma. The orthologous mouse gene is imprinted and shows exclusive expression from the maternal allele; however, imprinting of the human gene may be polymorphic, as only a minority of individuals showed biased expression from the maternal allele (PMID:8267611). [provided by RefSeq, Nov 2015]
Gene Name: Insulin Like Growth Factor 2 Receptor
Chromosome: CHR6: 160390130 -160527583
Locus: 6q25.3
WTAP Gene Summary
The Wilms tumor suppressor gene WT1 appears to play a role in both transcriptional and posttranscriptional regulation of certain cellular genes. This gene encodes a WT1-associating protein, which is a ubiquitously expressed nuclear protein. Like WT1 protein, this protein is localized throughout the nucleoplasm as well as in speckles and partially colocalizes with splicing factors. Alternative splicing of this gene results in several transcript variants encoding three different isoforms. [provided by RefSeq, Jul 2012]
Gene Name: WT1 Associated Protein
Chromosome: CHR6: 160148151 -160177351
Locus: 6q25.3
Gene Diseases
The IGF2R WTAP Fusion has been associated with the following diseases:
| Disease Name |
|---|
| Lung Adenocarcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
|---|