IGF2R-QKI Fusion FISH Probe
The IGF2R-QKI Fusion FISH Probe is used to confirm a fusion of the IGF2R and QKI genes. The fusion of the IGF2R and QKI genes has been associated with Skin Cutaneous Melanoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| IGF2R-QKI-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| IGF2R-QKI-20-RERE | 20 (40 μL) | 200 μL |
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| IGF2R-QKI-20-REOR | 20 (40 μL) | 200 μL |
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| IGF2R-QKI-20-REGO | 20 (40 μL) | 200 μL |
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| IGF2R-QKI-20-REGR | 20 (40 μL) | 200 μL |
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| IGF2R-QKI-20-REAQ | 20 (40 μL) | 200 μL |
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| IGF2R-QKI-20-ORRE | 20 (40 μL) | 200 μL |
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| IGF2R-QKI-20-OROR | 20 (40 μL) | 200 μL |
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| IGF2R-QKI-20-ORGO | 20 (40 μL) | 200 μL |
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| IGF2R-QKI-20-ORAQ | 20 (40 μL) | 200 μL |
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| IGF2R-QKI-20-GORE | 20 (40 μL) | 200 μL |
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| IGF2R-QKI-20-GOOR | 20 (40 μL) | 200 μL |
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| IGF2R-QKI-20-GOGO | 20 (40 μL) | 200 μL |
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| IGF2R-QKI-20-GOGR | 20 (40 μL) | 200 μL |
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| IGF2R-QKI-20-GOAQ | 20 (40 μL) | 200 μL |
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| IGF2R-QKI-20-GRRE | 20 (40 μL) | 200 μL |
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| IGF2R-QKI-20-GROR | 20 (40 μL) | 200 μL |
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| IGF2R-QKI-20-GRGO | 20 (40 μL) | 200 μL |
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| IGF2R-QKI-20-GRGR | 20 (40 μL) | 200 μL |
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| IGF2R-QKI-20-GRAQ | 20 (40 μL) | 200 μL |
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| IGF2R-QKI-20-AQRE | 20 (40 μL) | 200 μL |
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| IGF2R-QKI-20-AQOR | 20 (40 μL) | 200 μL |
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| IGF2R-QKI-20-AQGO | 20 (40 μL) | 200 μL |
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| IGF2R-QKI-20-AQGR | 20 (40 μL) | 200 μL |
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| IGF2R-QKI-20-AQAQ | 20 (40 μL) | 200 μL |
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IGF2R Gene Summary
This gene encodes a receptor for both insulin-like growth factor 2 and mannose 6-phosphate. The binding sites for each ligand are located on different segments of the protein. This receptor has various functions, including in the intracellular trafficking of lysosomal enzymes, the activation of transforming growth factor beta, and the degradation of insulin-like growth factor 2. Mutation or loss of heterozygosity of this gene has been association with risk of hepatocellular carcinoma. The orthologous mouse gene is imprinted and shows exclusive expression from the maternal allele; however, imprinting of the human gene may be polymorphic, as only a minority of individuals showed biased expression from the maternal allele (PMID:8267611). [provided by RefSeq, Nov 2015]
Gene Name: Insulin Like Growth Factor 2 Receptor
Chromosome: CHR6: 160390130 -160527583
Locus: 6q25.3
QKI Gene Summary
The protein encoded by this gene is an RNA-binding protein that regulates pre-mRNA splicing, export of mRNAs from the nucleus, protein translation, and mRNA stability. The encoded protein is involved in myelinization and oligodendrocyte differentiation and may play a role in schizophrenia. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2014]
Gene Name: QKI, KH Domain Containing RNA Binding
Chromosome: CHR6: 163835674 -163999628
Locus: 6q26
Gene Diseases
The IGF2R QKI Fusion has been associated with the following diseases:
| Disease Name |
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| Skin Cutaneous Melanoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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