IGF2R-ARFGEF2 Fusion FISH Probe
The IGF2R-ARFGEF2 Fusion FISH Probe is used to confirm a fusion of the IGF2R and ARFGEF2 genes. The fusion of the IGF2R and ARFGEF2 genes has been associated with Thyroid Carcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| IGF2R-ARFGEF2-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| IGF2R-ARFGEF2-20-RERE | 20 (40 μL) | 200 μL |
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| IGF2R-ARFGEF2-20-REOR | 20 (40 μL) | 200 μL |
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| IGF2R-ARFGEF2-20-REGO | 20 (40 μL) | 200 μL |
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| IGF2R-ARFGEF2-20-REGR | 20 (40 μL) | 200 μL |
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| IGF2R-ARFGEF2-20-REAQ | 20 (40 μL) | 200 μL |
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| IGF2R-ARFGEF2-20-ORRE | 20 (40 μL) | 200 μL |
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| IGF2R-ARFGEF2-20-OROR | 20 (40 μL) | 200 μL |
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| IGF2R-ARFGEF2-20-ORGO | 20 (40 μL) | 200 μL |
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| IGF2R-ARFGEF2-20-ORAQ | 20 (40 μL) | 200 μL |
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| IGF2R-ARFGEF2-20-GORE | 20 (40 μL) | 200 μL |
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| IGF2R-ARFGEF2-20-GOOR | 20 (40 μL) | 200 μL |
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| IGF2R-ARFGEF2-20-GOGO | 20 (40 μL) | 200 μL |
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| IGF2R-ARFGEF2-20-GOGR | 20 (40 μL) | 200 μL |
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| IGF2R-ARFGEF2-20-GOAQ | 20 (40 μL) | 200 μL |
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| IGF2R-ARFGEF2-20-GRRE | 20 (40 μL) | 200 μL |
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| IGF2R-ARFGEF2-20-GROR | 20 (40 μL) | 200 μL |
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| IGF2R-ARFGEF2-20-GRGO | 20 (40 μL) | 200 μL |
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| IGF2R-ARFGEF2-20-GRGR | 20 (40 μL) | 200 μL |
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| IGF2R-ARFGEF2-20-GRAQ | 20 (40 μL) | 200 μL |
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| IGF2R-ARFGEF2-20-AQRE | 20 (40 μL) | 200 μL |
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| IGF2R-ARFGEF2-20-AQOR | 20 (40 μL) | 200 μL |
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| IGF2R-ARFGEF2-20-AQGO | 20 (40 μL) | 200 μL |
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| IGF2R-ARFGEF2-20-AQGR | 20 (40 μL) | 200 μL |
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| IGF2R-ARFGEF2-20-AQAQ | 20 (40 μL) | 200 μL |
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IGF2R Gene Summary
This gene encodes a receptor for both insulin-like growth factor 2 and mannose 6-phosphate. The binding sites for each ligand are located on different segments of the protein. This receptor has various functions, including in the intracellular trafficking of lysosomal enzymes, the activation of transforming growth factor beta, and the degradation of insulin-like growth factor 2. Mutation or loss of heterozygosity of this gene has been association with risk of hepatocellular carcinoma. The orthologous mouse gene is imprinted and shows exclusive expression from the maternal allele; however, imprinting of the human gene may be polymorphic, as only a minority of individuals showed biased expression from the maternal allele (PMID:8267611). [provided by RefSeq, Nov 2015]
Gene Name: Insulin Like Growth Factor 2 Receptor
Chromosome: CHR6: 160390130 -160527583
Locus: 6q25.3
ARFGEF2 Gene Summary
ADP-ribosylation factors (ARFs) play an important role in intracellular vesicular trafficking. The protein encoded by this gene is involved in the activation of ARFs by accelerating replacement of bound GDP with GTP and is involved in Golgi transport. It contains a Sec7 domain, which may be responsible for its guanine-nucleotide exchange activity and also brefeldin A inhibition. [provided by RefSeq, Jul 2008]
Gene Name: ADP Ribosylation Factor Guanine Nucleotide Exchange Factor 2
Chromosome: CHR20: 47538274 -47653230
Locus: 20q13.13
Gene Diseases
The IGF2R ARFGEF2 Fusion has been associated with the following diseases:
| Disease Name |
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| Thyroid Carcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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