IGF2R-ACVR2A Fusion FISH Probe
The IGF2R-ACVR2A Fusion FISH Probe is used to confirm a fusion of the IGF2R and ACVR2A genes. The fusion of the IGF2R and ACVR2A genes has been associated with Breast Invasive Carcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| IGF2R-ACVR2A-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| IGF2R-ACVR2A-20-RERE | 20 (40 μL) | 200 μL |
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| IGF2R-ACVR2A-20-REOR | 20 (40 μL) | 200 μL |
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| IGF2R-ACVR2A-20-REGO | 20 (40 μL) | 200 μL |
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| IGF2R-ACVR2A-20-REGR | 20 (40 μL) | 200 μL |
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| IGF2R-ACVR2A-20-REAQ | 20 (40 μL) | 200 μL |
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| IGF2R-ACVR2A-20-ORRE | 20 (40 μL) | 200 μL |
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| IGF2R-ACVR2A-20-OROR | 20 (40 μL) | 200 μL |
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| IGF2R-ACVR2A-20-ORGO | 20 (40 μL) | 200 μL |
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| IGF2R-ACVR2A-20-ORAQ | 20 (40 μL) | 200 μL |
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| IGF2R-ACVR2A-20-GORE | 20 (40 μL) | 200 μL |
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| IGF2R-ACVR2A-20-GOOR | 20 (40 μL) | 200 μL |
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| IGF2R-ACVR2A-20-GOGO | 20 (40 μL) | 200 μL |
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| IGF2R-ACVR2A-20-GOGR | 20 (40 μL) | 200 μL |
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| IGF2R-ACVR2A-20-GOAQ | 20 (40 μL) | 200 μL |
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| IGF2R-ACVR2A-20-GRRE | 20 (40 μL) | 200 μL |
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| IGF2R-ACVR2A-20-GROR | 20 (40 μL) | 200 μL |
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| IGF2R-ACVR2A-20-GRGO | 20 (40 μL) | 200 μL |
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| IGF2R-ACVR2A-20-GRGR | 20 (40 μL) | 200 μL |
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| IGF2R-ACVR2A-20-GRAQ | 20 (40 μL) | 200 μL |
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| IGF2R-ACVR2A-20-AQRE | 20 (40 μL) | 200 μL |
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| IGF2R-ACVR2A-20-AQOR | 20 (40 μL) | 200 μL |
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| IGF2R-ACVR2A-20-AQGO | 20 (40 μL) | 200 μL |
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| IGF2R-ACVR2A-20-AQGR | 20 (40 μL) | 200 μL |
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| IGF2R-ACVR2A-20-AQAQ | 20 (40 μL) | 200 μL |
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ACVR2A Gene Summary
This gene encodes a receptor that mediates the functions of activins, which are members of the transforming growth factor-beta (TGF-beta) superfamily involved in diverse biological processes. The encoded protein is a transmembrane serine-threonine kinase receptor which mediates signaling by forming heterodimeric complexes with various combinations of type I and type II receptors and ligands in a cell-specific manner. The encoded type II receptor is primarily involved in ligand-binding and includes an extracellular ligand-binding domain, a transmembrane domain and a cytoplasmic serine-threonine kinase domain. This gene may be associated with susceptibility to preeclampsia, a pregnancy-related disease which can result in maternal and fetal morbidity and mortality. Alternative splicing results in multiple transcript variants of this gene. [provided by RefSeq, Jun 2013]
Gene Name: Activin A Receptor Type 2A
Chromosome: CHR2: 148602569 -148688393
Locus: 2q22.3-q23.1
IGF2R Gene Summary
This gene encodes a receptor for both insulin-like growth factor 2 and mannose 6-phosphate. The binding sites for each ligand are located on different segments of the protein. This receptor has various functions, including in the intracellular trafficking of lysosomal enzymes, the activation of transforming growth factor beta, and the degradation of insulin-like growth factor 2. Mutation or loss of heterozygosity of this gene has been association with risk of hepatocellular carcinoma. The orthologous mouse gene is imprinted and shows exclusive expression from the maternal allele; however, imprinting of the human gene may be polymorphic, as only a minority of individuals showed biased expression from the maternal allele (PMID:8267611). [provided by RefSeq, Nov 2015]
Gene Name: Insulin Like Growth Factor 2 Receptor
Chromosome: CHR6: 160390130 -160527583
Locus: 6q25.3
Gene Diseases
The IGF2R ACVR2A Fusion has been associated with the following diseases:
| Disease Name |
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| Breast Invasive Carcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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