IGF2-MCM8 Fusion FISH Probe
The IGF2-MCM8 Fusion FISH Probe is used to confirm a fusion of the IGF2 and MCM8 genes. The fusion of the IGF2 and MCM8 genes has been associated with Lung Adenocarcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| IGF2-MCM8-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| IGF2-MCM8-20-RERE | 20 (40 μL) | 200 μL |
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| IGF2-MCM8-20-REOR | 20 (40 μL) | 200 μL |
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| IGF2-MCM8-20-REGO | 20 (40 μL) | 200 μL |
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| IGF2-MCM8-20-REGR | 20 (40 μL) | 200 μL |
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| IGF2-MCM8-20-REAQ | 20 (40 μL) | 200 μL |
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| IGF2-MCM8-20-ORRE | 20 (40 μL) | 200 μL |
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| IGF2-MCM8-20-OROR | 20 (40 μL) | 200 μL |
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| IGF2-MCM8-20-ORGO | 20 (40 μL) | 200 μL |
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| IGF2-MCM8-20-ORAQ | 20 (40 μL) | 200 μL |
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| IGF2-MCM8-20-GORE | 20 (40 μL) | 200 μL |
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| IGF2-MCM8-20-GOOR | 20 (40 μL) | 200 μL |
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| IGF2-MCM8-20-GOGO | 20 (40 μL) | 200 μL |
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| IGF2-MCM8-20-GOGR | 20 (40 μL) | 200 μL |
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| IGF2-MCM8-20-GOAQ | 20 (40 μL) | 200 μL |
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| IGF2-MCM8-20-GRRE | 20 (40 μL) | 200 μL |
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| IGF2-MCM8-20-GROR | 20 (40 μL) | 200 μL |
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| IGF2-MCM8-20-GRGO | 20 (40 μL) | 200 μL |
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| IGF2-MCM8-20-GRGR | 20 (40 μL) | 200 μL |
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| IGF2-MCM8-20-GRAQ | 20 (40 μL) | 200 μL |
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| IGF2-MCM8-20-AQRE | 20 (40 μL) | 200 μL |
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| IGF2-MCM8-20-AQOR | 20 (40 μL) | 200 μL |
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| IGF2-MCM8-20-AQGO | 20 (40 μL) | 200 μL |
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| IGF2-MCM8-20-AQGR | 20 (40 μL) | 200 μL |
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| IGF2-MCM8-20-AQAQ | 20 (40 μL) | 200 μL |
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IGF2 Gene Summary
This gene encodes a member of the insulin family of polypeptide growth factors, which are involved in development and growth. It is an imprinted gene, expressed only from the paternal allele, and epigenetic changes at this locus are associated with Wilms tumour, Beckwith-Wiedemann syndrome, rhabdomyosarcoma, and Silver-Russell syndrome. A read-through INS-IGF2 gene exists, whose 5' region overlaps the INS gene and the 3' region overlaps this gene. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2010]
Gene Name: Insulin Like Growth Factor 2
Chromosome: CHR11: 2150346 -2170833
Locus: 11p15.5
MCM8 Gene Summary
The protein encoded by this gene is one of the highly conserved mini-chromosome maintenance proteins (MCM) that are essential for the initiation of eukaryotic genome replication. The hexameric protein complex formed by the mini-chromosome maintenance proteins is a key component of the pre-replication complex and may be involved in the formation of replication forks and in the recruitment of other DNA replication related proteins. This protein contains the central domain that is conserved among the mini-chromosome maintenance proteins. The encoded protein may interact with other mini-chromosome maintenance proteins and play a role in DNA replication. This gene may be associated with length of reproductive lifespan and menopause. Alternatively spliced transcript variants encoding distinct isoforms have been described. [provided by RefSeq, Jul 2013]
Gene Name: Minichromosome Maintenance 8 Homologous Recombination Repair Factor
Chromosome: CHR20: 5931297 -5975831
Locus: 20p12.3
Gene Diseases
The IGF2 MCM8 Fusion has been associated with the following diseases:
| Disease Name |
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| Lung Adenocarcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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