IGF1R-RAB27A Fusion FISH Probe
The IGF1R-RAB27A Fusion FISH Probe is used to confirm a fusion of the IGF1R and RAB27A genes. The fusion of the IGF1R and RAB27A genes has been associated with Breast Invasive Carcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| IGF1R-RAB27A-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| IGF1R-RAB27A-20-RERE | 20 (40 μL) | 200 μL |
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| IGF1R-RAB27A-20-REOR | 20 (40 μL) | 200 μL |
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| IGF1R-RAB27A-20-REGO | 20 (40 μL) | 200 μL |
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| IGF1R-RAB27A-20-REGR | 20 (40 μL) | 200 μL |
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| IGF1R-RAB27A-20-REAQ | 20 (40 μL) | 200 μL |
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| IGF1R-RAB27A-20-ORRE | 20 (40 μL) | 200 μL |
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| IGF1R-RAB27A-20-OROR | 20 (40 μL) | 200 μL |
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| IGF1R-RAB27A-20-ORGO | 20 (40 μL) | 200 μL |
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| IGF1R-RAB27A-20-ORAQ | 20 (40 μL) | 200 μL |
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| IGF1R-RAB27A-20-GORE | 20 (40 μL) | 200 μL |
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| IGF1R-RAB27A-20-GOOR | 20 (40 μL) | 200 μL |
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| IGF1R-RAB27A-20-GOGO | 20 (40 μL) | 200 μL |
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| IGF1R-RAB27A-20-GOGR | 20 (40 μL) | 200 μL |
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| IGF1R-RAB27A-20-GOAQ | 20 (40 μL) | 200 μL |
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| IGF1R-RAB27A-20-GRRE | 20 (40 μL) | 200 μL |
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| IGF1R-RAB27A-20-GROR | 20 (40 μL) | 200 μL |
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| IGF1R-RAB27A-20-GRGO | 20 (40 μL) | 200 μL |
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| IGF1R-RAB27A-20-GRGR | 20 (40 μL) | 200 μL |
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| IGF1R-RAB27A-20-GRAQ | 20 (40 μL) | 200 μL |
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| IGF1R-RAB27A-20-AQRE | 20 (40 μL) | 200 μL |
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| IGF1R-RAB27A-20-AQOR | 20 (40 μL) | 200 μL |
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| IGF1R-RAB27A-20-AQGO | 20 (40 μL) | 200 μL |
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| IGF1R-RAB27A-20-AQGR | 20 (40 μL) | 200 μL |
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| IGF1R-RAB27A-20-AQAQ | 20 (40 μL) | 200 μL |
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IGF1R Gene Summary
This receptor binds insulin-like growth factor with a high affinity. It has tyrosine kinase activity. The insulin-like growth factor I receptor plays a critical role in transformation events. Cleavage of the precursor generates alpha and beta subunits. It is highly overexpressed in most malignant tissues where it functions as an anti-apoptotic agent by enhancing cell survival. Alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. [provided by RefSeq, May 2014]
Gene Name: Insulin Like Growth Factor 1 Receptor
Chromosome: CHR15: 99192760 -99507759
Locus: 15q26.3
RAB27A Gene Summary
The protein encoded by this gene belongs to the small GTPase superfamily, Rab family. The protein is membrane-bound and may be involved in protein transport and small GTPase mediated signal transduction. Mutations in this gene are associated with Griscelli syndrome type 2. Alternative splicing occurs at this locus and four transcript variants encoding the same protein have been identified. [provided by RefSeq, Jul 2008]
Gene Name: RAB27A, Member RAS Oncogene Family
Chromosome: CHR15: 55495163 -55582013
Locus: 15q21.3
Gene Diseases
The IGF1R RAB27A Fusion has been associated with the following diseases:
| Disease Name |
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| Breast Invasive Carcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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