IFT74-CACNA2D3 Fusion FISH Probe
The IFT74-CACNA2D3 Fusion FISH Probe is used to confirm a fusion of the IFT74 and CACNA2D3 genes. The fusion of the IFT74 and CACNA2D3 genes has been associated with Thyroid Carcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| IFT74-CACNA2D3-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| IFT74-CACNA2D3-20-RERE | 20 (40 μL) | 200 μL |
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| IFT74-CACNA2D3-20-REOR | 20 (40 μL) | 200 μL |
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| IFT74-CACNA2D3-20-REGO | 20 (40 μL) | 200 μL |
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| IFT74-CACNA2D3-20-REGR | 20 (40 μL) | 200 μL |
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| IFT74-CACNA2D3-20-REAQ | 20 (40 μL) | 200 μL |
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| IFT74-CACNA2D3-20-ORRE | 20 (40 μL) | 200 μL |
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| IFT74-CACNA2D3-20-OROR | 20 (40 μL) | 200 μL |
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| IFT74-CACNA2D3-20-ORGO | 20 (40 μL) | 200 μL |
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| IFT74-CACNA2D3-20-ORAQ | 20 (40 μL) | 200 μL |
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| IFT74-CACNA2D3-20-GORE | 20 (40 μL) | 200 μL |
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| IFT74-CACNA2D3-20-GOOR | 20 (40 μL) | 200 μL |
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| IFT74-CACNA2D3-20-GOGO | 20 (40 μL) | 200 μL |
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| IFT74-CACNA2D3-20-GOGR | 20 (40 μL) | 200 μL |
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| IFT74-CACNA2D3-20-GOAQ | 20 (40 μL) | 200 μL |
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| IFT74-CACNA2D3-20-GRRE | 20 (40 μL) | 200 μL |
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| IFT74-CACNA2D3-20-GROR | 20 (40 μL) | 200 μL |
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| IFT74-CACNA2D3-20-GRGO | 20 (40 μL) | 200 μL |
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| IFT74-CACNA2D3-20-GRGR | 20 (40 μL) | 200 μL |
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| IFT74-CACNA2D3-20-GRAQ | 20 (40 μL) | 200 μL |
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| IFT74-CACNA2D3-20-AQRE | 20 (40 μL) | 200 μL |
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| IFT74-CACNA2D3-20-AQOR | 20 (40 μL) | 200 μL |
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| IFT74-CACNA2D3-20-AQGO | 20 (40 μL) | 200 μL |
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| IFT74-CACNA2D3-20-AQGR | 20 (40 μL) | 200 μL |
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| IFT74-CACNA2D3-20-AQAQ | 20 (40 μL) | 200 μL |
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CACNA2D3 Gene Summary
This gene encodes a member of the alpha-2/delta subunit family, a protein in the voltage-dependent calcium channel complex. Calcium channels mediate the influx of calcium ions into the cell upon membrane polarization and consist of a complex of alpha-1, alpha-2/delta, beta, and gamma subunits in a 1:1:1:1 ratio. Various versions of each of these subunits exist, either expressed from similar genes or the result of alternative splicing. Research on a highly similar protein in rabbit suggests the protein described in this record is cleaved into alpha-2 and delta subunits. Alternate transcriptional splice variants of this gene have been observed but have not been thoroughly characterized. [provided by RefSeq, Jul 2008]
Gene Name: Calcium Voltage-gated Channel Auxiliary Subunit Alpha2delta 3
Chromosome: CHR3: 54156692 -55108584
Locus: 3p21.1-p14.3
IFT74 Gene Summary
This gene encodes a core intraflagellar transport (IFT) protein which belongs to a multi-protein complex involved in the transport of ciliary proteins along axonemal microtubules. IFT proteins are found at the base of the cilium as well as inside the cilium, where they assemble into long arrays between the ciliary base and tip. This protein, together with intraflagellar transport protein 81, binds and transports tubulin within cilia and is required for ciliogenesis. Naturally occurring mutations in this gene are associated with amyotrophic lateral sclerosis--frontotemporal dementia and Bardet-Biedl Syndrome. [provided by RefSeq, Mar 2017]
Gene Name: Intraflagellar Transport 74
Chromosome: CHR9: 26947036 -27062931
Locus: 9p21.2
Gene Diseases
The IFT74 CACNA2D3 Fusion has been associated with the following diseases:
| Disease Name |
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| Thyroid Carcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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