HUWE1-PHF8 Fusion FISH Probe
The HUWE1-PHF8 Fusion FISH Probe is used to confirm a fusion of the HUWE1 and PHF8 genes. The fusion of the HUWE1 and PHF8 genes has been associated with Uterine Corpus Endometrial Carcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| HUWE1-PHF8-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| HUWE1-PHF8-20-RERE | 20 (40 μL) | 200 μL |
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| HUWE1-PHF8-20-REOR | 20 (40 μL) | 200 μL |
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| HUWE1-PHF8-20-REGO | 20 (40 μL) | 200 μL |
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| HUWE1-PHF8-20-REGR | 20 (40 μL) | 200 μL |
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| HUWE1-PHF8-20-REAQ | 20 (40 μL) | 200 μL |
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| HUWE1-PHF8-20-ORRE | 20 (40 μL) | 200 μL |
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| HUWE1-PHF8-20-OROR | 20 (40 μL) | 200 μL |
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| HUWE1-PHF8-20-ORGO | 20 (40 μL) | 200 μL |
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| HUWE1-PHF8-20-ORAQ | 20 (40 μL) | 200 μL |
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| HUWE1-PHF8-20-GORE | 20 (40 μL) | 200 μL |
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| HUWE1-PHF8-20-GOOR | 20 (40 μL) | 200 μL |
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| HUWE1-PHF8-20-GOGO | 20 (40 μL) | 200 μL |
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| HUWE1-PHF8-20-GOGR | 20 (40 μL) | 200 μL |
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| HUWE1-PHF8-20-GOAQ | 20 (40 μL) | 200 μL |
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| HUWE1-PHF8-20-GRRE | 20 (40 μL) | 200 μL |
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| HUWE1-PHF8-20-GROR | 20 (40 μL) | 200 μL |
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| HUWE1-PHF8-20-GRGO | 20 (40 μL) | 200 μL |
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| HUWE1-PHF8-20-GRGR | 20 (40 μL) | 200 μL |
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| HUWE1-PHF8-20-GRAQ | 20 (40 μL) | 200 μL |
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| HUWE1-PHF8-20-AQRE | 20 (40 μL) | 200 μL |
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| HUWE1-PHF8-20-AQOR | 20 (40 μL) | 200 μL |
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| HUWE1-PHF8-20-AQGO | 20 (40 μL) | 200 μL |
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| HUWE1-PHF8-20-AQGR | 20 (40 μL) | 200 μL |
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| HUWE1-PHF8-20-AQAQ | 20 (40 μL) | 200 μL |
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HUWE1 Gene Summary
This gene encodes a protein containing a C-terminal HECT (E6AP type E3 ubiquitin protein ligase) domain that functions as an E3 ubiquitin ligase. The encoded protein is required for the ubiquitination and subsequent degradation of the anti-apoptotic protein Mcl1 (myeloid cell leukemia sequence 1 (BCL2-related)). This protein also ubiquitinates the p53 tumor suppressor, core histones, and DNA polymerase beta. Mutations in this gene are associated with Turner type X-linked syndromic cognitive disability. [provided by RefSeq, Aug 2013]
Gene Name: HECT, UBA And WWE Domain Containing 1, E3 Ubiquitin Protein Ligase
Chromosome: CHRX: 53559062 -53713673
Locus: Xp11.22
PHF8 Gene Summary
The protein encoded by this gene is a histone lysine demethylase that preferentially acts on histones in the monomethyl or dimethyl states. The encoded protein requires Fe(2+) ion, 2-oxoglutarate, and oxygen for its catalytic activity. The protein has an N-terminal PHD finger and a central Jumonji C domain. This gene is thought to function as a transcription activator. Defects in this gene are a cause of syndromic X-linked Siderius type intellectual disability (MRXSSD) and over-expression of this gene is associated with several forms of cancer. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2017]
Gene Name: PHD Finger Protein 8
Chromosome: CHRX: 53963112 -54071569
Locus: Xp11.22
Gene Diseases
The HUWE1 PHF8 Fusion has been associated with the following diseases:
| Disease Name |
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| Uterine Corpus Endometrial Carcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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