HUWE1-CLCN5 Fusion FISH Probe
The HUWE1-CLCN5 Fusion FISH Probe is used to confirm a fusion of the HUWE1 and CLCN5 genes. The fusion of the HUWE1 and CLCN5 genes has been associated with Ovarian Serous Cystadenocarcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| HUWE1-CLCN5-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| HUWE1-CLCN5-20-RERE | 20 (40 μL) | 200 μL |
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| HUWE1-CLCN5-20-REOR | 20 (40 μL) | 200 μL |
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| HUWE1-CLCN5-20-REGO | 20 (40 μL) | 200 μL |
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| HUWE1-CLCN5-20-REGR | 20 (40 μL) | 200 μL |
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| HUWE1-CLCN5-20-REAQ | 20 (40 μL) | 200 μL |
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| HUWE1-CLCN5-20-ORRE | 20 (40 μL) | 200 μL |
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| HUWE1-CLCN5-20-OROR | 20 (40 μL) | 200 μL |
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| HUWE1-CLCN5-20-ORGO | 20 (40 μL) | 200 μL |
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| HUWE1-CLCN5-20-ORAQ | 20 (40 μL) | 200 μL |
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| HUWE1-CLCN5-20-GORE | 20 (40 μL) | 200 μL |
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| HUWE1-CLCN5-20-GOOR | 20 (40 μL) | 200 μL |
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| HUWE1-CLCN5-20-GOGO | 20 (40 μL) | 200 μL |
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| HUWE1-CLCN5-20-GOGR | 20 (40 μL) | 200 μL |
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| HUWE1-CLCN5-20-GOAQ | 20 (40 μL) | 200 μL |
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| HUWE1-CLCN5-20-GRRE | 20 (40 μL) | 200 μL |
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| HUWE1-CLCN5-20-GROR | 20 (40 μL) | 200 μL |
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| HUWE1-CLCN5-20-GRGO | 20 (40 μL) | 200 μL |
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| HUWE1-CLCN5-20-GRGR | 20 (40 μL) | 200 μL |
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| HUWE1-CLCN5-20-GRAQ | 20 (40 μL) | 200 μL |
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| HUWE1-CLCN5-20-AQRE | 20 (40 μL) | 200 μL |
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| HUWE1-CLCN5-20-AQOR | 20 (40 μL) | 200 μL |
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| HUWE1-CLCN5-20-AQGO | 20 (40 μL) | 200 μL |
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| HUWE1-CLCN5-20-AQGR | 20 (40 μL) | 200 μL |
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| HUWE1-CLCN5-20-AQAQ | 20 (40 μL) | 200 μL |
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CLCN5 Gene Summary
This gene encodes a member of the ClC family of chloride ion channels and ion transporters. The encoded protein is primarily localized to endosomal membranes and may function to facilitate albumin uptake by the renal proximal tubule. Mutations in this gene have been found in Dent disease and renal tubular disorders complicated by nephrolithiasis. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Jan 2013]
Gene Name: Chloride Voltage-gated Channel 5
Chromosome: CHRX: 49687224 -49863892
Locus: Xp11.23
HUWE1 Gene Summary
This gene encodes a protein containing a C-terminal HECT (E6AP type E3 ubiquitin protein ligase) domain that functions as an E3 ubiquitin ligase. The encoded protein is required for the ubiquitination and subsequent degradation of the anti-apoptotic protein Mcl1 (myeloid cell leukemia sequence 1 (BCL2-related)). This protein also ubiquitinates the p53 tumor suppressor, core histones, and DNA polymerase beta. Mutations in this gene are associated with Turner type X-linked syndromic cognitive disability. [provided by RefSeq, Aug 2013]
Gene Name: HECT, UBA And WWE Domain Containing 1, E3 Ubiquitin Protein Ligase
Chromosome: CHRX: 53559062 -53713673
Locus: Xp11.22
Gene Diseases
The HUWE1 CLCN5 Fusion has been associated with the following diseases:
| Disease Name |
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| Ovarian Serous Cystadenocarcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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