HUWE1-BICD1 Fusion FISH Probe
The HUWE1-BICD1 Fusion FISH Probe is used to confirm a fusion of the HUWE1 and BICD1 genes. The fusion of the HUWE1 and BICD1 genes has been associated with Bladder Urothelial Carcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| HUWE1-BICD1-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| HUWE1-BICD1-20-RERE | 20 (40 μL) | 200 μL |
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| HUWE1-BICD1-20-REOR | 20 (40 μL) | 200 μL |
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| HUWE1-BICD1-20-REGO | 20 (40 μL) | 200 μL |
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| HUWE1-BICD1-20-REGR | 20 (40 μL) | 200 μL |
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| HUWE1-BICD1-20-REAQ | 20 (40 μL) | 200 μL |
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| HUWE1-BICD1-20-ORRE | 20 (40 μL) | 200 μL |
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| HUWE1-BICD1-20-OROR | 20 (40 μL) | 200 μL |
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| HUWE1-BICD1-20-ORGO | 20 (40 μL) | 200 μL |
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| HUWE1-BICD1-20-ORAQ | 20 (40 μL) | 200 μL |
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| HUWE1-BICD1-20-GORE | 20 (40 μL) | 200 μL |
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| HUWE1-BICD1-20-GOOR | 20 (40 μL) | 200 μL |
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| HUWE1-BICD1-20-GOGO | 20 (40 μL) | 200 μL |
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| HUWE1-BICD1-20-GOGR | 20 (40 μL) | 200 μL |
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| HUWE1-BICD1-20-GOAQ | 20 (40 μL) | 200 μL |
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| HUWE1-BICD1-20-GRRE | 20 (40 μL) | 200 μL |
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| HUWE1-BICD1-20-GROR | 20 (40 μL) | 200 μL |
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| HUWE1-BICD1-20-GRGO | 20 (40 μL) | 200 μL |
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| HUWE1-BICD1-20-GRGR | 20 (40 μL) | 200 μL |
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| HUWE1-BICD1-20-GRAQ | 20 (40 μL) | 200 μL |
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| HUWE1-BICD1-20-AQRE | 20 (40 μL) | 200 μL |
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| HUWE1-BICD1-20-AQOR | 20 (40 μL) | 200 μL |
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| HUWE1-BICD1-20-AQGO | 20 (40 μL) | 200 μL |
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| HUWE1-BICD1-20-AQGR | 20 (40 μL) | 200 μL |
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| HUWE1-BICD1-20-AQAQ | 20 (40 μL) | 200 μL |
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BICD1 Gene Summary
This gene encodes an adaptor protein that belongs to the bicaudal D family of dynein cargo adaptors. The encoded protein acts as an intracellular cargo transport cofactor that regulates the microtubule-based loading of cargo onto the dynein motor complex. It also controls dynein motor activity and coordination. It has a domain architecture consisting of coiled-coil domains at the N- and C-termini that are highly conserved in other family members. Naturally occurring mutations in this gene are associated with short telomere length and emphysema. [provided by RefSeq, Aug 2017]
Gene Name: BICD Cargo Adaptor 1
Chromosome: CHR12: 32260184 -32531141
Locus: 12p11.21
HUWE1 Gene Summary
This gene encodes a protein containing a C-terminal HECT (E6AP type E3 ubiquitin protein ligase) domain that functions as an E3 ubiquitin ligase. The encoded protein is required for the ubiquitination and subsequent degradation of the anti-apoptotic protein Mcl1 (myeloid cell leukemia sequence 1 (BCL2-related)). This protein also ubiquitinates the p53 tumor suppressor, core histones, and DNA polymerase beta. Mutations in this gene are associated with Turner type X-linked syndromic cognitive disability. [provided by RefSeq, Aug 2013]
Gene Name: HECT, UBA And WWE Domain Containing 1, E3 Ubiquitin Protein Ligase
Chromosome: CHRX: 53559062 -53713673
Locus: Xp11.22
Gene Diseases
The HUWE1 BICD1 Fusion has been associated with the following diseases:
| Disease Name |
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| Bladder Urothelial Carcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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