HTRA1-C7 Fusion FISH Probe
The HTRA1-C7 Fusion FISH Probe is used to confirm a fusion of the HTRA1 and C7 genes. The fusion of the HTRA1 and C7 genes has been associated with Kidney Renal Papillary Cell Carcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| HTRA1-C7-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| HTRA1-C7-20-RERE | 20 (40 μL) | 200 μL |
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| HTRA1-C7-20-REOR | 20 (40 μL) | 200 μL |
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| HTRA1-C7-20-REGO | 20 (40 μL) | 200 μL |
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| HTRA1-C7-20-REGR | 20 (40 μL) | 200 μL |
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| HTRA1-C7-20-REAQ | 20 (40 μL) | 200 μL |
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| HTRA1-C7-20-ORRE | 20 (40 μL) | 200 μL |
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| HTRA1-C7-20-OROR | 20 (40 μL) | 200 μL |
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| HTRA1-C7-20-ORGO | 20 (40 μL) | 200 μL |
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| HTRA1-C7-20-ORAQ | 20 (40 μL) | 200 μL |
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| HTRA1-C7-20-GORE | 20 (40 μL) | 200 μL |
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| HTRA1-C7-20-GOOR | 20 (40 μL) | 200 μL |
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| HTRA1-C7-20-GOGO | 20 (40 μL) | 200 μL |
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| HTRA1-C7-20-GOGR | 20 (40 μL) | 200 μL |
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| HTRA1-C7-20-GOAQ | 20 (40 μL) | 200 μL |
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| HTRA1-C7-20-GRRE | 20 (40 μL) | 200 μL |
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| HTRA1-C7-20-GROR | 20 (40 μL) | 200 μL |
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| HTRA1-C7-20-GRGO | 20 (40 μL) | 200 μL |
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| HTRA1-C7-20-GRGR | 20 (40 μL) | 200 μL |
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| HTRA1-C7-20-GRAQ | 20 (40 μL) | 200 μL |
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| HTRA1-C7-20-AQRE | 20 (40 μL) | 200 μL |
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| HTRA1-C7-20-AQOR | 20 (40 μL) | 200 μL |
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| HTRA1-C7-20-AQGO | 20 (40 μL) | 200 μL |
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| HTRA1-C7-20-AQGR | 20 (40 μL) | 200 μL |
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| HTRA1-C7-20-AQAQ | 20 (40 μL) | 200 μL |
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C7 Gene Summary
This gene encodes a serum glycoprotein that forms a membrane attack complex together with complement components C5b, C6, C8, and C9 as part of the terminal complement pathway of the innate immune system. The protein encoded by this gene contains a cholesterol-dependent cytolysin/membrane attack complex/perforin-like (CDC/MACPF) domain and belongs to a large family of structurally related molecules that form pores involved in host immunity and bacterial pathogenesis. This protein initiates membrane attack complex formation by binding the C5b-C6 subcomplex and inserts into the phospholipid bilayer, serving as a membrane anchor. Mutations in this gene are associated with a rare disorder called C7 deficiency. [provided by RefSeq, Nov 2016]
Gene Name: Complement C7
Chromosome: CHR5: 40909598 -40983042
Locus: 5p13.1
HTRA1 Gene Summary
This gene encodes a member of the trypsin family of serine proteases. This protein is a secreted enzyme that is proposed to regulate the availability of insulin-like growth factors (IGFs) by cleaving IGF-binding proteins. It has also been suggested to be a regulator of cell growth. Variations in the promoter region of this gene are the cause of susceptibility to age-related macular degeneration type 7. [provided by RefSeq, Jul 2008]
Gene Name: HtrA Serine Peptidase 1
Chromosome: CHR10: 124221040 -124274424
Locus: 10q26.13
Gene Diseases
The HTRA1 C7 Fusion has been associated with the following diseases:
| Disease Name |
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| Kidney Renal Papillary Cell Carcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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