HSPH1-DDX27 Fusion FISH Probe
The HSPH1-DDX27 Fusion FISH Probe is used to confirm a fusion of the HSPH1 and DDX27 genes. The fusion of the HSPH1 and DDX27 genes has been associated with Brain Lower Grade Glioma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| HSPH1-DDX27-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| HSPH1-DDX27-20-RERE | 20 (40 μL) | 200 μL |
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| HSPH1-DDX27-20-REOR | 20 (40 μL) | 200 μL |
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| HSPH1-DDX27-20-REGO | 20 (40 μL) | 200 μL |
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| HSPH1-DDX27-20-REGR | 20 (40 μL) | 200 μL |
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| HSPH1-DDX27-20-REAQ | 20 (40 μL) | 200 μL |
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| HSPH1-DDX27-20-ORRE | 20 (40 μL) | 200 μL |
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| HSPH1-DDX27-20-OROR | 20 (40 μL) | 200 μL |
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| HSPH1-DDX27-20-ORGO | 20 (40 μL) | 200 μL |
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| HSPH1-DDX27-20-ORAQ | 20 (40 μL) | 200 μL |
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| HSPH1-DDX27-20-GORE | 20 (40 μL) | 200 μL |
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| HSPH1-DDX27-20-GOOR | 20 (40 μL) | 200 μL |
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| HSPH1-DDX27-20-GOGO | 20 (40 μL) | 200 μL |
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| HSPH1-DDX27-20-GOGR | 20 (40 μL) | 200 μL |
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| HSPH1-DDX27-20-GOAQ | 20 (40 μL) | 200 μL |
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| HSPH1-DDX27-20-GRRE | 20 (40 μL) | 200 μL |
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| HSPH1-DDX27-20-GROR | 20 (40 μL) | 200 μL |
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| HSPH1-DDX27-20-GRGO | 20 (40 μL) | 200 μL |
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| HSPH1-DDX27-20-GRGR | 20 (40 μL) | 200 μL |
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| HSPH1-DDX27-20-GRAQ | 20 (40 μL) | 200 μL |
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| HSPH1-DDX27-20-AQRE | 20 (40 μL) | 200 μL |
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| HSPH1-DDX27-20-AQOR | 20 (40 μL) | 200 μL |
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| HSPH1-DDX27-20-AQGO | 20 (40 μL) | 200 μL |
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| HSPH1-DDX27-20-AQGR | 20 (40 μL) | 200 μL |
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| HSPH1-DDX27-20-AQAQ | 20 (40 μL) | 200 μL |
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HSPH1 Gene Summary
This gene encodes a member of the heat shock protein 70 family of proteins. The encoded protein functions as a nucleotide exchange factor for the molecular chaperone heat shock cognate 71 kDa protein (Hsc70). In addition, this protein plays a distinct but related role as a holdase that inhibits the aggregation of misfolded proteins, including the cystic fibrosis transmembrane conductance regulator (CFTR) protein. Elevated expression of this protein has been observed in numerous human cancers. [provided by RefSeq, Mar 2017]
Gene Name: Heat Shock Protein Family H (Hsp110) Member 1
Chromosome: CHR13: 31710762 -31736117
Locus: 13q12.3
DDX27 Gene Summary
DEAD box proteins, characterized by the conserved motif Asp-Glu-Ala-Asp (DEAD), are putative RNA helicases. They are implicated in a number of cellular processes involving alteration of RNA secondary structure such as translation initiation, nuclear and mitochondrial splicing, and ribosome and spliceosome assembly. Based on their distribution patterns, some members of this family are believed to be involved in embryogenesis, spermatogenesis, and cellular growth and division. This gene encodes a DEAD box protein involved in the processing of 5.8S and 28S ribosomal RNAs. More specifically, the encoded protein localizes to the nucleolus, where it interacts with the PeBoW complex to ensure proper 3' end formation of 47S rRNA. [provided by RefSeq, Jan 2017]
Gene Name: DEAD-box Helicase 27
Chromosome: CHR20: 47835831 -47860614
Locus: 20q13.13
Gene Diseases
The HSPH1 DDX27 Fusion has been associated with the following diseases:
| Disease Name |
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| Brain Lower Grade Glioma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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