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HSPG2-NTNG1 Fusion FISH Probe

The HSPG2-NTNG1 Fusion FISH Probe is used to confirm a fusion of the HSPG2 and NTNG1 genes. The fusion of the HSPG2 and NTNG1 genes has been associated with Lung Adenocarcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.

** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.

Turnaround Time: 7-10 Business Days    Shipping Time: 1-2 Day Expedited Shipping

SKU Test Kits Buffer Dye Color Order Now
HSPG2-NTNG1-20-ORGR  (Standard Design) 20 (40 μL) 200 μL
HSPG2-NTNG1-20-RERE 20 (40 μL) 200 μL
HSPG2-NTNG1-20-REOR 20 (40 μL) 200 μL
HSPG2-NTNG1-20-REGO 20 (40 μL) 200 μL
HSPG2-NTNG1-20-REGR 20 (40 μL) 200 μL
HSPG2-NTNG1-20-REAQ 20 (40 μL) 200 μL
HSPG2-NTNG1-20-ORRE 20 (40 μL) 200 μL
HSPG2-NTNG1-20-OROR 20 (40 μL) 200 μL
HSPG2-NTNG1-20-ORGO 20 (40 μL) 200 μL
HSPG2-NTNG1-20-ORAQ 20 (40 μL) 200 μL
HSPG2-NTNG1-20-GORE 20 (40 μL) 200 μL
HSPG2-NTNG1-20-GOOR 20 (40 μL) 200 μL
HSPG2-NTNG1-20-GOGO 20 (40 μL) 200 μL
HSPG2-NTNG1-20-GOGR 20 (40 μL) 200 μL
HSPG2-NTNG1-20-GOAQ 20 (40 μL) 200 μL
HSPG2-NTNG1-20-GRRE 20 (40 μL) 200 μL
HSPG2-NTNG1-20-GROR 20 (40 μL) 200 μL
HSPG2-NTNG1-20-GRGO 20 (40 μL) 200 μL
HSPG2-NTNG1-20-GRGR 20 (40 μL) 200 μL
HSPG2-NTNG1-20-GRAQ 20 (40 μL) 200 μL
HSPG2-NTNG1-20-AQRE 20 (40 μL) 200 μL
HSPG2-NTNG1-20-AQOR 20 (40 μL) 200 μL
HSPG2-NTNG1-20-AQGO 20 (40 μL) 200 μL
HSPG2-NTNG1-20-AQGR 20 (40 μL) 200 μL
HSPG2-NTNG1-20-AQAQ 20 (40 μL) 200 μL

HSPG2 Gene Summary

This gene encodes the perlecan protein, which consists of a core protein to which three long chains of glycosaminoglycans (heparan sulfate or chondroitin sulfate) are attached. The perlecan protein is a large multidomain proteoglycan that binds to and cross-links many extracellular matrix components and cell-surface molecules. It has been shown that this protein interacts with laminin, prolargin, collagen type IV, FGFBP1, FBLN2, FGF7 and transthyretin, etc., and it plays essential roles in multiple biological activities. Perlecan is a key component of the vascular extracellular matrix, where it helps to maintain the endothelial barrier function. It is a potent inhibitor of smooth muscle cell proliferation and is thus thought to help maintain vascular homeostasis. It can also promote growth factor (e.g., FGF2) activity and thus stimulate endothelial growth and re-generation. It is a major component of basement membranes, where it is involved in the stabilization of other molecules as well as being involved with glomerular permeability to macromolecules and cell adhesion. Mutations in this gene cause Schwartz-Jampel syndrome type 1, Silverman-Handmaker type of dyssegmental dysplasia, and tardive dyskinesia. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, May 2014]

Gene Name: Heparan Sulfate Proteoglycan 2

Chromosome: CHR1: 22148736 -22263750

Locus: 1p36.12

NTNG1 Gene Summary

This gene encodes a preproprotein that is processed into a secreted protein containing eukaroytic growth factor (EGF)-like domains. This protein acts to guide axon growth during neuronal development. Polymorphisms in this gene may be associated with schizophrenia. Alternative splicing results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq, Aug 2015]

Gene Name: Netrin G1

Chromosome: CHR1: 107682628 -108024475

Locus: 1p13.3

Gene Diseases

The HSPG2 NTNG1 Fusion has been associated with the following diseases:

Disease Name
Lung Adenocarcinoma

FISH Probe Protocols

Protocol, Procedure, or Form Name Last Modified Download

Customer Publications

There are currently no FISH related publications for this probe.