HSPG2-NTNG1 Fusion FISH Probe
The HSPG2-NTNG1 Fusion FISH Probe is used to confirm a fusion of the HSPG2 and NTNG1 genes. The fusion of the HSPG2 and NTNG1 genes has been associated with Lung Adenocarcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| HSPG2-NTNG1-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| HSPG2-NTNG1-20-RERE | 20 (40 μL) | 200 μL |
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| HSPG2-NTNG1-20-REOR | 20 (40 μL) | 200 μL |
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| HSPG2-NTNG1-20-REGO | 20 (40 μL) | 200 μL |
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| HSPG2-NTNG1-20-REGR | 20 (40 μL) | 200 μL |
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| HSPG2-NTNG1-20-REAQ | 20 (40 μL) | 200 μL |
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| HSPG2-NTNG1-20-ORRE | 20 (40 μL) | 200 μL |
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| HSPG2-NTNG1-20-OROR | 20 (40 μL) | 200 μL |
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| HSPG2-NTNG1-20-ORGO | 20 (40 μL) | 200 μL |
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| HSPG2-NTNG1-20-ORAQ | 20 (40 μL) | 200 μL |
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| HSPG2-NTNG1-20-GORE | 20 (40 μL) | 200 μL |
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| HSPG2-NTNG1-20-GOOR | 20 (40 μL) | 200 μL |
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| HSPG2-NTNG1-20-GOGO | 20 (40 μL) | 200 μL |
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| HSPG2-NTNG1-20-GOGR | 20 (40 μL) | 200 μL |
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| HSPG2-NTNG1-20-GOAQ | 20 (40 μL) | 200 μL |
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| HSPG2-NTNG1-20-GRRE | 20 (40 μL) | 200 μL |
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| HSPG2-NTNG1-20-GROR | 20 (40 μL) | 200 μL |
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| HSPG2-NTNG1-20-GRGO | 20 (40 μL) | 200 μL |
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| HSPG2-NTNG1-20-GRGR | 20 (40 μL) | 200 μL |
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| HSPG2-NTNG1-20-GRAQ | 20 (40 μL) | 200 μL |
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| HSPG2-NTNG1-20-AQRE | 20 (40 μL) | 200 μL |
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| HSPG2-NTNG1-20-AQOR | 20 (40 μL) | 200 μL |
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| HSPG2-NTNG1-20-AQGO | 20 (40 μL) | 200 μL |
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| HSPG2-NTNG1-20-AQGR | 20 (40 μL) | 200 μL |
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| HSPG2-NTNG1-20-AQAQ | 20 (40 μL) | 200 μL |
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HSPG2 Gene Summary
This gene encodes the perlecan protein, which consists of a core protein to which three long chains of glycosaminoglycans (heparan sulfate or chondroitin sulfate) are attached. The perlecan protein is a large multidomain proteoglycan that binds to and cross-links many extracellular matrix components and cell-surface molecules. It has been shown that this protein interacts with laminin, prolargin, collagen type IV, FGFBP1, FBLN2, FGF7 and transthyretin, etc., and it plays essential roles in multiple biological activities. Perlecan is a key component of the vascular extracellular matrix, where it helps to maintain the endothelial barrier function. It is a potent inhibitor of smooth muscle cell proliferation and is thus thought to help maintain vascular homeostasis. It can also promote growth factor (e.g., FGF2) activity and thus stimulate endothelial growth and re-generation. It is a major component of basement membranes, where it is involved in the stabilization of other molecules as well as being involved with glomerular permeability to macromolecules and cell adhesion. Mutations in this gene cause Schwartz-Jampel syndrome type 1, Silverman-Handmaker type of dyssegmental dysplasia, and tardive dyskinesia. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, May 2014]
Gene Name: Heparan Sulfate Proteoglycan 2
Chromosome: CHR1: 22148736 -22263750
Locus: 1p36.12
NTNG1 Gene Summary
This gene encodes a preproprotein that is processed into a secreted protein containing eukaroytic growth factor (EGF)-like domains. This protein acts to guide axon growth during neuronal development. Polymorphisms in this gene may be associated with schizophrenia. Alternative splicing results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq, Aug 2015]
Gene Name: Netrin G1
Chromosome: CHR1: 107682628 -108024475
Locus: 1p13.3
Gene Diseases
The HSPG2 NTNG1 Fusion has been associated with the following diseases:
| Disease Name |
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| Lung Adenocarcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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