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HSPG2-MATN2 Fusion FISH Probe

The HSPG2-MATN2 Fusion FISH Probe is used to confirm a fusion of the HSPG2 and MATN2 genes. The fusion of the HSPG2 and MATN2 genes has been associated with Uterine Corpus Endometrial Carcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.

** This product is for in vitro and research use only. This product is not intended for diagnostic use.

Turnaround Time: 7-10 Business Days    Shipping Time: 1-2 Day Expedited Shipping

SKU Test Kits Buffer Dye Color Order Now
HSPG2-MATN2-20-ORGR  (Standard Design) 20 (40 μL) 200 μL
HSPG2-MATN2-20-RERE 20 (40 μL) 200 μL
HSPG2-MATN2-20-REOR 20 (40 μL) 200 μL
HSPG2-MATN2-20-REGO 20 (40 μL) 200 μL
HSPG2-MATN2-20-REGR 20 (40 μL) 200 μL
HSPG2-MATN2-20-REAQ 20 (40 μL) 200 μL
HSPG2-MATN2-20-ORRE 20 (40 μL) 200 μL
HSPG2-MATN2-20-OROR 20 (40 μL) 200 μL
HSPG2-MATN2-20-ORGO 20 (40 μL) 200 μL
HSPG2-MATN2-20-ORAQ 20 (40 μL) 200 μL
HSPG2-MATN2-20-GORE 20 (40 μL) 200 μL
HSPG2-MATN2-20-GOOR 20 (40 μL) 200 μL
HSPG2-MATN2-20-GOGO 20 (40 μL) 200 μL
HSPG2-MATN2-20-GOGR 20 (40 μL) 200 μL
HSPG2-MATN2-20-GOAQ 20 (40 μL) 200 μL
HSPG2-MATN2-20-GRRE 20 (40 μL) 200 μL
HSPG2-MATN2-20-GROR 20 (40 μL) 200 μL
HSPG2-MATN2-20-GRGO 20 (40 μL) 200 μL
HSPG2-MATN2-20-GRGR 20 (40 μL) 200 μL
HSPG2-MATN2-20-GRAQ 20 (40 μL) 200 μL
HSPG2-MATN2-20-AQRE 20 (40 μL) 200 μL
HSPG2-MATN2-20-AQOR 20 (40 μL) 200 μL
HSPG2-MATN2-20-AQGO 20 (40 μL) 200 μL
HSPG2-MATN2-20-AQGR 20 (40 μL) 200 μL
HSPG2-MATN2-20-AQAQ 20 (40 μL) 200 μL

HSPG2 Gene Summary

This gene encodes the perlecan protein, which consists of a core protein to which three long chains of glycosaminoglycans (heparan sulfate or chondroitin sulfate) are attached. The perlecan protein is a large multidomain proteoglycan that binds to and cross-links many extracellular matrix components and cell-surface molecules. It has been shown that this protein interacts with laminin, prolargin, collagen type IV, FGFBP1, FBLN2, FGF7 and transthyretin, etc., and it plays essential roles in multiple biological activities. Perlecan is a key component of the vascular extracellular matrix, where it helps to maintain the endothelial barrier function. It is a potent inhibitor of smooth muscle cell proliferation and is thus thought to help maintain vascular homeostasis. It can also promote growth factor (e.g., FGF2) activity and thus stimulate endothelial growth and re-generation. It is a major component of basement membranes, where it is involved in the stabilization of other molecules as well as being involved with glomerular permeability to macromolecules and cell adhesion. Mutations in this gene cause Schwartz-Jampel syndrome type 1, Silverman-Handmaker type of dyssegmental dysplasia, and tardive dyskinesia. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, May 2014]

Gene Name: Heparan Sulfate Proteoglycan 2

Chromosome: CHR1: 22148736 -22263750

Locus: 1p36.12

MATN2 Gene Summary

This gene encodes a member of the von Willebrand factor A domain containing protein family. This family of proteins is thought to be involved in the formation of filamentous networks in the extracellular matrices of various tissues. This protein contains five von Willebrand factor A domains. The specific function of this gene has not yet been determined. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

Gene Name: Matrilin 2

Chromosome: CHR8: 98881310 -99048946

Locus: 8q22.1-q22.2

Gene Diseases

The HSPG2 MATN2 Fusion has been associated with the following diseases:

Disease Name
Uterine Corpus Endometrial Carcinoma

FISH Probe Protocols

Protocol, Procedure, or Form Name Last Modified Download

Customer Publications

There are currently no FISH related publications for this probe.