HSPB1-TTN Fusion FISH Probe
The HSPB1-TTN Fusion FISH Probe is used to confirm a fusion of the HSPB1 and TTN genes. The fusion of the HSPB1 and TTN genes has been associated with Head And Neck Squamous Cell Carcinoma . These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| HSPB1-TTN-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| HSPB1-TTN-20-RERE | 20 (40 μL) | 200 μL |
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| HSPB1-TTN-20-REOR | 20 (40 μL) | 200 μL |
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| HSPB1-TTN-20-REGO | 20 (40 μL) | 200 μL |
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| HSPB1-TTN-20-REGR | 20 (40 μL) | 200 μL |
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| HSPB1-TTN-20-REAQ | 20 (40 μL) | 200 μL |
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| HSPB1-TTN-20-ORRE | 20 (40 μL) | 200 μL |
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| HSPB1-TTN-20-OROR | 20 (40 μL) | 200 μL |
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| HSPB1-TTN-20-ORGO | 20 (40 μL) | 200 μL |
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| HSPB1-TTN-20-ORAQ | 20 (40 μL) | 200 μL |
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| HSPB1-TTN-20-GORE | 20 (40 μL) | 200 μL |
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| HSPB1-TTN-20-GOOR | 20 (40 μL) | 200 μL |
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| HSPB1-TTN-20-GOGO | 20 (40 μL) | 200 μL |
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| HSPB1-TTN-20-GOGR | 20 (40 μL) | 200 μL |
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| HSPB1-TTN-20-GOAQ | 20 (40 μL) | 200 μL |
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| HSPB1-TTN-20-GRRE | 20 (40 μL) | 200 μL |
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| HSPB1-TTN-20-GROR | 20 (40 μL) | 200 μL |
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| HSPB1-TTN-20-GRGO | 20 (40 μL) | 200 μL |
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| HSPB1-TTN-20-GRGR | 20 (40 μL) | 200 μL |
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| HSPB1-TTN-20-GRAQ | 20 (40 μL) | 200 μL |
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| HSPB1-TTN-20-AQRE | 20 (40 μL) | 200 μL |
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| HSPB1-TTN-20-AQOR | 20 (40 μL) | 200 μL |
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| HSPB1-TTN-20-AQGO | 20 (40 μL) | 200 μL |
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| HSPB1-TTN-20-AQGR | 20 (40 μL) | 200 μL |
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| HSPB1-TTN-20-AQAQ | 20 (40 μL) | 200 μL |
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HSPB1 Gene Summary
This gene encodes a member of the small heat shock protein (HSP20) family of proteins. In response to environmental stress, the encoded protein translocates from the cytoplasm to the nucleus and functions as a molecular chaperone that promotes the correct folding of other proteins. This protein plays an important role in the differentiation of a wide variety of cell types. Expression of this gene is correlated with poor clinical outcome in multiple human cancers, and the encoded protein may promote cancer cell proliferation and metastasis, while protecting cancer cells from apoptosis. Mutations in this gene have been identified in human patients with Charcot-Marie-Tooth disease and distal hereditary motor neuropathy. [provided by RefSeq, Aug 2017]
Gene Name: Heat Shock Protein Family B (small) Member 1
Chromosome: CHR7: 75931874 -75933614
Locus: 7q11.23
TTN Gene Summary
This gene encodes a large abundant protein of striated muscle. The product of this gene is divided into two regions, a N-terminal I-band and a C-terminal A-band. The I-band, which is the elastic part of the molecule, contains two regions of tandem immunoglobulin domains on either side of a PEVK region that is rich in proline, glutamate, valine and lysine. The A-band, which is thought to act as a protein-ruler, contains a mixture of immunoglobulin and fibronectin repeats, and possesses kinase activity. An N-terminal Z-disc region and a C-terminal M-line region bind to the Z-line and M-line of the sarcomere, respectively, so that a single titin molecule spans half the length of a sarcomere. Titin also contains binding sites for muscle associated proteins so it serves as an adhesion template for the assembly of contractile machinery in muscle cells. It has also been identified as a structural protein for chromosomes. Alternative splicing of this gene results in multiple transcript variants. Considerable variability exists in the I-band, the M-line and the Z-disc regions of titin. Variability in the I-band region contributes to the differences in elasticity of different titin isoforms and, therefore, to the differences in elasticity of different muscle types. Mutations in this gene are associated with familial hypertrophic cardiomyopathy 9, and autoantibodies to titin are produced in patients with the autoimmune disease scleroderma. [provided by RefSeq, Feb 2012]
Gene Name: Titin
Chromosome: CHR2: 179390717 -179672150
Locus: 2q31.2
Gene Diseases
The HSPB1 TTN Fusion has been associated with the following diseases:
| Disease Name |
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| Head And Neck Squamous Cell Carcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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