HSPB1-STAT6 Fusion FISH Probe
The HSPB1-STAT6 Fusion FISH Probe is used to confirm a fusion of the HSPB1 and STAT6 genes. The fusion of the HSPB1 and STAT6 genes has been associated with Cervical Squamous Cell Carcinoma And Endocervical Adenocarcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| HSPB1-STAT6-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| HSPB1-STAT6-20-RERE | 20 (40 μL) | 200 μL |
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| HSPB1-STAT6-20-REOR | 20 (40 μL) | 200 μL |
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| HSPB1-STAT6-20-REGO | 20 (40 μL) | 200 μL |
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| HSPB1-STAT6-20-REGR | 20 (40 μL) | 200 μL |
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| HSPB1-STAT6-20-REAQ | 20 (40 μL) | 200 μL |
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| HSPB1-STAT6-20-ORRE | 20 (40 μL) | 200 μL |
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| HSPB1-STAT6-20-OROR | 20 (40 μL) | 200 μL |
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| HSPB1-STAT6-20-ORGO | 20 (40 μL) | 200 μL |
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| HSPB1-STAT6-20-ORAQ | 20 (40 μL) | 200 μL |
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| HSPB1-STAT6-20-GORE | 20 (40 μL) | 200 μL |
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| HSPB1-STAT6-20-GOOR | 20 (40 μL) | 200 μL |
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| HSPB1-STAT6-20-GOGO | 20 (40 μL) | 200 μL |
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| HSPB1-STAT6-20-GOGR | 20 (40 μL) | 200 μL |
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| HSPB1-STAT6-20-GOAQ | 20 (40 μL) | 200 μL |
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| HSPB1-STAT6-20-GRRE | 20 (40 μL) | 200 μL |
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| HSPB1-STAT6-20-GROR | 20 (40 μL) | 200 μL |
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| HSPB1-STAT6-20-GRGO | 20 (40 μL) | 200 μL |
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| HSPB1-STAT6-20-GRGR | 20 (40 μL) | 200 μL |
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| HSPB1-STAT6-20-GRAQ | 20 (40 μL) | 200 μL |
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| HSPB1-STAT6-20-AQRE | 20 (40 μL) | 200 μL |
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| HSPB1-STAT6-20-AQOR | 20 (40 μL) | 200 μL |
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| HSPB1-STAT6-20-AQGO | 20 (40 μL) | 200 μL |
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| HSPB1-STAT6-20-AQGR | 20 (40 μL) | 200 μL |
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| HSPB1-STAT6-20-AQAQ | 20 (40 μL) | 200 μL |
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HSPB1 Gene Summary
This gene encodes a member of the small heat shock protein (HSP20) family of proteins. In response to environmental stress, the encoded protein translocates from the cytoplasm to the nucleus and functions as a molecular chaperone that promotes the correct folding of other proteins. This protein plays an important role in the differentiation of a wide variety of cell types. Expression of this gene is correlated with poor clinical outcome in multiple human cancers, and the encoded protein may promote cancer cell proliferation and metastasis, while protecting cancer cells from apoptosis. Mutations in this gene have been identified in human patients with Charcot-Marie-Tooth disease and distal hereditary motor neuropathy. [provided by RefSeq, Aug 2017]
Gene Name: Heat Shock Protein Family B (small) Member 1
Chromosome: CHR7: 75931874 -75933614
Locus: 7q11.23
STAT6 Gene Summary
The protein encoded by this gene is a member of the STAT family of transcription factors. In response to cytokines and growth factors, STAT family members are phosphorylated by the receptor associated kinases, and then form homo- or heterodimers that translocate to the cell nucleus where they act as transcription activators. This protein plays a central role in exerting IL4 mediated biological responses. It is found to induce the expression of BCL2L1/BCL-X(L), which is responsible for the anti-apoptotic activity of IL4. Knockout studies in mice suggested the roles of this gene in differentiation of T helper 2 (Th2) cells, expression of cell surface markers, and class switch of immunoglobulins. Alternative splicing results in multiple transcript variants.[provided by RefSeq, May 2010]
Gene Name: Signal Transducer And Activator Of Transcription 6
Chromosome: CHR12: 57489186 -57505196
Locus: 12q13.3
Gene Diseases
The HSPB1 STAT6 Fusion has been associated with the following diseases:
| Disease Name |
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| Cervical Squamous Cell Carcinoma And Endocervical Adenocarcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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