HSPB1-SF3B2 Fusion FISH Probe
The HSPB1-SF3B2 Fusion FISH Probe is used to confirm a fusion of the HSPB1 and SF3B2 genes. The fusion of the HSPB1 and SF3B2 genes has been associated with Lung Squamous Cell Carcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| HSPB1-SF3B2-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| HSPB1-SF3B2-20-RERE | 20 (40 μL) | 200 μL |
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| HSPB1-SF3B2-20-REOR | 20 (40 μL) | 200 μL |
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| HSPB1-SF3B2-20-REGO | 20 (40 μL) | 200 μL |
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| HSPB1-SF3B2-20-REGR | 20 (40 μL) | 200 μL |
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| HSPB1-SF3B2-20-REAQ | 20 (40 μL) | 200 μL |
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| HSPB1-SF3B2-20-ORRE | 20 (40 μL) | 200 μL |
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| HSPB1-SF3B2-20-OROR | 20 (40 μL) | 200 μL |
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| HSPB1-SF3B2-20-ORGO | 20 (40 μL) | 200 μL |
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| HSPB1-SF3B2-20-ORAQ | 20 (40 μL) | 200 μL |
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| HSPB1-SF3B2-20-GORE | 20 (40 μL) | 200 μL |
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| HSPB1-SF3B2-20-GOOR | 20 (40 μL) | 200 μL |
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| HSPB1-SF3B2-20-GOGO | 20 (40 μL) | 200 μL |
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| HSPB1-SF3B2-20-GOGR | 20 (40 μL) | 200 μL |
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| HSPB1-SF3B2-20-GOAQ | 20 (40 μL) | 200 μL |
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| HSPB1-SF3B2-20-GRRE | 20 (40 μL) | 200 μL |
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| HSPB1-SF3B2-20-GROR | 20 (40 μL) | 200 μL |
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| HSPB1-SF3B2-20-GRGO | 20 (40 μL) | 200 μL |
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| HSPB1-SF3B2-20-GRGR | 20 (40 μL) | 200 μL |
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| HSPB1-SF3B2-20-GRAQ | 20 (40 μL) | 200 μL |
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| HSPB1-SF3B2-20-AQRE | 20 (40 μL) | 200 μL |
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| HSPB1-SF3B2-20-AQOR | 20 (40 μL) | 200 μL |
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| HSPB1-SF3B2-20-AQGO | 20 (40 μL) | 200 μL |
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| HSPB1-SF3B2-20-AQGR | 20 (40 μL) | 200 μL |
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| HSPB1-SF3B2-20-AQAQ | 20 (40 μL) | 200 μL |
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HSPB1 Gene Summary
This gene encodes a member of the small heat shock protein (HSP20) family of proteins. In response to environmental stress, the encoded protein translocates from the cytoplasm to the nucleus and functions as a molecular chaperone that promotes the correct folding of other proteins. This protein plays an important role in the differentiation of a wide variety of cell types. Expression of this gene is correlated with poor clinical outcome in multiple human cancers, and the encoded protein may promote cancer cell proliferation and metastasis, while protecting cancer cells from apoptosis. Mutations in this gene have been identified in human patients with Charcot-Marie-Tooth disease and distal hereditary motor neuropathy. [provided by RefSeq, Aug 2017]
Gene Name: Heat Shock Protein Family B (small) Member 1
Chromosome: CHR7: 75931874 -75933614
Locus: 7q11.23
SF3B2 Gene Summary
This gene encodes subunit 2 of the splicing factor 3b protein complex. Splicing factor 3b, together with splicing factor 3a and a 12S RNA unit, forms the U2 small nuclear ribonucleoproteins complex (U2 snRNP). The splicing factor 3b/3a complex binds pre-mRNA upstream of the intron's branch site in a sequence-independent manner and may anchor the U2 snRNP to the pre-mRNA. Splicing factor 3b is also a component of the minor U12-type spliceosome. Subunit 2 associates with pre-mRNA upstream of the branch site at the anchoring site. Subunit 2 also interacts directly with subunit 4 of the splicing factor 3b complex. Subunit 2 is a highly hydrophilic protein with a proline-rich N-terminus and a glutamate-rich stretch in the C-terminus. [provided by RefSeq, Jul 2008]
Gene Name: Splicing Factor 3b Subunit 2
Chromosome: CHR11: 65819815 -65836382
Locus: 11q13.1
Gene Diseases
The HSPB1 SF3B2 Fusion has been associated with the following diseases:
| Disease Name |
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| Lung Squamous Cell Carcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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