HSPB1-PLAT Fusion FISH Probe
The HSPB1-PLAT Fusion FISH Probe is used to confirm a fusion of the HSPB1 and PLAT genes. The fusion of the HSPB1 and PLAT genes has been associated with Cervical Squamous Cell Carcinoma And Endocervical Adenocarcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| HSPB1-PLAT-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| HSPB1-PLAT-20-RERE | 20 (40 μL) | 200 μL |
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| HSPB1-PLAT-20-REOR | 20 (40 μL) | 200 μL |
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| HSPB1-PLAT-20-REGO | 20 (40 μL) | 200 μL |
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| HSPB1-PLAT-20-REGR | 20 (40 μL) | 200 μL |
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| HSPB1-PLAT-20-REAQ | 20 (40 μL) | 200 μL |
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| HSPB1-PLAT-20-ORRE | 20 (40 μL) | 200 μL |
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| HSPB1-PLAT-20-OROR | 20 (40 μL) | 200 μL |
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| HSPB1-PLAT-20-ORGO | 20 (40 μL) | 200 μL |
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| HSPB1-PLAT-20-ORAQ | 20 (40 μL) | 200 μL |
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| HSPB1-PLAT-20-GORE | 20 (40 μL) | 200 μL |
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| HSPB1-PLAT-20-GOOR | 20 (40 μL) | 200 μL |
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| HSPB1-PLAT-20-GOGO | 20 (40 μL) | 200 μL |
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| HSPB1-PLAT-20-GOGR | 20 (40 μL) | 200 μL |
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| HSPB1-PLAT-20-GOAQ | 20 (40 μL) | 200 μL |
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| HSPB1-PLAT-20-GRRE | 20 (40 μL) | 200 μL |
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| HSPB1-PLAT-20-GROR | 20 (40 μL) | 200 μL |
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| HSPB1-PLAT-20-GRGO | 20 (40 μL) | 200 μL |
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| HSPB1-PLAT-20-GRGR | 20 (40 μL) | 200 μL |
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| HSPB1-PLAT-20-GRAQ | 20 (40 μL) | 200 μL |
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| HSPB1-PLAT-20-AQRE | 20 (40 μL) | 200 μL |
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| HSPB1-PLAT-20-AQOR | 20 (40 μL) | 200 μL |
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| HSPB1-PLAT-20-AQGO | 20 (40 μL) | 200 μL |
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| HSPB1-PLAT-20-AQGR | 20 (40 μL) | 200 μL |
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| HSPB1-PLAT-20-AQAQ | 20 (40 μL) | 200 μL |
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HSPB1 Gene Summary
This gene encodes a member of the small heat shock protein (HSP20) family of proteins. In response to environmental stress, the encoded protein translocates from the cytoplasm to the nucleus and functions as a molecular chaperone that promotes the correct folding of other proteins. This protein plays an important role in the differentiation of a wide variety of cell types. Expression of this gene is correlated with poor clinical outcome in multiple human cancers, and the encoded protein may promote cancer cell proliferation and metastasis, while protecting cancer cells from apoptosis. Mutations in this gene have been identified in human patients with Charcot-Marie-Tooth disease and distal hereditary motor neuropathy. [provided by RefSeq, Aug 2017]
Gene Name: Heat Shock Protein Family B (small) Member 1
Chromosome: CHR7: 75931874 -75933614
Locus: 7q11.23
PLAT Gene Summary
This gene encodes tissue-type plasminogen activator, a secreted serine protease that converts the proenzyme plasminogen to plasmin, a fibrinolytic enzyme. The encoded preproprotein is proteolytically processed by plasmin or trypsin to generate heavy and light chains. These chains associate via disulfide linkages to form the heterodimeric enzyme. This enzyme plays a role in cell migration and tissue remodeling. Increased enzymatic activity causes hyperfibrinolysis, which manifests as excessive bleeding, while decreased activity leads to hypofibrinolysis, which can result in thrombosis or embolism. Alternative splicing of this gene results in multiple transcript variants, at least one of which encodes an isoform that is proteolytically processed. [provided by RefSeq, Jan 2016]
Gene Name: Plasminogen Activator, Tissue Type
Chromosome: CHR8: 42032235 -42065194
Locus: 8p11.21
Gene Diseases
The HSPB1 PLAT Fusion has been associated with the following diseases:
| Disease Name |
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| Cervical Squamous Cell Carcinoma And Endocervical Adenocarcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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