HSPB1-DDX27 Fusion FISH Probe
The HSPB1-DDX27 Fusion FISH Probe is used to confirm a fusion of the HSPB1 and DDX27 genes. The fusion of the HSPB1 and DDX27 genes has been associated with Cervical Squamous Cell Carcinoma And Endocervical Adenocarcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| HSPB1-DDX27-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| HSPB1-DDX27-20-RERE | 20 (40 μL) | 200 μL |
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| HSPB1-DDX27-20-REOR | 20 (40 μL) | 200 μL |
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| HSPB1-DDX27-20-REGO | 20 (40 μL) | 200 μL |
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| HSPB1-DDX27-20-REGR | 20 (40 μL) | 200 μL |
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| HSPB1-DDX27-20-REAQ | 20 (40 μL) | 200 μL |
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| HSPB1-DDX27-20-ORRE | 20 (40 μL) | 200 μL |
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| HSPB1-DDX27-20-OROR | 20 (40 μL) | 200 μL |
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| HSPB1-DDX27-20-ORGO | 20 (40 μL) | 200 μL |
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| HSPB1-DDX27-20-ORAQ | 20 (40 μL) | 200 μL |
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| HSPB1-DDX27-20-GORE | 20 (40 μL) | 200 μL |
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| HSPB1-DDX27-20-GOOR | 20 (40 μL) | 200 μL |
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| HSPB1-DDX27-20-GOGO | 20 (40 μL) | 200 μL |
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| HSPB1-DDX27-20-GOGR | 20 (40 μL) | 200 μL |
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| HSPB1-DDX27-20-GOAQ | 20 (40 μL) | 200 μL |
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| HSPB1-DDX27-20-GRRE | 20 (40 μL) | 200 μL |
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| HSPB1-DDX27-20-GROR | 20 (40 μL) | 200 μL |
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| HSPB1-DDX27-20-GRGO | 20 (40 μL) | 200 μL |
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| HSPB1-DDX27-20-GRGR | 20 (40 μL) | 200 μL |
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| HSPB1-DDX27-20-GRAQ | 20 (40 μL) | 200 μL |
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| HSPB1-DDX27-20-AQRE | 20 (40 μL) | 200 μL |
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| HSPB1-DDX27-20-AQOR | 20 (40 μL) | 200 μL |
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| HSPB1-DDX27-20-AQGO | 20 (40 μL) | 200 μL |
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| HSPB1-DDX27-20-AQGR | 20 (40 μL) | 200 μL |
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| HSPB1-DDX27-20-AQAQ | 20 (40 μL) | 200 μL |
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HSPB1 Gene Summary
This gene encodes a member of the small heat shock protein (HSP20) family of proteins. In response to environmental stress, the encoded protein translocates from the cytoplasm to the nucleus and functions as a molecular chaperone that promotes the correct folding of other proteins. This protein plays an important role in the differentiation of a wide variety of cell types. Expression of this gene is correlated with poor clinical outcome in multiple human cancers, and the encoded protein may promote cancer cell proliferation and metastasis, while protecting cancer cells from apoptosis. Mutations in this gene have been identified in human patients with Charcot-Marie-Tooth disease and distal hereditary motor neuropathy. [provided by RefSeq, Aug 2017]
Gene Name: Heat Shock Protein Family B (small) Member 1
Chromosome: CHR7: 75931874 -75933614
Locus: 7q11.23
DDX27 Gene Summary
DEAD box proteins, characterized by the conserved motif Asp-Glu-Ala-Asp (DEAD), are putative RNA helicases. They are implicated in a number of cellular processes involving alteration of RNA secondary structure such as translation initiation, nuclear and mitochondrial splicing, and ribosome and spliceosome assembly. Based on their distribution patterns, some members of this family are believed to be involved in embryogenesis, spermatogenesis, and cellular growth and division. This gene encodes a DEAD box protein involved in the processing of 5.8S and 28S ribosomal RNAs. More specifically, the encoded protein localizes to the nucleolus, where it interacts with the PeBoW complex to ensure proper 3' end formation of 47S rRNA. [provided by RefSeq, Jan 2017]
Gene Name: DEAD-box Helicase 27
Chromosome: CHR20: 47835831 -47860614
Locus: 20q13.13
Gene Diseases
The HSPB1 DDX27 Fusion has been associated with the following diseases:
| Disease Name |
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| Cervical Squamous Cell Carcinoma And Endocervical Adenocarcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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