HSPB1-CLDN7 Fusion FISH Probe
The HSPB1-CLDN7 Fusion FISH Probe is used to confirm a fusion of the HSPB1 and CLDN7 genes. The fusion of the HSPB1 and CLDN7 genes has been associated with Cervical Squamous Cell Carcinoma And Endocervical Adenocarcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| HSPB1-CLDN7-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| HSPB1-CLDN7-20-RERE | 20 (40 μL) | 200 μL |
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| HSPB1-CLDN7-20-REOR | 20 (40 μL) | 200 μL |
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| HSPB1-CLDN7-20-REGO | 20 (40 μL) | 200 μL |
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| HSPB1-CLDN7-20-REGR | 20 (40 μL) | 200 μL |
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| HSPB1-CLDN7-20-REAQ | 20 (40 μL) | 200 μL |
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| HSPB1-CLDN7-20-ORRE | 20 (40 μL) | 200 μL |
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| HSPB1-CLDN7-20-OROR | 20 (40 μL) | 200 μL |
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| HSPB1-CLDN7-20-ORGO | 20 (40 μL) | 200 μL |
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| HSPB1-CLDN7-20-ORAQ | 20 (40 μL) | 200 μL |
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| HSPB1-CLDN7-20-GORE | 20 (40 μL) | 200 μL |
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| HSPB1-CLDN7-20-GOOR | 20 (40 μL) | 200 μL |
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| HSPB1-CLDN7-20-GOGO | 20 (40 μL) | 200 μL |
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| HSPB1-CLDN7-20-GOGR | 20 (40 μL) | 200 μL |
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| HSPB1-CLDN7-20-GOAQ | 20 (40 μL) | 200 μL |
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| HSPB1-CLDN7-20-GRRE | 20 (40 μL) | 200 μL |
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| HSPB1-CLDN7-20-GROR | 20 (40 μL) | 200 μL |
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| HSPB1-CLDN7-20-GRGO | 20 (40 μL) | 200 μL |
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| HSPB1-CLDN7-20-GRGR | 20 (40 μL) | 200 μL |
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| HSPB1-CLDN7-20-GRAQ | 20 (40 μL) | 200 μL |
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| HSPB1-CLDN7-20-AQRE | 20 (40 μL) | 200 μL |
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| HSPB1-CLDN7-20-AQOR | 20 (40 μL) | 200 μL |
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| HSPB1-CLDN7-20-AQGO | 20 (40 μL) | 200 μL |
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| HSPB1-CLDN7-20-AQGR | 20 (40 μL) | 200 μL |
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| HSPB1-CLDN7-20-AQAQ | 20 (40 μL) | 200 μL |
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CLDN7 Gene Summary
This gene encodes a member of the claudin family. Claudins are integral membrane proteins and components of tight junction strands. Tight junction strands serve as a physical barrier to prevent solutes and water from passing freely through the paracellular space between epithelial or endothelial cell sheets, and also play critical roles in maintaining cell polarity and signal transductions. Differential expression of this gene has been observed in different types of malignancies, including breast cancer, ovarian cancer, hepatocellular carcinomas, urinary tumors, prostate cancer, lung cancer, head and neck cancers, thyroid carcinomas, etc.. Alternatively spliced transcript variants encoding different isoforms have been found.[provided by RefSeq, May 2010]
Gene Name: Claudin 7
Chromosome: CHR17: 7163221 -7166512
Locus: 17p13.1
HSPB1 Gene Summary
This gene encodes a member of the small heat shock protein (HSP20) family of proteins. In response to environmental stress, the encoded protein translocates from the cytoplasm to the nucleus and functions as a molecular chaperone that promotes the correct folding of other proteins. This protein plays an important role in the differentiation of a wide variety of cell types. Expression of this gene is correlated with poor clinical outcome in multiple human cancers, and the encoded protein may promote cancer cell proliferation and metastasis, while protecting cancer cells from apoptosis. Mutations in this gene have been identified in human patients with Charcot-Marie-Tooth disease and distal hereditary motor neuropathy. [provided by RefSeq, Aug 2017]
Gene Name: Heat Shock Protein Family B (small) Member 1
Chromosome: CHR7: 75931874 -75933614
Locus: 7q11.23
Gene Diseases
The HSPB1 CLDN7 Fusion has been associated with the following diseases:
| Disease Name |
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| Cervical Squamous Cell Carcinoma And Endocervical Adenocarcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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