HSP90B1-UTRN Fusion FISH Probe
The HSP90B1-UTRN Fusion FISH Probe is used to confirm a fusion of the HSP90B1 and UTRN genes. The fusion of the HSP90B1 and UTRN genes has been associated with Head And Neck Squamous Cell Carcinoma . These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| HSP90B1-UTRN-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| HSP90B1-UTRN-20-RERE | 20 (40 μL) | 200 μL |
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| HSP90B1-UTRN-20-REOR | 20 (40 μL) | 200 μL |
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| HSP90B1-UTRN-20-REGO | 20 (40 μL) | 200 μL |
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| HSP90B1-UTRN-20-REGR | 20 (40 μL) | 200 μL |
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| HSP90B1-UTRN-20-REAQ | 20 (40 μL) | 200 μL |
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| HSP90B1-UTRN-20-ORRE | 20 (40 μL) | 200 μL |
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| HSP90B1-UTRN-20-OROR | 20 (40 μL) | 200 μL |
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| HSP90B1-UTRN-20-ORGO | 20 (40 μL) | 200 μL |
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| HSP90B1-UTRN-20-ORAQ | 20 (40 μL) | 200 μL |
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| HSP90B1-UTRN-20-GORE | 20 (40 μL) | 200 μL |
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| HSP90B1-UTRN-20-GOOR | 20 (40 μL) | 200 μL |
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| HSP90B1-UTRN-20-GOGO | 20 (40 μL) | 200 μL |
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| HSP90B1-UTRN-20-GOGR | 20 (40 μL) | 200 μL |
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| HSP90B1-UTRN-20-GOAQ | 20 (40 μL) | 200 μL |
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| HSP90B1-UTRN-20-GRRE | 20 (40 μL) | 200 μL |
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| HSP90B1-UTRN-20-GROR | 20 (40 μL) | 200 μL |
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| HSP90B1-UTRN-20-GRGO | 20 (40 μL) | 200 μL |
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| HSP90B1-UTRN-20-GRGR | 20 (40 μL) | 200 μL |
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| HSP90B1-UTRN-20-GRAQ | 20 (40 μL) | 200 μL |
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| HSP90B1-UTRN-20-AQRE | 20 (40 μL) | 200 μL |
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| HSP90B1-UTRN-20-AQOR | 20 (40 μL) | 200 μL |
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| HSP90B1-UTRN-20-AQGO | 20 (40 μL) | 200 μL |
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| HSP90B1-UTRN-20-AQGR | 20 (40 μL) | 200 μL |
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| HSP90B1-UTRN-20-AQAQ | 20 (40 μL) | 200 μL |
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HSP90B1 Gene Summary
This gene encodes a member of a family of adenosine triphosphate(ATP)-metabolizing molecular chaperones with roles in stabilizing and folding other proteins. The encoded protein is localized to melanosomes and the endoplasmic reticulum. Expression of this protein is associated with a variety of pathogenic states, including tumor formation. There is a microRNA gene located within the 5' exon of this gene. There are pseudogenes for this gene on chromosomes 1 and 15. [provided by RefSeq, Aug 2012]
Gene Name: Heat Shock Protein 90 Beta Family Member 1
Chromosome: CHR12: 104324188 -104341703
Locus: 12q23.3
UTRN Gene Summary
This gene shares both structural and functional similarities with the dystrophin gene. It contains an actin-binding N-terminus, a triple coiled-coil repeat central region, and a C-terminus that consists of protein-protein interaction motifs which interact with dystroglycan protein components. The protein encoded by this gene is located at the neuromuscular synapse and myotendinous junctions, where it participates in post-synaptic membrane maintenance and acetylcholine receptor clustering. Mouse studies suggest that this gene may serve as a functional substitute for the dystrophin gene and therefore, may serve as a potential therapeutic alternative to muscular dystrophy which is caused by mutations in the dystrophin gene. Alternative splicing of the utrophin gene has been described; however, the full-length nature of these variants has not yet been determined. [provided by RefSeq, Jul 2008]
Gene Name: Utrophin
Chromosome: CHR6: 144612872 -145174170
Locus: 6q24.2
Gene Diseases
The HSP90B1 UTRN Fusion has been associated with the following diseases:
| Disease Name |
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| Head And Neck Squamous Cell Carcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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