HSD17B14-PLEKHA4 Fusion FISH Probe
The HSD17B14-PLEKHA4 Fusion FISH Probe is used to confirm a fusion of the HSD17B14 and PLEKHA4 genes. The fusion of the HSD17B14 and PLEKHA4 genes has been associated with Adrenocortical Carcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| HSD17B14-PLEKHA4-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| HSD17B14-PLEKHA4-20-RERE | 20 (40 μL) | 200 μL |
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| HSD17B14-PLEKHA4-20-REOR | 20 (40 μL) | 200 μL |
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| HSD17B14-PLEKHA4-20-REGO | 20 (40 μL) | 200 μL |
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| HSD17B14-PLEKHA4-20-REGR | 20 (40 μL) | 200 μL |
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| HSD17B14-PLEKHA4-20-REAQ | 20 (40 μL) | 200 μL |
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| HSD17B14-PLEKHA4-20-ORRE | 20 (40 μL) | 200 μL |
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| HSD17B14-PLEKHA4-20-OROR | 20 (40 μL) | 200 μL |
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| HSD17B14-PLEKHA4-20-ORGO | 20 (40 μL) | 200 μL |
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| HSD17B14-PLEKHA4-20-ORAQ | 20 (40 μL) | 200 μL |
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| HSD17B14-PLEKHA4-20-GORE | 20 (40 μL) | 200 μL |
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| HSD17B14-PLEKHA4-20-GOOR | 20 (40 μL) | 200 μL |
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| HSD17B14-PLEKHA4-20-GOGO | 20 (40 μL) | 200 μL |
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| HSD17B14-PLEKHA4-20-GOGR | 20 (40 μL) | 200 μL |
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| HSD17B14-PLEKHA4-20-GOAQ | 20 (40 μL) | 200 μL |
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| HSD17B14-PLEKHA4-20-GRRE | 20 (40 μL) | 200 μL |
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| HSD17B14-PLEKHA4-20-GROR | 20 (40 μL) | 200 μL |
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| HSD17B14-PLEKHA4-20-GRGO | 20 (40 μL) | 200 μL |
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| HSD17B14-PLEKHA4-20-GRGR | 20 (40 μL) | 200 μL |
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| HSD17B14-PLEKHA4-20-GRAQ | 20 (40 μL) | 200 μL |
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| HSD17B14-PLEKHA4-20-AQRE | 20 (40 μL) | 200 μL |
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| HSD17B14-PLEKHA4-20-AQOR | 20 (40 μL) | 200 μL |
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| HSD17B14-PLEKHA4-20-AQGO | 20 (40 μL) | 200 μL |
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| HSD17B14-PLEKHA4-20-AQGR | 20 (40 μL) | 200 μL |
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| HSD17B14-PLEKHA4-20-AQAQ | 20 (40 μL) | 200 μL |
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HSD17B14 Gene Summary
17-beta-hydroxysteroid dehydrogenases, such as HSD17B14, are primarily involved in metabolism of steroids at the C17 position and also of other substrates, such as fatty acids, prostaglandins, and xenobiotics (Lukacik et al., 2007 [PubMed 17067289]).[supplied by OMIM, Jun 2009]
Gene Name: Hydroxysteroid 17-beta Dehydrogenase 14
Chromosome: CHR19: 49316273 -49339934
Locus: 19q13.33
PLEKHA4 Gene Summary
This gene encodes a pleckstrin homology (PH) domain-containing protein. The PH domain is found near the N-terminus and contains a putative phosphatidylinositol 3, 4, 5-triphosphate-binding motif (PPBM). Elevated expression of this gene has been observed in some melanomas. Alternate splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, May 2017]
Gene Name: Pleckstrin Homology Domain Containing A4
Chromosome: CHR19: 49340353 -49371884
Locus: 19q13.33
Gene Diseases
The HSD17B14 PLEKHA4 Fusion has been associated with the following diseases:
| Disease Name |
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| Adrenocortical Carcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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