HSD17B12-WT1 Fusion FISH Probe
The HSD17B12-WT1 Fusion FISH Probe is used to confirm a fusion of the HSD17B12 and WT1 genes. The fusion of the HSD17B12 and WT1 genes has been associated with Kidney Chromophobe. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
|---|---|---|---|---|
| HSD17B12-WT1-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
|
|
| HSD17B12-WT1-20-RERE | 20 (40 μL) | 200 μL |
|
|
| HSD17B12-WT1-20-REOR | 20 (40 μL) | 200 μL |
|
|
| HSD17B12-WT1-20-REGO | 20 (40 μL) | 200 μL |
|
|
| HSD17B12-WT1-20-REGR | 20 (40 μL) | 200 μL |
|
|
| HSD17B12-WT1-20-REAQ | 20 (40 μL) | 200 μL |
|
|
| HSD17B12-WT1-20-ORRE | 20 (40 μL) | 200 μL |
|
|
| HSD17B12-WT1-20-OROR | 20 (40 μL) | 200 μL |
|
|
| HSD17B12-WT1-20-ORGO | 20 (40 μL) | 200 μL |
|
|
| HSD17B12-WT1-20-ORAQ | 20 (40 μL) | 200 μL |
|
|
| HSD17B12-WT1-20-GORE | 20 (40 μL) | 200 μL |
|
|
| HSD17B12-WT1-20-GOOR | 20 (40 μL) | 200 μL |
|
|
| HSD17B12-WT1-20-GOGO | 20 (40 μL) | 200 μL |
|
|
| HSD17B12-WT1-20-GOGR | 20 (40 μL) | 200 μL |
|
|
| HSD17B12-WT1-20-GOAQ | 20 (40 μL) | 200 μL |
|
|
| HSD17B12-WT1-20-GRRE | 20 (40 μL) | 200 μL |
|
|
| HSD17B12-WT1-20-GROR | 20 (40 μL) | 200 μL |
|
|
| HSD17B12-WT1-20-GRGO | 20 (40 μL) | 200 μL |
|
|
| HSD17B12-WT1-20-GRGR | 20 (40 μL) | 200 μL |
|
|
| HSD17B12-WT1-20-GRAQ | 20 (40 μL) | 200 μL |
|
|
| HSD17B12-WT1-20-AQRE | 20 (40 μL) | 200 μL |
|
|
| HSD17B12-WT1-20-AQOR | 20 (40 μL) | 200 μL |
|
|
| HSD17B12-WT1-20-AQGO | 20 (40 μL) | 200 μL |
|
|
| HSD17B12-WT1-20-AQGR | 20 (40 μL) | 200 μL |
|
|
| HSD17B12-WT1-20-AQAQ | 20 (40 μL) | 200 μL |
|
WT1 Gene Summary
This gene encodes a transcription factor that contains four zinc-finger motifs at the C-terminus and a proline/glutamine-rich DNA-binding domain at the N-terminus. It has an essential role in the normal development of the urogenital system, and it is mutated in a small subset of patients with Wilms tumor. This gene exhibits complex tissue-specific and polymorphic imprinting pattern, with biallelic, and monoallelic expression from the maternal and paternal alleles in different tissues. Multiple transcript variants have been described. In several variants, there is evidence for the use of a non-AUG (CUG) translation initiation codon upstream of, and in-frame with the first AUG. Authors of PMID:7926762 also provide evidence that WT1 mRNA undergoes RNA editing in human and rat, and that this process is tissue-restricted and developmentally regulated. [provided by RefSeq, Mar 2015]
Gene Name: Wilms Tumor 1
Chromosome: CHR11: 32409321 -32457081
Locus: 11p13
HSD17B12 Gene Summary
This gene encodes a very important 17beta-hydroxysteroid dehydrogenase (17beta-HSD) that converts estrone into estradiol in ovarian tissue. This enzyme is also involved in fatty acid elongation. [provided by RefSeq, Oct 2011]
Gene Name: Hydroxysteroid 17-beta Dehydrogenase 12
Chromosome: CHR11: 43702142 -43878169
Locus: 11p11.2
Gene Diseases
The HSD17B12 WT1 Fusion has been associated with the following diseases:
| Disease Name |
|---|
| Kidney Chromophobe |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
|---|